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Protein

60 kDa chaperonin

Gene

groL

Organism
Acidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60
Gene namesi
Name:groL
Synonyms:groEL
Ordered Locus Names:Lferr_0698
OrganismiAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993))
Taxonomic identifieri380394 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAcidithiobacilliaAcidithiobacillalesAcidithiobacillaceaeAcidithiobacillus
Proteomesi
  • UP000001856 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001299631 – 55160 kDa chaperoninAdd BLAST551

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.

Protein-protein interaction databases

STRINGi380394.Lferr_0698.

Structurei

3D structure databases

SMRiB5EN19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.
OrthoDBiPOG091H00E7.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EN19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKQVAFAE HAREKMLRGV NVLADAVKVT LGPKGRNVVL DKSFGAPTIT
60 70 80 90 100
KDGVSVAKEI ELADKFENMG AQMVKEVASQ ASDEAGDGTT TATVLAQAII
110 120 130 140 150
REGLKAVIAG MNPMDLKRGI DKSVIVVVEE LKKQSKPCKT QKEVAQVGTI
160 170 180 190 200
SANSDDSIGK IIAEAMEKVG NEGVITVEEG SGLANELDVV EGMQFDRGYL
210 220 230 240 250
SPYFVNNQDK MVAELENPYI LLHDKKISSI RDMLPILEQV AKSSRPLLIV
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI IKVAAVKAPG FGDRRKAMLE DMAILTGGRV
310 320 330 340 350
VSEEIGMKLE STTLADLGQA KKIVIDKENT TMIDGAGQQS EIKARVEQIR
360 370 380 390 400
RQMEDASSDY DREKLQERVA KLAGGVAVIK VGAGSEMEMK EKKARVEDAL
410 420 430 440 450
HATRAAVEEG IVPGGGVALV RARHALEGFK TANHDQDMGV AIIRRAIEEP
460 470 480 490 500
LRQIVANAGG EGSVVLNKVV DGKDGYGYNA ATDEYGDMFE MGVIDPTKVT
510 520 530 540 550
RTALQKASSI AGLMITTEAM VTELPKKDDK SGGDMGDMGG GMGGMGGMGG

F
Length:551
Mass (Da):58,631
Last modified:October 14, 2008 - v1
Checksum:iE2664D8A15A7311A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001132 Genomic DNA. Translation: ACH82949.1.
RefSeqiWP_012536194.1. NC_011206.1.

Genome annotation databases

EnsemblBacteriaiACH82949; ACH82949; Lferr_0698.
KEGGiafe:Lferr_0698.

Similar proteinsi

Entry informationi

Entry nameiCH60_ACIF5
AccessioniPrimary (citable) accession number: B5EN19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families