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B5EIW4 (SPEA_GEOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Gbem_2916
OrganismGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) [Complete proteome] [HAMAP]
Taxonomic identifier404380 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity.

Catalytic activity

L-arginine = agmatine + CO2.

Cofactor

Magnesium By similarity.

Pyridoxal phosphate By similarity.

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Biosynthetic arginine decarboxylase
PRO_1000145594

Regions

Region282 – 29211Substrate-binding Potential

Amino acid modifications

Modified residue1001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B5EIW4 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 0AF4EC3505D54F1D

FASTA63571,687
        10         20         30         40         50         60 
MAKWTINDSS KIYNIDNWGA ELFSINKKGN VCVHPSPNSK YSIDLKVLVD DLIKRKIKPP 

        70         80         90        100        110        120 
ILLRFMNILE GRIASISRVF KNAISDNNYP AKYQTFYPIK VNQQRQVVEA IANFGKKYNI 

       130        140        150        160        170        180 
GLEVGSKPEL VAAISMSTGN NLPILCNGYK DTEFIETVLF ATRVGYDITI VVEKLFELEK 

       190        200        210        220        230        240 
IVEVSKRTGI VPKLGIRVKL SSKGIGKWST SGGDDAKFGL RISELIAAID MLKQNDMLDS 

       250        260        270        280        290        300 
VKLLHFHVGS QITKIDKIKN ALIEGTRIYA EMRKLGVNLE FLDIGGGLGV DYDGSKSSYF 

       310        320        330        340        350        360 
SSVNYSLEEY ANDVIYQVKN ICDDAGVPCP NIISESGRAT VAHYSVLVTD VLNNNTQTLM 

       370        380        390        400        410        420 
PDFESILTEP EKLSPTVKKL VDIYKSIDKH SLREDYHDTI QLIQESVSLF NLGYLNMAER 

       430        440        450        460        470        480 
ANAEWICSKI IRKINSIVEK MKPIPDELQN FQLSLRQTYF ANFSLFQSIP DSWAIDQLFP 

       490        500        510        520        530        540 
IVPIQRLDEK PDVLTSIADI TCDSDGEITS FVGENGRTKA LPLHKIKVDE QYYIGFFLIG 

       550        560        570        580        590        600 
AYQEILGDMH NLFGDTNAVH ITFNKKTNYK IDTVISGDAT WESLKYVQYD SQEILKRVRN 

       610        620        630 
NLEKDVSLQK VSIEESSHFL ELLDKTLQSY TYLGE 

« Hide

References

[1]"Complete sequence of Geobacter bemidjiensis BEM."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Lovley D., Richardson P.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bem / ATCC BAA-1014 / DSM 16622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001124 Genomic DNA. Translation: ACH39919.1.
RefSeqYP_002139715.1. NC_011146.1.

3D structure databases

ProteinModelPortalB5EIW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING404380.Gbem_2916.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH39919; ACH39919; Gbem_2916.
GeneID6779769.
KEGGgbm:Gbem_2916.
PATRIC21989500. VBIGeoBem56306_2863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycGBEM404380:GHFR-2970-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_GEOBB
AccessionPrimary (citable) accession number: B5EIW4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways