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B5EP40 (AROB_ACIF5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:Lferr_0881
OrganismAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993)) [Complete proteome] [HAMAP]
Taxonomic identifier380394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3643643-dehydroquinate synthase HAMAP MF_00110
PRO_1000094443

Sequences

Sequence LengthMass (Da)Tools
B5EP40 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 9A4FF1B9C0BD2F3B

FASTA36438,695
        10         20         30         40         50         60 
MRSLCVDLGQ RSYPIHTGTG ILADSALFAP ALSKGPVAVV TDSNVAPLYL ETLQKTLKAL 

        70         80         90        100        110        120 
DKPSLSIILP AGEESKSLDN IQEIAGRLLS AGYGRDCTLC ALGGGVVGDI TGFAAAVYQR 

       130        140        150        160        170        180 
GVAYIQVPTT LLAMVDSSVG GKTGVNHPLG KNMIGAFYQP QAVIADTDTL DSLPEREFRS 

       190        200        210        220        230        240 
GLAEVIKYGL INDQGFFSWL EDHMDAVLAR EPDALTKVIR HSCKDKADIV ARDELEGGLR 

       250        260        270        280        290        300 
AILNLGHTFG HAIEAATGYG QYLHGEAVAI GMVMAADLSR RLDLIRESEQ DRIYALVEAT 

       310        320        330        340        350        360 
GLPTLAPALP VADYLGFMRV DKKAEGGRVR FILLRGIGSA VITGEVPPAA ITQTLQAFME 


HGHA

« Hide

References

[1]"Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Borole A.P.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 53993.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001132 Genomic DNA. Translation: ACH83131.1.
RefSeqYP_002219338.1. NC_011206.1.

3D structure databases

ProteinModelPortalB5EP40.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5EP40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6876846.
GenomeReviewsGene locus Lferr_0881 in contig CP001132_GR.
KEGGafe:Lferr_0881.
PATRIC20659340. VBIAciFer6930_0882.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBCLSK2407666.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ACIF5
AccessionPrimary (citable) accession number: B5EP40
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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