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Protein

L-rhamnonate dehydratase

Gene

rhmD

Organism
Salmonella agona (strain SL483)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).UniRule annotation

Miscellaneous

Reaction proceeds via a syn dehydration.UniRule annotation

Catalytic activityi

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29SubstrateUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi222MagnesiumUniRule annotation1
Metal bindingi248MagnesiumUniRule annotation1
Metal bindingi276MagnesiumUniRule annotation1
Sitei298Increases basicity of active site HisUniRule annotation1
Active sitei325Proton acceptorUniRule annotation1
Binding sitei345SubstrateUniRule annotation1
Sitei345Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnonate dehydrataseUniRule annotation (EC:4.2.1.90UniRule annotation)
Short name:
RhamDUniRule annotation
Gene namesi
Name:rhmDUniRule annotation
Ordered Locus Names:SeAg_B2427
OrganismiSalmonella agona (strain SL483)
Taxonomic identifieri454166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008819 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001652621 – 401L-rhamnonate dehydrataseAdd BLAST401

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5EZH0
SMRiB5EZH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000113755
KOiK12661
OMAiNINWWEE

Family and domain databases

Gene3Di3.20.20.120, 1 hit
3.30.390.10, 1 hit
HAMAPiMF_01288 Rhamnon_dehydrat, 1 hit
InterProiView protein in InterPro
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR029065 Enolase_C-like
IPR023444 L-Rhamnon_dehydrat
IPR018110 Mandel_Rmase/mucon_lact_enz_CS
IPR034593 Mandelate_racemase-like
IPR013342 Mandelate_racemase_C
IPR013341 Mandelate_racemase_N_dom
PANTHERiPTHR13794:SF59 PTHR13794:SF59, 1 hit
PfamiView protein in Pfam
PF13378 MR_MLE_C, 1 hit
PF02746 MR_MLE_N, 1 hit
SFLDiSFLDF00006 rhamnonate_dehydratase, 1 hit
SFLDG00179 mandelate_racemase, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM00922 MR_MLE, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
PROSITEiView protein in PROSITE
PS00908 MR_MLE_1, 1 hit

Sequencei

Sequence statusi: Complete.

B5EZH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPKIKHVR AWFIGGATAE KGAGGGDYHD QGGNHWIDDH IATPMSKYRD
60 70 80 90 100
YEQSRQSFGI NVLGTLIVEV EAENGQTGFA VSTAGEMGCF IVEKHLNRFI
110 120 130 140 150
EGKCVSDIKL IHDQMLGATM YYSGSGGLVM NTISCVDLAL WDLFGKVVGL
160 170 180 190 200
PVYKLLGGAV RDEIQFYATG ARPDLAKEMG FIGGKMPTHW GPHDGDAGIR
210 220 230 240 250
KDAAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PFNLKWIEEC
260 270 280 290 300
LPPQQYEGYR ELKRNAPAGM MVTSGEHHGT LQSFRTLAET GIDIMQPDVG
310 320 330 340 350
WCGGLTTLVE IAALAKSRGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS
360 370 380 390 400
PDCSTLRPQF DPILLDEPVP VNGRIHKSVL DKPGFGVELN RDCHLKRPYS

H
Length:401
Mass (Da):44,119
Last modified:October 14, 2008 - v1
Checksum:i1B66DC07F01C2CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001138 Genomic DNA Translation: ACH52764.1

Genome annotation databases

EnsemblBacteriaiACH52764; ACH52764; SeAg_B2427
KEGGisea:SeAg_B2427

Similar proteinsi

Entry informationi

Entry nameiRHMD_SALA4
AccessioniPrimary (citable) accession number: B5EZH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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