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Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Acidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 40C4-typeUniRule annotationAdd BLAST26
Nucleotide bindingi119 – 126ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
Gene namesi
Name:clpXUniRule annotation
Ordered Locus Names:Lferr_1032
OrganismiAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Taxonomic identifieri380394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAcidithiobacilliaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
Proteomesi
  • UP000001856 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001896731 – 423ATP-dependent Clp protease ATP-binding subunit ClpXAdd BLAST423

Interactioni

Subunit structurei

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi380394.Lferr_1032.

Structurei

3D structure databases

SMRiB5EQ29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 40C4-typeUniRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4105CHN. Bacteria.
COG1219. LUCA.
HOGENOMiHOG000010093.
KOiK03544.
OMAiDIMYDLP.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00175. ClpX. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
PANTHERiPTHR11262. PTHR11262. 2 hits.
PfamiView protein in Pfam
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00382. clpX. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EQ29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKHEGSGE KTLYCSFCGK SQHEVRKLIA GPSVFICDEC IELCNDIVKD
60 70 80 90 100
EILDDHSEAQ DKLPKPMEIR KTLDDYVIGQ DVAKKVLSVA VYNHYKRLEH
110 120 130 140 150
GGKDNEVELD KSNILLIGPT GSGKTLLAQT LARLLNVPFA MADATTLTEA
160 170 180 190 200
GYVGEDVENI IQKLLQKCDY DVEKAQTGIV YIDEIDKITR KSENPSITRD
210 220 230 240 250
VSGEGVQQAL LKLIEGTVAS VPPQGGRKHP QQEFLQVDTR HILFICGGAF
260 270 280 290 300
AGLEKSVSAR LEKGGMGFNA PLKRRDKEAT AAMLMQNLEP EDLVRYGLIP
310 320 330 340 350
EFVGRLPILA LLEELDEEAL ISILTDPKNA LVKQYQKLFA LEGVTLEFRT
360 370 380 390 400
EALRAIAKKA LARKTGARGL RSILEQILLD TMYELPSMSG VKKVVVDAAV
410 420
VESGTKPLLV YDDAAKVDMS HPA
Length:423
Mass (Da):46,457
Last modified:October 14, 2008 - v1
Checksum:i56FF9D17B1519B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001132 Genomic DNA. Translation: ACH83274.1.
RefSeqiWP_012536430.1. NC_011206.1.

Genome annotation databases

EnsemblBacteriaiACH83274; ACH83274; Lferr_1032.
KEGGiafe:Lferr_1032.

Similar proteinsi

Entry informationi

Entry nameiCLPX_ACIF5
AccessioniPrimary (citable) accession number: B5EQ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families