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B5FC70

- PUR9_VIBFM

UniProt

B5FC70 - PUR9_VIBFM

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:VFMJ11_2512
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Bifunctional purine biosynthesis protein PurHPRO_1000096106Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388396.VFMJ11_2512.

Structurei

3D structure databases

ProteinModelPortaliB5FC70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FC70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNARPIRRA LISVSDKTGI VEFAQALAER GVDILSTGGT ARLLAEKGIS
60 70 80 90 100
VTEVSDYTGF PEMMDGRVKT LHPKVHGGVL GRRGQDDGIM EQHGINPIDM
110 120 130 140 150
VVVNLYPFAE TVAKEGCTLA DAVENIDIGG PTMVRSAAKN HKDVTIVVNA
160 170 180 190 200
HDYDRVITEM DANEKSLTLE TRFDLAIAAF EHTASYDGMI ANYFGTMVPS
210 220 230 240 250
YGENKEGDEE SKFPRTFNQQ FEKKQDMRYG ENSHQAAAFY VEANPEEASV
260 270 280 290 300
STARQIQGKA LSYNNIADTD AALECVKEFD EPACVIVKHA NPCGVALGKN
310 320 330 340 350
ILEAYDRAFK TDPTSAFGGI IAFNRELDAA TATAITERQF VEVIIAPSVS
360 370 380 390 400
AEAVEIVAAK KNLRLLECGE WTTKTTGFDV KRVNGGLLVQ DRDQGMVSED
410 420 430 440 450
DLQVVSKRQP TAEELKDALF CWKVAKYVKS NAIVYSKGDM TIGVGAGQMS
460 470 480 490 500
RVYSAKIAGI KAADEGLQVE GCVMASDAFF PFRDGIDAAA EAGIKCVIQP
510 520 530
GGSMRDNEVI EAADEHGMAM IFTGMRHFRH
Length:530
Mass (Da):57,566
Last modified:October 14, 2008 - v1
Checksum:iDDAD705121FB0687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67096.1.
RefSeqiWP_012534194.1. NC_011184.1.
YP_002157186.1. NC_011184.1.

Genome annotation databases

EnsemblBacteriaiACH67096; ACH67096; VFMJ11_2512.
GeneIDi6806710.
KEGGivfm:VFMJ11_2512.
PATRICi20123498. VBIVibFis37164_2415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67096.1 .
RefSeqi WP_012534194.1. NC_011184.1.
YP_002157186.1. NC_011184.1.

3D structure databases

ProteinModelPortali B5FC70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388396.VFMJ11_2512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH67096 ; ACH67096 ; VFMJ11_2512 .
GeneIDi 6806710.
KEGGi vfm:VFMJ11_2512.
PATRICi 20123498. VBIVibFis37164_2415.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11.

Entry informationi

Entry nameiPUR9_VIBFM
AccessioniPrimary (citable) accession number: B5FC70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3