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B5EGN2 (GMHA_GEOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoheptose isomerase
EC=5.3.1.28
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene names
Name:gmhA
Ordered Locus Names:Gbem_2507
OrganismGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) [Complete proteome] [HAMAP]
Taxonomic identifier404380 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Catalytic activity

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067

Subunit structure

Homotetramer By similarity. HAMAP MF_00067

Subcellular location

Cytoplasm By similarity HAMAP MF_00067.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Contains 1 SIS domain.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide core region biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionD-sedoheptulose 7-phosphate isomerase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sugar binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 192192Phosphoheptose isomerase HAMAP MF_00067
PRO_1000092274

Regions

Domain34 – 192159SIS
Region49 – 513Substrate binding By similarity
Region91 – 922Substrate binding By similarity
Region117 – 1193Substrate binding By similarity

Sites

Metal binding581Zinc By similarity
Metal binding621Zinc By similarity
Metal binding1691Zinc By similarity
Metal binding1771Zinc By similarity
Binding site621Substrate By similarity
Binding site1221Substrate By similarity
Binding site1691Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B5EGN2 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 445C41810BE93DBF

FASTA19220,393
        10         20         30         40         50         60 
MLVEIKAQLK AHCEVMTALQ GELSPAIESA VSLVVDAYKA GNKLLVMGNG GSAADAQHFV 

        70         80         90        100        110        120 
AEMVGRFKLE RRALPAIALH TDTSILTAIG NDYGFDRIFS RQVEAHAAAG DVVVGISTSG 

       130        140        150        160        170        180 
NSPNVQLALE LAREKGCRTI ALLGKDGGSI KSVAELPLIV PSNDTPRIQE GHITIIHIIC 

       190 
DLVERELFVK GK

« Hide

References

[1]"Complete sequence of Geobacter bemidjiensis BEM."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Lovley D., Richardson P.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bem / ATCC BAA-1014 / DSM 16622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001124 Genomic DNA. Translation: ACH39515.1.
RefSeqYP_002139311.1. NC_011146.1.

3D structure databases

ProteinModelPortalB5EGN2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5EGN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6782504.
GenomeReviewsGene locus Gbem_2507 in contig CP001124_GR.
KEGGgbm:Gbem_2507.
PATRIC21988696. VBIGeoBem56306_2465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG671955.
OMAHITIIHI.
ProtClustDBPRK13937.

Family and domain databases

HAMAPMF_00067. GmhA.
[Tree]
InterProIPR004515. Phosphoheptose_Isoase_subgr.
IPR020620. Phosphoheptose_isomerase.
IPR001347. SIS.
[Graphical view]
KOK03271.
PfamPF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR00441. GmhA. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGMHA_GEOBB
AccessionPrimary (citable) accession number: B5EGN2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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