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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Acidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei252ATPUniRule annotation1
Binding sitei318ATPUniRule annotation1
Binding sitei390ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 65ATPUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:Lferr_2368
OrganismiAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Taxonomic identifieri380394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAcidithiobacilliaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
Proteomesi
  • UP000001856 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001009291 – 440ATP-dependent protease ATPase subunit HslUAdd BLAST440

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi380394.Lferr_2368.

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4N. Bacteria.
COG1220. LUCA.
HOGENOMiHOG000010036.
KOiK03667.
OMAiKYGMIKT.
OrthoDBiPOG091H01U4.

Family and domain databases

HAMAPiMF_00249. HslU. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
PANTHERiPTHR43815. PTHR43815. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

B5ENS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMTPREIV QELDKYIIGQ SEAKRAVAIA LRNRWRRGQV PPPLHQEITP
60 70 80 90 100
KNILMIGPTG VGKTEIARRL AQLANAPFIK VEATKFTEVG YVGKDVESII
110 120 130 140 150
RDLTETAVDM IRNERQVALR QRAEELAEER ILDILIPGPR DSSVPRSDEG
160 170 180 190 200
TRQKFRKMLR EGKLDAQEIE IEVSAPKGGV EIMAPAGMEE MTNQLREMFS
210 220 230 240 250
NMAPGKTSTR RVTVSEAQRL LTDDEAAKLV NEEEVRALAL ERVQSGGIVF
260 270 280 290 300
IDEIDKVAVR SGTQQGSDVS REGVQRDLLP LVEGSNVSTR YGVVKTDHIL
310 320 330 340 350
FIASGAFHLS KPSDLIPELQ GRLPIRVELE ALSAADLVRI LQEPENALVR
360 370 380 390 400
QYGALLASDG LALHFTQDGV QRIAEIAQQV NERVENIGAR RLHTVMERLL
410 420 430 440
EEVAFVAPDG STTALEVDAA YVDSRLKDLA QDEDLSRYIL
Length:440
Mass (Da):48,864
Last modified:October 14, 2008 - v1
Checksum:iB0F696F0B3BD6B85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001132 Genomic DNA. Translation: ACH84569.1.
RefSeqiWP_012537366.1. NC_011206.1.

Genome annotation databases

EnsemblBacteriaiACH84569; ACH84569; Lferr_2368.
KEGGiafe:Lferr_2368.

Similar proteinsi

Entry informationi

Entry nameiHSLU_ACIF5
AccessioniPrimary (citable) accession number: B5ENS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families