Reviewed, UniProtKB/Swiss-Prot B5ERI2 (TRPC_ACIF5)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Lferr_2843

Organism

Acidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993)) [Complete proteome] [HAMAP]

Taxonomic identifier

380394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000095848

Sequences

	Sequence		Length	Mass (Da)
	B5ERI2-1 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: D56A423203F74555	FASTA	263	28,695
	10 20 30 40 50 60 MTDILQEIIA HKREELVERQ TRLGLAELQA AVALTAPPRN FVGAVRARMA QGQPAVIAEI 70 80 90 100 110 120 KKASPSAGVI REDFNPVTIA QDYAAHGAAC LSVLTDEHYF QGADLYLAAA REACPLPVLR 130 140 150 160 170 180 KDFCIDPYQV WEARAIGADA ILLIVAALSD AELQSLEATA QSLDLAVLVE VHDAAELQRA 190 200 210 220 230 240 LKLRTPLIGI NNRDLRRFVT EIETTLKLLP EIPRERIVVT ESGIRSREEV ATLRAAGVGA 250 260 FLVGEAFMRT AQPGDALQHL FFD

References

[1]

"Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Borole A.P. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001132 Genomic DNA. Translation: ACH85028.1.
RefSeq	YP_002221235.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6878847.
GenomeReviews	Gene locus Lferr_2843 in contig CP001132_GR.
KEGG	afe:Lferr_2843.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PLLCKDF.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ACIF5

Accession

Primary (citable) accession number: B5ERI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	October 14, 2008
Last modified:	November 3, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)