B5FBP7 (ARGE_VIBFM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine deacetylase
Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16

Alternative name(s):
N-acetylornithinase
Short name=NAO

Gene names

Name:	argE
Ordered Locus Names:	VFMJ11_2419

Organism

Vibrio fischeri (strain MJ11) [Complete proteome] [HAMAP]

Taxonomic identifier

388396 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio › Vibrio fischeri

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP-Rule MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. Glutathione By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP-Rule MF_01108
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: HAMAP cobalt ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Acetylornithine deacetylase HAMAP-Rule MF_01108		PRO_1000137082
Sites
	Active site	78	1	By similarity
	Active site	140	1	By similarity
	Metal binding	76	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 2 By similarity
	Metal binding	141	1	Cobalt or zinc 2 By similarity
	Metal binding	165	1	Cobalt or zinc 1 By similarity
	Metal binding	351	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5FBP7 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 79C4168AB0C86926	FASTA	378	41,812
	10 20 30 40 50 60 MKFPEFKDYY QQLISTSSIS STDSSWDEGN AEVINKLAQW CEDLGCEVEI EEIEKGKLNL 70 80 90 100 110 120 LAKLGSGEGG LLLAGHTDTV PYDEGRWNYE PHALTEANDR FYGLGTADMK GFFAFILEAI 130 140 150 160 170 180 KNINWKDQSK PLYILATCDE ETTMLGARHF ASNTKIQPDY CIIGEPTSLK PIRGHKGHVA 190 200 210 220 230 240 NAIRVTGKSG HSSDPAHGVN ALEIMNEIMF ALMTLKNKLV KEYHNPGFSI PYPTLNLGHI 250 260 270 280 290 300 HGGDSPNRIC GCCELHYDVR PLPGISLDGL DNMLRDALKE VEAKWPGRID ITPLHEPIPG 310 320 330 340 350 360 YECSADSPIV TSTADICGQD VETVNYCTEA PFLQDLCPTL VLGPGSIEQA HQPDEYLAFS 370 FIDPTISVLS KLMYKHCF

References

[1]

"Complete sequence of Vibrio fischeri strain MJ11." Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MJ11.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001139 Genomic DNA. Translation: ACH66706.1.
RefSeq	YP_002157102.1. NC_011184.1.
3D structure databases
ProteinModelPortal	B5FBP7.
ModBase	Search...
Protein-protein interaction databases
STRING	388396.VFMJ11_2419.
Protein family/group databases
MEROPS	M20.974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACH66706; ACH66706; VFMJ11_2419.
GeneID	6806714.
KEGG	vfm:VFMJ11_2419.
PATRIC	20123312. VBIVibFis37164_2331.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0624.
HOGENOM	HOG000243769.
KO	K01438.
OMA	CAHQPGE.
ProtClustDB	PRK05111.
Enzyme and pathway databases
UniPathway	UPA00068; UER00110.
Family and domain databases
HAMAP	MF_01108. ArgE.
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_VIBFM

Accession

Primary (citable) accession number: B5FBP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program