Skip Header

Contribute Send feedback
Read comments (?) or add your own

B5F6C2 (KHSE_SALA4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:SeAg_B0003
OrganismSalmonella agona (strain SL483) [Complete proteome] [HAMAP]
Taxonomic identifier454166 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Homoserine kinase HAMAP-Rule MF_00384
PRO_1000122436

Regions

Nucleotide binding91 – 10111ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B5F6C2 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 2B5D570CB35F8911

FASTA30933,286
        10         20         30         40         50         60 
MVKVYAPASS ANMSVGFDVL GAAVTPVDGT LLGDVVSVEA ADHFRLHNLG RFADKLPPEP 

        70         80         90        100        110        120 
RENIVYQCWE RFCQALGKTI PVAMTLEKNM PIGSGLGSSA CSVVAALVAM NEHCGKPLND 

       130        140        150        160        170        180 
TRLLALMGEL EGRISGSIHY DNVAPCFLGG MQLMIEENGI ISQQVPGFDE WLWVLAYPGI 

       190        200        210        220        230        240 
KVSTAEARAI LPAQYRRQDC IAHGRHLAGF IHACYSRQPQ LAAALMKDVI AEPYRARLLP 

       250        260        270        280        290        300 
GFSQARQAVS EIGALASGIS GSGPTLFALC DKPETAQRVA DWLSKHYLQN QEGFVHICRL 


DTAGARVVG

« Hide

References

[1]"Complete genome of Salmonella agona strain SL483."
Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SL483.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001138 Genomic DNA. Translation: ACH51034.1.
RefSeqYP_002144981.1. NC_011149.1.

3D structure databases

ProteinModelPortalB5F6C2.
ModBaseSearch...

Protein-protein interaction databases

STRING454166.SeAg_B0003.

Proteomic databases

PRIDEB5F6C2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH51034; ACH51034; SeAg_B0003.
GeneID6793870.
KEGGsea:SeAg_B0003.
PATRIC18478394. VBISalEnt65316_0040.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247198.
KOK00872.
OMAGFVHICK.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycSENT454166:GHBA-2669-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_SALA4
AccessionPrimary (citable) accession number: B5F6C2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents