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Protein

Malate synthase

Gene

aceB

Organism
Vibrio fischeri (strain MJ11)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Proton acceptorUniRule annotation
Active sitei449 – 4491Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:aceBImported
Ordered Locus Names:VFMJ11_2107Imported
OrganismiVibrio fischeri (strain MJ11)Imported
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi388396.VFMJ11_2107.

Structurei

3D structure databases

ProteinModelPortaliB5F9Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5F9Y7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDTMTIKEQ QITITKPHLP QVEEVLTAGA VRFLTHVVEK FAHRVPELLE
60 70 80 90 100
TRQLRQKKID AGQLPNFLSE TRSIRESEWS IQGIPTDLQD RRVEITGPTD
110 120 130 140 150
RKMVINALNA NVKVFMADFE DSLSPSWEAV LNGQINLRDA MDGTIQYTNP
160 170 180 190 200
QTQKVYQLKQ DPAVLICRVR GLHLPEKHVL FNGVAIPGAL FDFALYFYHN
210 220 230 240 250
YQTSLKKGSG PYFYLPKLQA YQEAAWWSDV FSFAEREFGL KQGTIKATVL
260 270 280 290 300
IETLPAVFEM DEILYSLKEH IVGLNCGRWD YIFSYIKTLK NHPDRVLPDR
310 320 330 340 350
QVVTMEKPFL NAYSRLLIRT CHRRGAFAMG GMAAFIPSKD PEQNDWVLNK
360 370 380 390 400
IQTDKSLEAN NGHDGTWVAH PGLADTARAE FDSVLGERMN QLDITRDTDA
410 420 430 440 450
PITAEELLAP CEGERTEEGM RHNIRVAVQY IEAWISGNGC VPIYGLMEDA
460 470 480 490 500
ATAEISRTSI WQWIQHGKTL DSGAVVTAEL FRTMLLEEMK VIEKELGTER
510 520 530
FDSGQFTQAA KLMEQLTTSD QLTDFLTLPG YQYL
Length:534
Mass (Da):60,671
Last modified:October 14, 2008 - v1
Checksum:i640C2DB5A9FB5B93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67187.1.
RefSeqiYP_002156801.1. NC_011184.1.

Genome annotation databases

EnsemblBacteriaiACH67187; ACH67187; VFMJ11_2107.
GeneIDi6806014.
KEGGivfm:VFMJ11_2107.
PATRICi20122678. VBIVibFis37164_2029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001139 Genomic DNA. Translation: ACH67187.1.
RefSeqiYP_002156801.1. NC_011184.1.

3D structure databases

ProteinModelPortaliB5F9Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi388396.VFMJ11_2107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH67187; ACH67187; VFMJ11_2107.
GeneIDi6806014.
KEGGivfm:VFMJ11_2107.
PATRICi20122678. VBIVibFis37164_2029.

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000238464.
KOiK01638.
OMAiMMINALN.
OrthoDBiEOG69WFFX.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11Imported.

Entry informationi

Entry nameiB5F9Y7_VIBFM
AccessioniPrimary (citable) accession number: B5F9Y7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: February 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.