B5EEX1 (B5EEX1_GEOBB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Gbem_0844

Organism

Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) [Complete proteome] [HAMAP]

Taxonomic identifier

404380 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5EEX1 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 586F9DB8C959BAC8	FASTA	380	41,497
	10 20 30 40 50 60 MQEKPKSVMI VAGEASGEMY GASIATEIRA LAPETRFFGM GGGNMRKAGV ETLVDADTMA 70 80 90 100 110 120 VMGLVEVVAH LPVIVNGFNT LKNKLRSDLP DLLILIDYPD FNLRLAKVAK KAGVKVLYFI 130 140 150 160 170 180 SPQVWAWRSG RVKGIGRVVD MMAVLFPFEV PFYQNAGVPV TFVGHPLLDL VRPTMKRDEA 190 200 210 220 230 240 LSSLGLDPQR RCVGLFPGSR KSEIGKLLGI ILESAEILKK RMPELQFVLP LASSLRREDL 250 260 270 280 290 300 DPYLSGSKVE VRVVSGRNHD VMTACDAAVC ASGTVVMEMA LVGTPHLIIY KMSTFTYEVG 310 320 330 340 350 360 KRVINVPHIG ISNIVAEKRM VRELVQHEAE PVAIADEVDA LLNDAAYATE MREGFAAMRV 370 380 KLGSGGALGR VARLAMEMMR

References

[1]

"Complete sequence of Geobacter bemidjiensis BEM." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Lykidis A., Lovley D., Richardson P. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bem / ATCC BAA-1014 / DSM 16622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001124 Genomic DNA. Translation: ACH37867.1.
RefSeq	YP_002137663.1. NC_011146.1.
3D structure databases
ProteinModelPortal	B5EEX1.
ModBase	Search...
Protein-protein interaction databases
STRING	B5EEX1.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6783682.
GenomeReviews	Gene locus Gbem_0844 in contig CP001124_GR.
KEGG	gbm:Gbem_0844.
PATRIC	21985381. VBIGeoBem56306_0843.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	PRK00025.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5EEX1_GEOBB

Accession

Primary (citable) accession number: B5EEX1

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)