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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:VFMJ11_0507
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000001857 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001862771 – 443Thymidine phosphorylaseAdd BLAST443

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5FA99
SMRiB5FA99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000047313
KOiK00758
OMAiVHSIGGV
OrthoDBiPOG091H02BC

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

B5FA99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLPQEIIRK KRDNKELTTE EINFFIQGVA KETVSEGQIA AFAMAVYFNE
60 70 80 90 100
MTMPERIALT CAMRDSGMVI DWSHMNFDGP IVDKHSTGGV GDVTSLMLGP
110 120 130 140 150
MVAACGGYVP MISGRGLGHT GGTLDKLESI AGYNITPSND VFGKVTKEAG
160 170 180 190 200
VAIIGQTGDL APADKRVYAT RDVTATVDNI SLITASILSK KLAAGLDSLV
210 220 230 240 250
MDVKVGSGAF MPTYEASEEL AKSIVAVANG AGTKTTALLT DMNQVLASTA
260 270 280 290 300
GNALEVREAI RFLTGEYRNP RLYEVTMALC AEMLVIANLA KDEQDARAKL
310 320 330 340 350
QTVLDNGKAA ECFGKMVFGL GGPSDIIENY DNHLESAQII KPVFADTTGF
360 370 380 390 400
VHAMDTRDLG MAVVGMGGGR RVASDTIDYA VGLSDMIRLG QTADNQQPLA
410 420 430 440
MIHARNEEQW QQAANAVKAA IVISEKQPEA TPEVYRKIRP EDV
Length:443
Mass (Da):47,483
Last modified:October 14, 2008 - v1
Checksum:i1D72DA4C2FFC1084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA Translation: ACH65607.1
RefSeqiWP_012533167.1, NC_011184.1

Genome annotation databases

EnsemblBacteriaiACH65607; ACH65607; VFMJ11_0507
KEGGivfm:VFMJ11_0507

Similar proteinsi

Entry informationi

Entry nameiTYPH_VIBFM
AccessioniPrimary (citable) accession number: B5FA99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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