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B5FAZ8

- B5FAZ8_VIBFM

UniProt

B5FAZ8 - B5FAZ8_VIBFM

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Protein
Phosphoribosylformylglycinamidine synthase
Gene
purL, VFMJ11_0669
Organism
Vibrio fischeri (strain MJ11)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate By similarity.UniRule annotation

Catalytic activityi

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei679 – 6791ATP; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi719 – 7191Magnesium By similarityUniRule annotation
Metal bindingi723 – 7231Magnesium By similarityUniRule annotation
Metal bindingi892 – 8921Magnesium By similarityUniRule annotation
Active sitei1143 – 11431Nucleophile By similarityUniRule annotation
Active sitei1268 – 12681 By similarityUniRule annotation
Active sitei1270 – 12701 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi308 – 31912ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. phosphoribosylformylglycinamidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00128.

Protein family/group databases

MEROPSiC56.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthaseUniRule annotation (EC:6.3.5.3UniRule annotation)
Short name:
FGAM synthaseUniRule annotation
Short name:
FGAMSUniRule annotation
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Gene namesi
Name:purLUniRule annotationImported
Ordered Locus Names:VFMJ11_0669Imported
OrganismiVibrio fischeri (strain MJ11)Imported
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi388396.VFMJ11_0669.

Structurei

3D structure databases

ProteinModelPortaliB5FAZ8.

Family & Domainsi

Sequence similaritiesi

Contains glutamine amidotransferase type-1 domain.SAAS annotations
Contains glutamine amidotransferase type-domain.SAAS annotations
In the N-terminal section; belongs to the FGAMS family.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0046.
HOGENOMiHOG000261359.
KOiK01952.
OMAiGEGHAEF.
OrthoDBiEOG6FNHHR.

Family and domain databases

Gene3Di3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00419. PurL_1.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsiTIGR01735. FGAM_synt. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5FAZ8-1 [UniParc]FASTAAdd to Basket

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MRILRGSPAL SEFRVNKLLE LCRELSLPVT GIYAEFAHFA DVTAELDASE     50
VQKLEKLLTY GPTIEEHEPE GLLLLTTPRP GTISPWSSKS TDIAHNCGLD 100
KIARLERGTA FYIESSEELS ELQLVELKAI LHDRMMEVVF TDFESASALF 150
AVSEPAPYTE VDLLTGGRKA LEDANVTLGL ALAEDEIDYL LESFTEKLER 200
NPTDIELMMF AQANSEHCRH KIFNADWTID GVKQEKSLFK MIKNTFEVTP 250
DNVLSAYKDN AAVMTGSTVG RFFPDPKTRQ YNYHQEKTHI LMKVETHNHP 300
TAISPWPGAS TGSGGEIRDE GATGIGGKPK AGLVAFSVSN LKIPNFVQPW 350
ETDFGKPSRI VTALDIMLEG PLGGAAFNNE FGRPNLLGYF RTYEEKVNSH 400
AGEEVRGYHK PIMLAGGLGN IRDEHVQKKE IPVGASLIVL GGPAMNIGLG 450
GGAASSMDSG SSSEDLDFAS VQRENPEMER RCQEVIDRCW QLGDANPIAF 500
IHDVGAGGIS NALPELVDDG ERGGIFNLRD VPNDEPGMSP LEIWCNESQE 550
RYVMAVADKD MATFDAICKR ERAPYAVVGK ATEERELKLE DSHFDNTPID 600
MPMDILLGKT PKMHRDATTL KVNNPAIDRS GIEMNEAVNR VLRLPTVAEK 650
TFLITIGDRS VTGLVARDQM VGPWQVPVAN CAVTAASYDS YHGEAMSLGE 700
RTPVALLDFG ASARLAVGEA ITNIAATNIG DIKHIKLSAN WMSPAGHPGE 750
DAGLYEAVKA VGEELCPALG LTIPVGKDSM SMKTKWEENG EQKEVTSPLS 800
LVITAFARVE DVRKTITPQL RTPDNLEGLG NTSLVLIDLG NGKNRLGATA 850
LAQVYKQLGD KPADVDNAAQ LKGFYEGVQA LVANDQVVAY HDKGDGGLFV 900
TLAEMAFAGH CGVNANIEAL GEDTLAALFN EELGAVIQVR NDDLDAVLST 950
LAANGLEACS HVIGSVETSD ELVIRSGEFV VIERNRTELR TIWAETTHKM 1000
QGLRDNPVCA DQEHEAKKDN SDPGLNVKLS FDVNEDIAAS FINTGAKPKM 1050
AILREQGVNS HVEMAAAFDR AGFEATDIHM SDILTGQAVL EEYNGLVACG 1100
GFSYGDVLGA GEGWAKSVLF NDATRDQFEN FFKREDTFSL GVCNGCQMLS 1150
NLRELIPGAE YWPRFVRNES ERFEARFSLV EVQKSDSVFF NGMEGSRMPI 1200
AVSHGEGRVE VRDNEHLNAI ENSGTVALRY VDNHGNPTQQ YPNNPNGSPN 1250
AITGLTTTDG RVTIMMPHPE RVFRTVANSW SPEGWGENGA WMRMFQNARK 1300
NIG 1303
Length:1,303
Mass (Da):142,216
Last modified:October 14, 2008 - v1
Checksum:i184AEDF17D7D9344
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001139 Genomic DNA. Translation: ACH65476.1.
RefSeqiYP_002155412.1. NC_011184.1.

Genome annotation databases

EnsemblBacteriaiACH65476; ACH65476; VFMJ11_0669.
GeneIDi6806582.
KEGGivfm:VFMJ11_0669.
PATRICi20119801. VBIVibFis37164_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001139 Genomic DNA. Translation: ACH65476.1 .
RefSeqi YP_002155412.1. NC_011184.1.

3D structure databases

ProteinModelPortali B5FAZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388396.VFMJ11_0669.

Protein family/group databases

MEROPSi C56.972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH65476 ; ACH65476 ; VFMJ11_0669 .
GeneIDi 6806582.
KEGGi vfm:VFMJ11_0669.
PATRICi 20119801. VBIVibFis37164_0640.

Phylogenomic databases

eggNOGi COG0046.
HOGENOMi HOG000261359.
KOi K01952.
OMAi GEGHAEF.
OrthoDBi EOG6FNHHR.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00128 .

Family and domain databases

Gene3Di 3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00419. PurL_1.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsi TIGR01735. FGAM_synt. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11.

Entry informationi

Entry nameiB5FAZ8_VIBFM
AccessioniPrimary (citable) accession number: B5FAZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In Gram-negative bacteria and most eukaryotes, FGAM synthase is only formed by PurL, a single polypeptide of 140 kDa (large PurL). However in Gram-positive bacteria and archaebacteria, phosphoribosylformylglycinamidine synthase is composed of three separate proteins: PurL (small PurL), PurQ and PurS By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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