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B5EUH1

- GCSP_VIBFM

UniProt

B5EUH1 - GCSP_VIBFM

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VFMJ11_A0790
OrganismiVibrio fischeri (strain MJ11)
Taxonomic identifieri388396 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
ProteomesiUP000001857: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000132461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi388396.VFMJ11_A0790.

Structurei

3D structure databases

ProteinModelPortaliB5EUH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EUH1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSQLLQQLGT DNEFIRRHNG PASSEHQHML NTIGAETLQQ LIEETVPSSI
60 70 80 90 100
RLPQPMQLPH GLSENAMLAE LKQIAQQNTL NTSYIGQGYY NTHTPNVILR
110 120 130 140 150
NVLENPGWYT AYTPYQPEIS QGRLEALLNY QQMVMDLTGL EIANASLLDE
160 170 180 190 200
ATAAAEAMTL CKRGGKSKSN IFFVADDVHP QTLAVIKTRA KFIGFDVIVD
210 220 230 240 250
NESNLDSHDV FGALLQYPGT TGEVKDLTDL IAQAHTKKTL VVVATDLLAS
260 270 280 290 300
VLLKPVGEMG ADIAIGSAQR FGVPMGYGGP HAAFMATREK LKRSMPGRVI
310 320 330 340 350
GVSIDSKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH
360 370 380 390 400
GPEGLKTIAR RVHHFTAIVA KALQTAGFEL EHQHFFDTLT VKTEQQTDIL
410 420 430 440 450
YTKALASSIN LRKFDTKLGI SFDETTTVSD LVTLLAVFGI DNAECETLSA
460 470 480 490 500
EVGKDEFAAI PKHCQRTSSF LTHPVFNTYH SETQMLRYLK KLENKDFSLT
510 520 530 540 550
HGMIPLGSCT MKLNAVAEML PVTWPEFGGI HPFAPLNQAA GYTTLATSLK
560 570 580 590 600
SMLCEITGYD EFSLQPNSGA SGEYAGLIAI QRYHESRGDA HRNVCLIPSS
610 620 630 640 650
AHGTNPATAS MVSMKVVVVK CDENGNIDMI DLAEKIEKHQ ENLSSIMITY
660 670 680 690 700
PSTHGVYEEQ VREVCDMVHA AGGQVYLDGA NMNAQVGLTS PGFIGSDVSH
710 720 730 740 750
LNLHKTFCIP HGGGGPGMGP IGVKSHLAPF LPGHTENGVQ GTDYAVSAAD
760 770 780 790 800
LGSASILPIS WAYIAMMGEM GLTEATKVAI LNANYVMERL RPHYPVLYRG
810 820 830 840 850
SNGRIAHECI IDIRPLKEAT GISEEDIAKR LMDFGFHAPT MSFPVAGTLM
860 870 880 890 900
VEPTESEDLA ELDRFCDAMI AIREEMHKVE QGEWPLDNNP LVNAPHTQVD
910 920 930 940 950
LMSDSWDHPY TREVACFPSS QSKDSKYWPT VNRVDNVYGD RNLICSCPSI

ENYEE
Length:955
Mass (Da):104,739
Last modified:October 14, 2008 - v1
Checksum:i06414DBC44925621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001133 Genomic DNA. Translation: ACH64611.1.
RefSeqiYP_002158339.1. NC_011186.1.

Genome annotation databases

EnsemblBacteriaiACH64611; ACH64611; VFMJ11_A0790.
GeneIDi6808041.
KEGGivfm:VFMJ11_A0790.
PATRICi20125812. VBIVibFis37164_3530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001133 Genomic DNA. Translation: ACH64611.1 .
RefSeqi YP_002158339.1. NC_011186.1.

3D structure databases

ProteinModelPortali B5EUH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388396.VFMJ11_A0790.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH64611 ; ACH64611 ; VFMJ11_A0790 .
GeneIDi 6808041.
KEGGi vfm:VFMJ11_A0790.
PATRICi 20125812. VBIVibFis37164_3530.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Vibrio fischeri strain MJ11."
    Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ11.

Entry informationi

Entry nameiGCSP_VIBFM
AccessioniPrimary (citable) accession number: B5EUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3