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B5EZH0

- RHMD_SALA4

UniProt

B5EZH0 - RHMD_SALA4

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Protein

L-rhamnonate dehydratase

Gene

rhmD

Organism
Salmonella agona (strain SL483)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).UniRule annotation

Catalytic activityi

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291SubstrateUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Metal bindingi222 – 2221MagnesiumUniRule annotation
Metal bindingi248 – 2481MagnesiumUniRule annotation
Metal bindingi276 – 2761MagnesiumUniRule annotation
Sitei298 – 2981Increases basicity of active site HisUniRule annotation
Active sitei325 – 3251Proton acceptorUniRule annotation
Binding sitei345 – 3451SubstrateUniRule annotation
Sitei345 – 3451Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. L-rhamnonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT454166:GHBA-2405-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnonate dehydrataseUniRule annotation (EC:4.2.1.90UniRule annotation)
Short name:
RhamDUniRule annotation
Gene namesi
Name:rhmDUniRule annotation
Ordered Locus Names:SeAg_B2427
OrganismiSalmonella agona (strain SL483)
Taxonomic identifieri454166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008819: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401L-rhamnonate dehydratasePRO_1000165262Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi454166.SeAg_B2427.

Structurei

3D structure databases

ProteinModelPortaliB5EZH0.
SMRiB5EZH0. Positions 1-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4948.
HOGENOMiHOG000113755.
OMAiFCVELEA.
OrthoDBiEOG68Q0M0.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01288. Rhamnon_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5EZH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLPKIKHVR AWFIGGATAE KGAGGGDYHD QGGNHWIDDH IATPMSKYRD
60 70 80 90 100
YEQSRQSFGI NVLGTLIVEV EAENGQTGFA VSTAGEMGCF IVEKHLNRFI
110 120 130 140 150
EGKCVSDIKL IHDQMLGATM YYSGSGGLVM NTISCVDLAL WDLFGKVVGL
160 170 180 190 200
PVYKLLGGAV RDEIQFYATG ARPDLAKEMG FIGGKMPTHW GPHDGDAGIR
210 220 230 240 250
KDAAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PFNLKWIEEC
260 270 280 290 300
LPPQQYEGYR ELKRNAPAGM MVTSGEHHGT LQSFRTLAET GIDIMQPDVG
310 320 330 340 350
WCGGLTTLVE IAALAKSRGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS
360 370 380 390 400
PDCSTLRPQF DPILLDEPVP VNGRIHKSVL DKPGFGVELN RDCHLKRPYS

H
Length:401
Mass (Da):44,119
Last modified:October 14, 2008 - v1
Checksum:i1B66DC07F01C2CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001138 Genomic DNA. Translation: ACH52764.1.
RefSeqiYP_002147247.1. NC_011149.1.

Genome annotation databases

EnsemblBacteriaiACH52764; ACH52764; SeAg_B2427.
PATRICi18483140. VBISalEnt65316_2376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001138 Genomic DNA. Translation: ACH52764.1 .
RefSeqi YP_002147247.1. NC_011149.1.

3D structure databases

ProteinModelPortali B5EZH0.
SMRi B5EZH0. Positions 1-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 454166.SeAg_B2427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH52764 ; ACH52764 ; SeAg_B2427 .
PATRICi 18483140. VBISalEnt65316_2376.

Phylogenomic databases

eggNOGi COG4948.
HOGENOMi HOG000113755.
OMAi FCVELEA.
OrthoDBi EOG68Q0M0.

Enzyme and pathway databases

BioCyci SENT454166:GHBA-2405-MONOMER.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_01288. Rhamnon_dehydrat.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023444. L-Rhamnon_dehydrat.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SL483.

Entry informationi

Entry nameiRHMD_SALA4
AccessioniPrimary (citable) accession number: B5EZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via a syn dehydration.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3