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B5EZH0

- RHMD_SALA4

UniProt

B5EZH0 - RHMD_SALA4

Protein

L-rhamnonate dehydratase

Gene

rhmD

Organism
Salmonella agona (strain SL483)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).UniRule annotation

    Catalytic activityi

    L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291SubstrateUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Metal bindingi222 – 2221MagnesiumUniRule annotation
    Metal bindingi248 – 2481MagnesiumUniRule annotation
    Metal bindingi276 – 2761MagnesiumUniRule annotation
    Sitei298 – 2981Increases basicity of active site HisUniRule annotation
    Active sitei325 – 3251Proton acceptorUniRule annotation
    Binding sitei345 – 3451SubstrateUniRule annotation
    Sitei345 – 3451Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. L-rhamnonate dehydratase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular amino acid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT454166:GHBA-2405-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-rhamnonate dehydrataseUniRule annotation (EC:4.2.1.90UniRule annotation)
    Short name:
    RhamDUniRule annotation
    Gene namesi
    Name:rhmDUniRule annotation
    Ordered Locus Names:SeAg_B2427
    OrganismiSalmonella agona (strain SL483)
    Taxonomic identifieri454166 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008819: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401L-rhamnonate dehydratasePRO_1000165262Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi454166.SeAg_B2427.

    Structurei

    3D structure databases

    ProteinModelPortaliB5EZH0.
    SMRiB5EZH0. Positions 1-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4948.
    HOGENOMiHOG000113755.
    OMAiFCVELEA.
    OrthoDBiEOG68Q0M0.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPiMF_01288. Rhamnon_dehydrat.
    InterProiIPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR023444. L-Rhamnon_dehydrat.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEiPS00908. MR_MLE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5EZH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLPKIKHVR AWFIGGATAE KGAGGGDYHD QGGNHWIDDH IATPMSKYRD    50
    YEQSRQSFGI NVLGTLIVEV EAENGQTGFA VSTAGEMGCF IVEKHLNRFI 100
    EGKCVSDIKL IHDQMLGATM YYSGSGGLVM NTISCVDLAL WDLFGKVVGL 150
    PVYKLLGGAV RDEIQFYATG ARPDLAKEMG FIGGKMPTHW GPHDGDAGIR 200
    KDAAMVADMR EKCGPDFWLM LDCWMSQDVN YATKLAHACA PFNLKWIEEC 250
    LPPQQYEGYR ELKRNAPAGM MVTSGEHHGT LQSFRTLAET GIDIMQPDVG 300
    WCGGLTTLVE IAALAKSRGQ LVVPHGSSVY SHHAVITFTN TPFSEFLMTS 350
    PDCSTLRPQF DPILLDEPVP VNGRIHKSVL DKPGFGVELN RDCHLKRPYS 400
    H 401
    Length:401
    Mass (Da):44,119
    Last modified:October 14, 2008 - v1
    Checksum:i1B66DC07F01C2CA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001138 Genomic DNA. Translation: ACH52764.1.
    RefSeqiYP_002147247.1. NC_011149.1.

    Genome annotation databases

    EnsemblBacteriaiACH52764; ACH52764; SeAg_B2427.
    PATRICi18483140. VBISalEnt65316_2376.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001138 Genomic DNA. Translation: ACH52764.1 .
    RefSeqi YP_002147247.1. NC_011149.1.

    3D structure databases

    ProteinModelPortali B5EZH0.
    SMRi B5EZH0. Positions 1-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 454166.SeAg_B2427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH52764 ; ACH52764 ; SeAg_B2427 .
    PATRICi 18483140. VBISalEnt65316_2376.

    Phylogenomic databases

    eggNOGi COG4948.
    HOGENOMi HOG000113755.
    OMAi FCVELEA.
    OrthoDBi EOG68Q0M0.

    Enzyme and pathway databases

    BioCyci SENT454166:GHBA-2405-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    HAMAPi MF_01288. Rhamnon_dehydrat.
    InterProi IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR023444. L-Rhamnon_dehydrat.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    PROSITEi PS00908. MR_MLE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SL483.

    Entry informationi

    Entry nameiRHMD_SALA4
    AccessioniPrimary (citable) accession number: B5EZH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Reaction proceeds via a syn dehydration.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3