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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGBEM404380:GHFR-2970-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:Gbem_2916
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000008825 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000145594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_2916.

Structurei

3D structure databases

ProteinModelPortaliB5EIW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5EIW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKWTINDSS KIYNIDNWGA ELFSINKKGN VCVHPSPNSK YSIDLKVLVD
60 70 80 90 100
DLIKRKIKPP ILLRFMNILE GRIASISRVF KNAISDNNYP AKYQTFYPIK
110 120 130 140 150
VNQQRQVVEA IANFGKKYNI GLEVGSKPEL VAAISMSTGN NLPILCNGYK
160 170 180 190 200
DTEFIETVLF ATRVGYDITI VVEKLFELEK IVEVSKRTGI VPKLGIRVKL
210 220 230 240 250
SSKGIGKWST SGGDDAKFGL RISELIAAID MLKQNDMLDS VKLLHFHVGS
260 270 280 290 300
QITKIDKIKN ALIEGTRIYA EMRKLGVNLE FLDIGGGLGV DYDGSKSSYF
310 320 330 340 350
SSVNYSLEEY ANDVIYQVKN ICDDAGVPCP NIISESGRAT VAHYSVLVTD
360 370 380 390 400
VLNNNTQTLM PDFESILTEP EKLSPTVKKL VDIYKSIDKH SLREDYHDTI
410 420 430 440 450
QLIQESVSLF NLGYLNMAER ANAEWICSKI IRKINSIVEK MKPIPDELQN
460 470 480 490 500
FQLSLRQTYF ANFSLFQSIP DSWAIDQLFP IVPIQRLDEK PDVLTSIADI
510 520 530 540 550
TCDSDGEITS FVGENGRTKA LPLHKIKVDE QYYIGFFLIG AYQEILGDMH
560 570 580 590 600
NLFGDTNAVH ITFNKKTNYK IDTVISGDAT WESLKYVQYD SQEILKRVRN
610 620 630
NLEKDVSLQK VSIEESSHFL ELLDKTLQSY TYLGE
Length:635
Mass (Da):71,687
Last modified:October 14, 2008 - v1
Checksum:i0AF4EC3505D54F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH39919.1.
RefSeqiWP_012531344.1. NC_011146.1.
YP_002139715.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH39919; ACH39919; Gbem_2916.
KEGGigbm:Gbem_2916.
PATRICi21989500. VBIGeoBem56306_2863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH39919.1.
RefSeqiWP_012531344.1. NC_011146.1.
YP_002139715.1. NC_011146.1.

3D structure databases

ProteinModelPortaliB5EIW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi404380.Gbem_2916.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH39919; ACH39919; Gbem_2916.
KEGGigbm:Gbem_2916.
PATRICi21989500. VBIGeoBem56306_2863.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciGBEM404380:GHFR-2970-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bem / ATCC BAA-1014 / DSM 16622.

Entry informationi

Entry nameiSPEA_GEOBB
AccessioniPrimary (citable) accession number: B5EIW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: May 27, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.