Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861S-adenosyl-L-methionineUniRule annotation
Binding sitei238 – 2381S-adenosyl-L-methionineUniRule annotation
Binding sitei258 – 2581S-adenosyl-L-methionineUniRule annotation
Binding sitei275 – 2751S-adenosyl-L-methionineUniRule annotation
Active sitei304 – 3041Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:VFMJ11_0607
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001857 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Ribosomal RNA large subunit methyltransferase MPRO_1000201535Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5FAT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2224S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FAT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYCRSGFEK ECAGEIQDKA TQLEVFGFPR LKNNTGYVLF ECYQEGDADR
60 70 80 90 100
LIREIKFNEL IFARQMFAVA VEVSDLPKDD RISPILDALS EVEDVPCCGD
110 120 130 140 150
IRIETPDTNE AKELLKFCRK FTVPMRQALR GKKMLTERDS NRIPVLHICF
160 170 180 190 200
IAPGHCYVGY SYTNNNSQFF MGIPRLKFPA DAPSRSTLKL EEAFHVFIPK
210 220 230 240 250
EEWDDRLASG MWGVDLGACP GGWTYQLVKR SMFVHAIDNG MMAQSLMDTG
260 270 280 290 300
QVKHHMVDGF KFEPPRKNVT WLICDMVEKP ARVAHLMGEW LIKGWAKEAL
310 320 330 340 350
FNLKLPMKGR YDEVLQDIEN LKDFLKKNGF QYKLQAKHLY HDREEITVHI

QAISNISPH
Length:359
Mass (Da):41,399
Last modified:October 14, 2008 - v1
Checksum:i5D768653B132BF3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH66175.1.

Genome annotation databases

EnsemblBacteriaiACH66175; ACH66175; VFMJ11_0607.
KEGGivfm:VFMJ11_0607.
PATRICi20119679. VBIVibFis37164_0579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH66175.1.

3D structure databases

ProteinModelPortaliB5FAT6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH66175; ACH66175; VFMJ11_0607.
KEGGivfm:VFMJ11_0607.
PATRICi20119679. VBIVibFis37164_0579.

Phylogenomic databases

HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiPOG091H04R8.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMM_VIBFM
AccessioniPrimary (citable) accession number: B5FAT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.