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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi483MagnesiumUniRule annotation1
Metal bindingi489MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Gbem_1308
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000008825 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003818981 – 696Polyribonucleotide nucleotidyltransferaseAdd BLAST696

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_1308.

Structurei

3D structure databases

ProteinModelPortaliB5EI63.
SMRiB5EI63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini550 – 609KHUniRule annotationAdd BLAST60
Domaini619 – 687S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218327.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EI63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHTVQAECC GKTITIETGK IAKQASGAVM IKSGDTMVLV TAVAMKSAKE
60 70 80 90 100
GQGFFPLTVN YQEKAYAGGR IPGSFFKREG RPSDNETLTC RLIDRPIRPL
110 120 130 140 150
FPENFLNDTQ IMATVVSADK DNDPGILSMI GASAALMVSD VPFAGPIAGV
160 170 180 190 200
KVGRVDGQFI ANPTAEQEEK SDLEIVIAAS QDAILMVEGS ACEVSEDDLL
210 220 230 240 250
EAIFFGHKAV QPVLAAQLEL AKKVGTSKRE IPAPVVNEAL KARVSALAKE
260 270 280 290 300
GMKQAVRIKT KVERHLAIDA IADETVAALS AEFEGSEKEI KGFIEDLEYD
310 320 330 340 350
LVREHIIKDG QRIDGRDTKT IRAISTEVSL LPRAHGSALF TRGETQSIVA
360 370 380 390 400
ATLGTSVDEQ RIDSLYGDSR KKFMLHYNFP PYSVGETSFR LAPGRREIGH
410 420 430 440 450
GMLAERALQQ VLPKHDDFPY TIRIVSDITE SNGSSSMATV CGGSLSMMDA
460 470 480 490 500
GIPIKAPVAG IAMGLIKEGD DFAILSDILG DEDHLGDMDF KVAGTAEGVT
510 520 530 540 550
ALQMDIKIGG VTREIMSAAL AQAKAGRIHI LGEMAKTIGA SRGDLSAFAP
560 570 580 590 600
RITTIWVKVD KIRDVIGSGG KNIRSVTEAT GVSIDIDDTG KINIASTNKE
610 620 630 640 650
ACDLAIKMIR NLTAEAEEGK LYMGTVKKIM EFGAFVEIFP GTDGLVHVSE
660 670 680 690
LDTERVKNVS DILKEGDKVL VKCIGIDKQG KIKLSRKEAL GLTFTE
Length:696
Mass (Da):74,701
Last modified:October 14, 2008 - v1
Checksum:i14A55B42966E28D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH38327.1.
RefSeqiWP_012529738.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH38327; ACH38327; Gbem_1308.
KEGGigbm:Gbem_1308.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPNP_GEOBB
AccessioniPrimary (citable) accession number: B5EI63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 14, 2008
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families