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B5ELA6 (F16PA_ACIF5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Gene names
Name:fbp
Ordered Locus Names:Lferr_0368
OrganismAcidithiobacillus ferrooxidans (strain ATCC 53993) (Leptospirillum ferrooxidans (ATCC 53993)) [Complete proteome] [HAMAP]
Taxonomic identifier380394 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855
PRO_0000364444

Regions

Region117 – 1204Substrate binding By similarity

Sites

Metal binding921Magnesium 1 By similarity
Metal binding1141Magnesium 1 By similarity
Metal binding1141Magnesium 2 By similarity
Metal binding1161Magnesium 1; via carbonyl oxygen By similarity
Metal binding1171Magnesium 2 By similarity
Metal binding2811Magnesium 2 By similarity
Binding site2091Substrate By similarity
Binding site2751Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B5ELA6 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: E757B7A9716587C1

FASTA33937,199
        10         20         30         40         50         60 
MHIGTTLSQF IIEETRLYPG ASGDFAGLLN DLTTSCKFIG AQVYRGALVG ALGSAGTDNV 

        70         80         90        100        110        120 
QGEVQKKLDI ISNEAILKSM DWTGHLAGMA SEEMDDPYPI PRNIPRGKYL LLFDPLDGSS 

       130        140        150        160        170        180 
NTDVGISVGT IFSILKAPVA GRDAELADFL QPGVEQVCAG YALYGSSNML VYSTGYGVNG 

       190        200        210        220        230        240 
FTLDPSIGEY ILTHNQMRIP EDTSEYAINM SNHRHWQKPV QRYIDELNQG TDGPRQRDFN 

       250        260        270        280        290        300 
MRWVGSMVAD VHRILCRGGI FLYPFDQRDP KKPGKLRLLY EANPMSYLVE QAGGAASTGT 

       310        320        330 
TRILDIVPQG LHQRIPVILG AKNEVERVVA YHQGSFVIP

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References

[1]"Complete sequence of Acidithiobacillus ferrooxidans ATCC 53993."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Borole A.P.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 53993.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001132 Genomic DNA. Translation: ACH82622.1.
RefSeqYP_002218829.1. NC_011206.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB5ELA6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6876319.
GenomeReviewsGene locus Lferr_0368 in contig CP001132_GR.
KEGGafe:Lferr_0368.
PATRIC20658256. VBIAciFer6930_0353.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG731261.
OMANEWAGHL.
ProtClustDBPRK09293.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. FBPase_class-1/SBPase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
KOK03841.
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFPIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF16PA_ACIF5
AccessionPrimary (citable) accession number: B5ELA6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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