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Protein

6-phosphofructokinase

Gene

pfk-3

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.SAAS annotation

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.SAAS annotation

Cofactori

Mg2+SAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk-1), ATP-dependent 6-phosphofructokinase (pfk-2), 6-phosphofructokinase (pfk-3)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphofructokinaseSAAS annotation (EC:2.7.1.11SAAS annotation)
Gene namesi
Name:pfk-3Imported
Ordered Locus Names:Gbem_2820Imported
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)Imported
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000008825 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Subunit structurei

Homotetramer.SAAS annotation

Protein-protein interaction databases

STRINGi404380.Gbem_2820.

Structurei

3D structure databases

ProteinModelPortaliB5EIC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 332PFKInterPro annotationAdd BLAST325

Sequence similaritiesi

Belongs to the phosphofructokinase type A (PFKA) family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107SXZ. Bacteria.
COG0205. LUCA.
HOGENOMiHOG000248869.
KOiK00850.
OMAiRHIPIST.
OrthoDBiPOG091H01AC.

Family and domain databases

InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EIC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRQKTVGV LTGGGDVPGL NPALKTLVTR AVENGYRVLG IRRGWGGLLA
60 70 80 90 100
YNRDDPHSGE STLMPLDRHS VRTVDRSGGT FLHTSRTNPG KVATADVPEF
110 120 130 140 150
LRGADFDPLN PGHHDFTQHV LANLEHLGVD SLIAIGGDDT LSYAERLFRE
160 170 180 190 200
GVPVVAIPKT MDNDVFGTDY CIGFSTAVTR SVNFIHNLRT SAGSHERIAV
210 220 230 240 250
VELFGRNSGE TSLISAYLAG VDRALISEVP FDVERLALLL QEDKRSNRSN
260 270 280 290 300
YAMVTVSEGA SMIGGQTVEY GQEDAYGHKK LGGIGVVVSE AVKGLTGSHI
310 320 330 340 350
IYQQLSYLMR SGAPDSLDLM VAYNYANMTM DLISEGMSGR MVSLQGGTYR
360 370 380 390
HIPISTIMQG EKRVDVAELY DLAEYRPKVR HVLGKPMFLY
Length:390
Mass (Da):42,448
Last modified:October 14, 2008 - v1
Checksum:i03C2596C0A648267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH39824.1.
RefSeqiWP_012531250.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH39824; ACH39824; Gbem_2820.
KEGGigbm:Gbem_2820.
PATRICi21989314. VBIGeoBem56306_2771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH39824.1.
RefSeqiWP_012531250.1. NC_011146.1.

3D structure databases

ProteinModelPortaliB5EIC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi404380.Gbem_2820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH39824; ACH39824; Gbem_2820.
KEGGigbm:Gbem_2820.
PATRICi21989314. VBIGeoBem56306_2771.

Phylogenomic databases

eggNOGiENOG4107SXZ. Bacteria.
COG0205. LUCA.
HOGENOMiHOG000248869.
KOiK00850.
OMAiRHIPIST.
OrthoDBiPOG091H01AC.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.

Family and domain databases

InterProiIPR022953. ATP_PFK.
IPR012003. ATP_PFK_prok-type.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB5EIC2_GEOBB
AccessioniPrimary (citable) accession number: B5EIC2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.