B5EQR3 (B5EQR3_ACIF5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ACH83413.1
EC=2.4.1.182 EMBL ACH83413.1

Gene names

Ordered Locus Names:

Lferr_1175

Organism

Acidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993)) [Complete proteome] [HAMAP]

Taxonomic identifier

380394 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ACH83413.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5EQR3 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 8FF7BB1A9EEE9C35	FASTA	375	41,102
	10 20 30 40 50 60 MGKAFILAVE RSGENLGLEI LANAAQAGLD LQWSGVVGSR LQAAGVQNIA NGEVLAMIGL 70 80 90 100 110 120 VEVLRHYGRL RRLYGQIRQH LQAERPACVV LIDHPAFNLH VAKMAKQMGI RVLYVVGPQI 130 140 150 160 170 180 WAWRSQRIHQ IKRVVDHMLV LFPFEVPIYA QAGVPVHVLA HPLLAQTATA QDGMDARAAL 190 200 210 220 230 240 GLTAGGPVLA LLPGSRRGEL ERLTLRYAET ARRLRKQIPD LRILVALARE ELRPLWERLW 250 260 270 280 290 300 KQGAGPEDAQ LVVAQTQTVL AAADVVLVAS GTATLETALM RRPAVVVYIL NALTFAFVRR 310 320 330 340 350 360 LVKTPFVAMP NILLQEAVYP EFLQEAFEPA QVADALAALL GPAGSEQVAK LQKLRSLLEG 370 NPPEQLQQVL REMLA

References

[1]

"Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Borole A.P. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 53993.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001132 Genomic DNA. Translation: ACH83413.1.
RefSeq	YP_002219620.1. NC_011206.1.
3D structure databases
ProteinModelPortal	B5EQR3.
ModBase	Search...
Protein-protein interaction databases
STRING	B5EQR3.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6877148.
GenomeReviews	Gene locus Lferr_1175 in contig CP001132_GR.
KEGG	afe:Lferr_1175.
PATRIC	20659962. VBIAciFer6930_1186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	CLSK2407851.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5EQR3_ACIF5

Accession

Primary (citable) accession number: B5EQR3

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)