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B5F9W3

- LPXB_VIBFM

UniProt

B5F9W3 - LPXB_VIBFM

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:VFMJ11_2083
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000123068Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388396.VFMJ11_2083.

Structurei

3D structure databases

ProteinModelPortaliB5F9W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B5F9W3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPLRIGIV AGELSGDTLG EGFIKSIKAQ YPDAEFVGIG GPKMIAQGCD
60 70 80 90 100
SLFDMEELAV MGLVEVLGRL PRLLKVKAEL VRYFTQNPPD VFIGIDAPDF
110 120 130 140 150
NLRLEKTLKD NGIKTVHYVS PSVWAWRPKR IFKIDAATDL VLAFLPFEKA
160 170 180 190 200
FYDKYNVACE FIGHTLADAI PMETDKFAAR ELLGLEQDRK WLAVLPGSRG
210 220 230 240 250
GEVALIAKPF IETCQRIHKQ HPDMGFVVAA VNEKRREQFE TIWKETAPEL
260 270 280 290 300
DFVIIQDTAR NVMTAADAVL LASGTVALEC MLVKRPMVVG YQVNKLTGWI
310 320 330 340 350
AQKLSITEFV SLPNVLAGKE LVQEFIQEEC HPDFLYPAME KVLDNDNSEL
360 370 380
IEKFTEMHQW IRKDADKQAA NAVLRLINKE TAE
Length:383
Mass (Da):42,982
Last modified:October 14, 2008 - v1
Checksum:i10D9040A226338A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001139 Genomic DNA. Translation: ACH66387.1.
RefSeqiYP_002156777.1. NC_011184.1.

Genome annotation databases

EnsemblBacteriaiACH66387; ACH66387; VFMJ11_2083.
GeneIDi6806746.
KEGGivfm:VFMJ11_2083.
PATRICi20122630. VBIVibFis37164_2005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001139 Genomic DNA. Translation: ACH66387.1 .
RefSeqi YP_002156777.1. NC_011184.1.

3D structure databases

ProteinModelPortali B5F9W3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388396.VFMJ11_2083.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH66387 ; ACH66387 ; VFMJ11_2083 .
GeneIDi 6806746.
KEGGi vfm:VFMJ11_2083.
PATRICi 20122630. VBIVibFis37164_2005.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11.

Entry informationi

Entry nameiLPXB_VIBFM
AccessioniPrimary (citable) accession number: B5F9W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3