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B5EJ44 (HEMH_GEOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:Gbem_0039
OrganismGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) [Complete proteome] [HAMAP]
Taxonomic identifier404380 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Ferrochelatase HAMAP MF_00323
PRO_1000116047

Sites

Metal binding1921Iron By similarity
Metal binding2711Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B5EJ44 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 47982A54C807C79E

FASTA31735,573
        10         20         30         40         50         60 
MSSKTALLLL QMGGPDSLDA VHPFLMNLFT DRDIIKIGPA FLQPFIARRI VNKRAPKVEE 

        70         80         90        100        110        120 
YYRQIGGKSP IRELTEAQGE GLQQLLGEDF RSFVAMRYSR PSTIDALAAI KRAGIERVIA 

       130        140        150        160        170        180 
LSLYPHYSKA TTGSSLNELK RVLKESGAKF EISYIDRFYN HPLYIKALSE KVVQGLASFP 

       190        200        210        220        230        240 
DRKDVEIVFS AHSLPQSFIE EGDPYLDHIQ ETVRLVMEQV GEGSHTLCFQ SKASRVKWLE 

       250        260        270        280        290        300 
PSTEATIEQM AKAGKKNLLM VPLSFVSDHI ETLYEIDIQY GEEAKALGIE RFVRSESLNS 

       310 
SPLFLECLAD LVKTAAK

« Hide

References

[1]"Complete sequence of Geobacter bemidjiensis BEM."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Lovley D., Richardson P.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bem / ATCC BAA-1014 / DSM 16622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001124 Genomic DNA. Translation: ACH37070.1.
RefSeqYP_002136866.1. NC_011146.1.

3D structure databases

ProteinModelPortalB5EJ44.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5EJ44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6782857.
GenomeReviewsGene locus Gbem_0039 in contig CP001124_GR.
KEGGgbm:Gbem_0039.
PATRIC21983735. VBIGeoBem56306_0039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALLQMGGP.
ProtClustDBCLSK790160.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_GEOBB
AccessionPrimary (citable) accession number: B5EJ44
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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