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B5EUH1

- GCSP_VIBFM

UniProt

B5EUH1 - GCSP_VIBFM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, VFMJ11_A0790
Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VFMJ11_A0790
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi388396.VFMJ11_A0790.

Structurei

3D structure databases

ProteinModelPortaliB5EUH1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EUH1-1 [UniParc]FASTAAdd to Basket

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MSQLLQQLGT DNEFIRRHNG PASSEHQHML NTIGAETLQQ LIEETVPSSI    50
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR 100
NVLENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL EIANASLLDE 150
ATAAAEAMTL CKRGGKSKSN IFFVADDVHP QTLAVIKTRA KFIGFDVIVD 200
NESNLDSHDV FGALLQYPGT TGEVKDLTDL IAQAHTKKTL VVVATDLLAS 250
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI 300
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH 350
GPEGLKTIAR RVHHFTAIVA KALQTAGFEL EHQHFFDTLT VKTEQQTDIL 400
YTKALASSIN LRKFDTKLGI SFDETTTVSD LVTLLAVFGI DNAECETLSA 450
EVGKDEFAAI PKHCQRTSSF LTHPVFNTYH SETQMLRYLK KLENKDFSLT 500
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK 550
SMLCEITGYD EFSLQPNSGA SGEYAGLIAI QRYHESRGDA HRNVCLIPSS 600
AHGTNPATAS MVSMKVVVVK CDENGNIDMI DLAEKIEKHQ ENLSSIMITY 650
PSTHGVYEEQ VREVCDMVHA AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH 700
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHTENGVQ GTDYAVSAAD 750
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMERL RPHYPVLYRG 800
SNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM 850
VEPTESEDLA ELDRFCDAMI AIREEMHKVE QGEWPLDNNP LVNAPHTQVD 900
LMSDSWDHPY TREVACFPSS QSKDSKYWPT VNRVDNVYGD RNLICSCPSI 950
ENYEE 955
Length:955
Mass (Da):104,739
Last modified:October 14, 2008 - v1
Checksum:i06414DBC44925621
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001133 Genomic DNA. Translation: ACH64611.1.
RefSeqiYP_002158339.1. NC_011186.1.

Genome annotation databases

EnsemblBacteriaiACH64611; ACH64611; VFMJ11_A0790.
GeneIDi6808041.
KEGGivfm:VFMJ11_A0790.
PATRICi20125812. VBIVibFis37164_3530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001133 Genomic DNA. Translation: ACH64611.1 .
RefSeqi YP_002158339.1. NC_011186.1.

3D structure databases

ProteinModelPortali B5EUH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388396.VFMJ11_A0790.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH64611 ; ACH64611 ; VFMJ11_A0790 .
GeneIDi 6808041.
KEGGi vfm:VFMJ11_A0790.
PATRICi 20125812. VBIVibFis37164_3530.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11.

Entry informationi

Entry nameiGCSP_VIBFM
AccessioniPrimary (citable) accession number: B5EUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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