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B5FEP5 (PUR7_VIBFM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:VFMJ11_1591
OrganismVibrio fischeri (strain MJ11) [Complete proteome] [HAMAP]
Taxonomic identifier388396 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117861

Sequences

Sequence LengthMass (Da)Tools
B5FEP5 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 9C68F0A417CBC8D3

FASTA36741,576
        10         20         30         40         50         60 
MSLSDQVLAV NDDLPIRTDK PVHSGKVRSV YWLTEEDSRR LIKEKGYNVA PDAPLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCI WRGEGDLKGI PGKGAALNAI SNHWFQLFKD NGLADSHILD IPHPFVWIVQ 

       130        140        150        160        170        180 
KAKPVMIEAI CRQYITGSMW RAYTQGEREF CGITLPERLE KDEQLAELLL TPSTKGILKG 

       190        200        210        220        230        240 
IDGVPEVDDV NITRKNIEDN YDKFNFSCVE DIATYEKLLK EGFAVIAKAL TKIDQIFVDT 

       250        260        270        280        290        300 
KFEFGYVEDA QGNEKLIYMD EVGTPDSSRI WDTKAYRSGH IIENSKEGFR QFLLNHFPDP 

       310        320        330        340        350        360 
DILLNKNRME ERFALAKENA LPLEAMMDLS KTYLDIAAKI TGAPITLSDN PKAEIIKVLK 


EEYQLVD

« Hide

References

[1]"Complete sequence of Vibrio fischeri strain MJ11."
Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MJ11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001139 Genomic DNA. Translation: ACH66258.1.
RefSeqYP_002156310.1. NC_011184.1.

3D structure databases

ProteinModelPortalB5FEP5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5FEP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6805659.
GenomeReviewsGene locus VFMJ11_1591 in contig CP001139_GR.
KEGGvfm:VFMJ11_1591.
PATRIC20121642. VBIVibFis37164_1536.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG555040.
OMASSRIWDG.
ProtClustDBPRK13960.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. False negative.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_VIBFM
AccessionPrimary (citable) accession number: B5FEP5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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