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B5ELC6 (MRAY_ACIF5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Lferr_0388
OrganismAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993)) [Complete proteome] [HAMAP]
Taxonomic identifier380394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090583

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane339 – 35921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B5ELC6 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 564F7A075673FF43

FASTA36039,009
        10         20         30         40         50         60 
MLYALFMQLG SLYHGFYVFQ YLTLRGVLAT LTALVLSLFI GPFFIARLRR YKIGQMVRND 

        70         80         90        100        110        120 
GPETHLIKQG TPTMGGALIL LVVILTTLLW SDLGNPLVWV AVLTTLAFGA IGFVDDWRKL 

       130        140        150        160        170        180 
RRQNSKGLSA RAKYGLQSLV AFAAGGVLYA LASNPVETSL ILPFIPHVLI PMGAGFIVFS 

       190        200        210        220        230        240 
YFVIVGTSNA VNLTDGLDGL AIVPTVMVAG ALGVFAYVSG NAVFARYLDV PWVPGSGQML 

       250        260        270        280        290        300 
IFCGALVGAG LGFLWFNTYP ADVFMGDTGA LALGAALAIV AIVARQELVL FIMGGVFVVE 

       310        320        330        340        350        360 
TLSVIIQVVS FRLTGKRVFR MAPLHHHFEK KGWPEPRVAV RFWIITVILV LVGLSSLKIR

« Hide

References

[1]"Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Borole A.P.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 53993.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001132 Genomic DNA. Translation: ACH82642.1.
RefSeqYP_002218849.1. NC_011206.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB5ELC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6876339.
GenomeReviewsGene locus Lferr_0388 in contig CP001132_GR.
KEGGafe:Lferr_0388.
PATRIC20658296. VBIAciFer6930_0373.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIF5
AccessionPrimary (citable) accession number: B5ELC6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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