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B5FBW7

- ISPE_VIBFM

UniProt

B5FBW7 - ISPE_VIBFM

Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ispE

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotation

    Catalytic activityi

    ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131UniRule annotation
    Active sitei138 – 1381UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi96 – 10611ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00056; UER00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
    Short name:
    CMKUniRule annotation
    Alternative name(s):
    4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
    Gene namesi
    Name:ispEUniRule annotation
    Ordered Locus Names:VFMJ11_0801
    OrganismiVibrio fischeri (strain MJ11)
    Taxonomic identifieri388396 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000001857: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2882884-diphosphocytidyl-2-C-methyl-D-erythritol kinasePRO_1000092124Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi388396.VFMJ11_0801.

    Structurei

    3D structure databases

    ProteinModelPortaliB5FBW7.
    SMRiB5FBW7. Positions 5-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1947.
    HOGENOMiHOG000019601.
    KOiK00919.
    OMAiVSTAEIF.
    OrthoDBiEOG62VNQ2.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00061. IspE.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010376. IspE. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00154. ispE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5FBW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITKTTRWPS PAKLNLFLYI NGQQENGYHE LQTLFQFIDL CDHLTITSNQ    50
    SGQITLAPDI PGVKTEDNLI WKAATLLQQH SQCEFGAHIE IEKILPMGGG 100
    IGGGSSNAAT VLIALNFLWQ LNLSNDTLAA LGVKLGADVP IFVHGFAAFA 150
    EGIGEKLQPA TPKELWYVLI KPEVSIATVD VFTHPDLVRN TPKQPLNALL 200
    EATYVNDCEK IVRSVYPEVD YQLSWLLEYA PSRLTGTGAC VFAEFNSEKE 250
    AQDVYSLIPD NATGFIARGM NTSPLNRTLE EYKSLCKI 288
    Length:288
    Mass (Da):31,741
    Last modified:October 14, 2008 - v1
    Checksum:iF36B0295FC6A3FBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001139 Genomic DNA. Translation: ACH66983.1.
    RefSeqiWP_012534115.1. NC_011184.1.
    YP_002155526.1. NC_011184.1.

    Genome annotation databases

    EnsemblBacteriaiACH66983; ACH66983; VFMJ11_0801.
    GeneIDi6806429.
    KEGGivfm:VFMJ11_0801.
    PATRICi20120065. VBIVibFis37164_0754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001139 Genomic DNA. Translation: ACH66983.1 .
    RefSeqi WP_012534115.1. NC_011184.1.
    YP_002155526.1. NC_011184.1.

    3D structure databases

    ProteinModelPortali B5FBW7.
    SMRi B5FBW7. Positions 5-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 388396.VFMJ11_0801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH66983 ; ACH66983 ; VFMJ11_0801 .
    GeneIDi 6806429.
    KEGGi vfm:VFMJ11_0801.
    PATRICi 20120065. VBIVibFis37164_0754.

    Phylogenomic databases

    eggNOGi COG1947.
    HOGENOMi HOG000019601.
    KOi K00919.
    OMAi VSTAEIF.
    OrthoDBi EOG62VNQ2.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00094 .

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00061. IspE.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010376. IspE. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00154. ispE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Vibrio fischeri strain MJ11."
      Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MJ11.

    Entry informationi

    Entry nameiISPE_VIBFM
    AccessioniPrimary (citable) accession number: B5FBW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3