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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:VFMJ11_2567
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001857 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001231001 – 807Glycerol-3-phosphate acyltransferaseAdd BLAST807

Structurei

3D structure databases

ProteinModelPortaliB5FCB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 310HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FCB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGHTIYHS LLKLPLSVMV KSSSIPSNPI EDLNIDLERP IIYALPFRSH
60 70 80 90 100
VDLLTLQKSA LELGLPDPLS PIEIEGVKYP RYVFTSIGPK MFDTDDDLPQ
110 120 130 140 150
ESLDLFKIVL KHHADNPDAD FQLIPTSILW GRKPGKEGTS KPHLMPLNGP
160 170 180 190 200
QKFVTLIKAG RDSTVRISPV VSLRYMADNH GSDEAIAHKL ARVAKIHFSR
210 220 230 240 250
QKLAASGPNL PNRQALFNRL LKSQAIEKVI LEEAKSRNVD VEKVRKEAMG
260 270 280 290 300
IMEEIATNFS YSLIKNGNRI LKWLWNRLYQ GLNINNASTV RKLAQEGHEI
310 320 330 340 350
VYVPCHRSHM DYLLLSYVLY HEGLVPPHIA AGINLNFFPA GPIFRRGGAF
360 370 380 390 400
FIRRSFKGNR LYSTIFREYL AELFAKGYSV EYFSEGGRSR TGRLLQAKTG
410 420 430 440 450
MLAMTVQAML RGLNRPVTLV PVYIGYEHVM EVTTYAKELR GKRKEKENAG
460 470 480 490 500
QVLRTLRKLR NFGQGYVNFG EPISLNHYLN EHAPNWSESI NPIEPQKPEW
510 520 530 540 550
MTPVVNGIAN KMMTHINDAA AANALTLCAT ALLAANQRAL SKEDLTEQLD
560 570 580 590 600
CYLQILRNVP YSATATVPSE DADALLEHAI KLDKFVIEKD TLGEIVSLDR
610 620 630 640 650
NQSLLMTYYR NNIIHLFALP SLIAKLVVHH DTITVEQIQE QIKLIYPFLK
660 670 680 690 700
AELFLHYEED ELASIVNNHI DELVQQNLIL RDGDTLQLCN ANIRKLHLLA
710 720 730 740 750
HTISETLQRY AIALTHLQAS PDLGKDELEE QSQIMAQRLS RLHGINAPEF
760 770 780 790 800
FDKGVFCILF NTLKTEGYLD EDGAAVLSKV EPLSQDIAHL LTPEIKLTIH

AVMTKED
Length:807
Mass (Da):91,095
Last modified:October 14, 2008 - v1
Checksum:i8F6E51DF7E870E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67388.1.
RefSeqiWP_012534392.1. NC_011184.1.

Genome annotation databases

EnsemblBacteriaiACH67388; ACH67388; VFMJ11_2567.
KEGGivfm:VFMJ11_2567.
PATRICi20123614. VBIVibFis37164_2458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67388.1.
RefSeqiWP_012534392.1. NC_011184.1.

3D structure databases

ProteinModelPortaliB5FCB3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH67388; ACH67388; VFMJ11_2567.
KEGGivfm:VFMJ11_2567.
PATRICi20123614. VBIVibFis37164_2458.

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_VIBFM
AccessioniPrimary (citable) accession number: B5FCB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.