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B5FAZ8 (B5FAZ8_VIBFM) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419

Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419 EMBL ACH65476.1
Ordered Locus Names:VFMJ11_0669 EMBL ACH65476.1
OrganismVibrio fischeri (strain MJ11) [Complete proteome] [HAMAP] EMBL ACH65476.1
Taxonomic identifier388396 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length1303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419 SAAS SAAS022940

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419 SAAS SAAS022940

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00419 SAAS SAAS022940

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419 SAAS SAAS022940.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419

Contains glutamine amidotransferase type-1 domain. SAAS SAAS022940

Contains glutamine amidotransferase type-domain. SAAS SAAS022940

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding308 – 31912ATP By similarity HAMAP-Rule MF_00419

Sites

Active site11431Nucleophile By similarity HAMAP-Rule MF_00419
Active site12681 By similarity HAMAP-Rule MF_00419
Active site12701 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
B5FAZ8 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 184AEDF17D7D9344

FASTA1,303142,216
        10         20         30         40         50         60 
MRILRGSPAL SEFRVNKLLE LCRELSLPVT GIYAEFAHFA DVTAELDASE VQKLEKLLTY 

        70         80         90        100        110        120 
GPTIEEHEPE GLLLLTTPRP GTISPWSSKS TDIAHNCGLD KIARLERGTA FYIESSEELS 

       130        140        150        160        170        180 
ELQLVELKAI LHDRMMEVVF TDFESASALF AVSEPAPYTE VDLLTGGRKA LEDANVTLGL 

       190        200        210        220        230        240 
ALAEDEIDYL LESFTEKLER NPTDIELMMF AQANSEHCRH KIFNADWTID GVKQEKSLFK 

       250        260        270        280        290        300 
MIKNTFEVTP DNVLSAYKDN AAVMTGSTVG RFFPDPKTRQ YNYHQEKTHI LMKVETHNHP 

       310        320        330        340        350        360 
TAISPWPGAS TGSGGEIRDE GATGIGGKPK AGLVAFSVSN LKIPNFVQPW ETDFGKPSRI 

       370        380        390        400        410        420 
VTALDIMLEG PLGGAAFNNE FGRPNLLGYF RTYEEKVNSH AGEEVRGYHK PIMLAGGLGN 

       430        440        450        460        470        480 
IRDEHVQKKE IPVGASLIVL GGPAMNIGLG GGAASSMDSG SSSEDLDFAS VQRENPEMER 

       490        500        510        520        530        540 
RCQEVIDRCW QLGDANPIAF IHDVGAGGIS NALPELVDDG ERGGIFNLRD VPNDEPGMSP 

       550        560        570        580        590        600 
LEIWCNESQE RYVMAVADKD MATFDAICKR ERAPYAVVGK ATEERELKLE DSHFDNTPID 

       610        620        630        640        650        660 
MPMDILLGKT PKMHRDATTL KVNNPAIDRS GIEMNEAVNR VLRLPTVAEK TFLITIGDRS 

       670        680        690        700        710        720 
VTGLVARDQM VGPWQVPVAN CAVTAASYDS YHGEAMSLGE RTPVALLDFG ASARLAVGEA 

       730        740        750        760        770        780 
ITNIAATNIG DIKHIKLSAN WMSPAGHPGE DAGLYEAVKA VGEELCPALG LTIPVGKDSM 

       790        800        810        820        830        840 
SMKTKWEENG EQKEVTSPLS LVITAFARVE DVRKTITPQL RTPDNLEGLG NTSLVLIDLG 

       850        860        870        880        890        900 
NGKNRLGATA LAQVYKQLGD KPADVDNAAQ LKGFYEGVQA LVANDQVVAY HDKGDGGLFV 

       910        920        930        940        950        960 
TLAEMAFAGH CGVNANIEAL GEDTLAALFN EELGAVIQVR NDDLDAVLST LAANGLEACS 

       970        980        990       1000       1010       1020 
HVIGSVETSD ELVIRSGEFV VIERNRTELR TIWAETTHKM QGLRDNPVCA DQEHEAKKDN 

      1030       1040       1050       1060       1070       1080 
SDPGLNVKLS FDVNEDIAAS FINTGAKPKM AILREQGVNS HVEMAAAFDR AGFEATDIHM 

      1090       1100       1110       1120       1130       1140 
SDILTGQAVL EEYNGLVACG GFSYGDVLGA GEGWAKSVLF NDATRDQFEN FFKREDTFSL 

      1150       1160       1170       1180       1190       1200 
GVCNGCQMLS NLRELIPGAE YWPRFVRNES ERFEARFSLV EVQKSDSVFF NGMEGSRMPI 

      1210       1220       1230       1240       1250       1260 
AVSHGEGRVE VRDNEHLNAI ENSGTVALRY VDNHGNPTQQ YPNNPNGSPN AITGLTTTDG 

      1270       1280       1290       1300 
RVTIMMPHPE RVFRTVANSW SPEGWGENGA WMRMFQNARK NIG 

« Hide

References

[1]"Complete sequence of Vibrio fischeri strain MJ11."
Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MJ11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001139 Genomic DNA. Translation: ACH65476.1.
RefSeqYP_002155412.1. NC_011184.1.

3D structure databases

ProteinModelPortalB5FAZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING388396.VFMJ11_0669.

Protein family/group databases

MEROPSC56.972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH65476; ACH65476; VFMJ11_0669.
GeneID6806582.
KEGGvfm:VFMJ11_0669.
PATRIC20119801. VBIVibFis37164_0640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMAWPHFVRN.
OrthoDBEOG6FNHHR.
ProtClustDBPRK05297.

Enzyme and pathway databases

UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5FAZ8_VIBFM
AccessionPrimary (citable) accession number: B5FAZ8
Entry history
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)