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B5EZH0

- RHMD_SALA4

UniProt

B5EZH0 - RHMD_SALA4

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Protein

L-rhamnonate dehydratase

Gene
rhmD, SeAg_B2427
Organism
Salmonella agona (strain SL483)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR) By similarity.UniRule annotation

Catalytic activityi

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291Substrate By similarity
Binding sitei55 – 551Substrate By similarity
Metal bindingi222 – 2221Magnesium By similarity
Metal bindingi248 – 2481Magnesium By similarity
Metal bindingi276 – 2761Magnesium By similarity
Sitei298 – 2981Increases basicity of active site His By similarity
Active sitei325 – 3251Proton acceptor By similarity
Binding sitei345 – 3451Substrate By similarity
Sitei345 – 3451Transition state stabilizer By similarity

GO - Molecular functioni

  1. L-rhamnonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT454166:GHBA-2405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnonate dehydratase (EC:4.2.1.90)
Short name:
RhamD
Gene namesi
Name:rhmD
Ordered Locus Names:SeAg_B2427
OrganismiSalmonella agona (strain SL483)
Taxonomic identifieri454166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008819: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401L-rhamnonate dehydrataseUniRule annotationPRO_1000165262Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi454166.SeAg_B2427.

Structurei

3D structure databases

ProteinModelPortaliB5EZH0.
SMRiB5EZH0. Positions 1-401.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4948.
HOGENOMiHOG000113755.
OMAiFCVELEA.
OrthoDBiEOG68Q0M0.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01288. Rhamnon_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5EZH0-1 [UniParc]FASTAAdd to Basket

« Hide

MTLPKIKHVR AWFIGGATAE KGAGGGDYHD QGGNHWIDDH IATPMSKYRD    50
YEQSRQSFGI NVLGTLIVEV EAENGQTGFA VSTAGEMGCF IVEKHLNRFI 100
EGKCVSDIKL IHDQMLGATM YYSGSGGLVM NTISCVDLAL WDLFGKVVGL 150
PVYKLLGGAV RDEIQFYATG ARPDLAKEMG FIGGKMPTHW GPHDGDAGIR 200
KDAAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PFNLKWIEEC 250
LPPQQYEGYR ELKRNAPAGM MVTSGEHHGT LQSFRTLAET GIDIMQPDVG 300
WCGGLTTLVE IAALAKSRGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS 350
PDCSTLRPQF DPILLDEPVP VNGRIHKSVL DKPGFGVELN RDCHLKRPYS 400
H 401
Length:401
Mass (Da):44,119
Last modified:October 14, 2008 - v1
Checksum:i1B66DC07F01C2CA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001138 Genomic DNA. Translation: ACH52764.1.
RefSeqiYP_002147247.1. NC_011149.1.

Genome annotation databases

EnsemblBacteriaiACH52764; ACH52764; SeAg_B2427.
PATRICi18483140. VBISalEnt65316_2376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001138 Genomic DNA. Translation: ACH52764.1 .
RefSeqi YP_002147247.1. NC_011149.1.

3D structure databases

ProteinModelPortali B5EZH0.
SMRi B5EZH0. Positions 1-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 454166.SeAg_B2427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH52764 ; ACH52764 ; SeAg_B2427 .
PATRICi 18483140. VBISalEnt65316_2376.

Phylogenomic databases

eggNOGi COG4948.
HOGENOMi HOG000113755.
OMAi FCVELEA.
OrthoDBi EOG68Q0M0.

Enzyme and pathway databases

BioCyci SENT454166:GHBA-2405-MONOMER.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_01288. Rhamnon_dehydrat.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL483.

Entry informationi

Entry nameiRHMD_SALA4
AccessioniPrimary (citable) accession number: B5EZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via a syn dehydration By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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