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B5EE39

- SYL_GEOBB

UniProt

B5EE39 - SYL_GEOBB

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Protein
Leucine--tRNA ligase
Gene
leuS, Gbem_0751
Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBEM404380:GHFR-756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Gbem_0751
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000008825: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligaseUniRule annotation
PRO_1000091321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_0751.

Structurei

3D structure databases

ProteinModelPortaliB5EE39.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5EE39-1 [UniParc]FASTAAdd to Basket

« Hide

MEEKYVPSAV EEKWQGYWAE HKSFKANEDP SRKKYYLLEM FPYPSGKIHM    50
GHVRNYSIGD VIARFKRMQG YNVLHPMGWD AFGMPAENAA IQHKSHPAKW 100
TYENIAYMRG QLKTLGLSYD WDRELATCDL DYYKWEQRIF LEMYKKGLAY 150
KKSSAVNWCP KCETVLANEQ VEDGCCWRCD SPVQQKELEQ WSFRITNYAQ 200
ELLDDTYKLT GWPERVLTMQ RNWIGRSTGC EIDFPLESGL GKIKVFTTRQ 250
DTLFGATFMS LAAEHPMALD LAGDAQKAEV AAFIDKVKKT DRIKRGAEDL 300
EKEGVFTGSY CINPVTNTKM PIYLANFVLM DYGTGAVMAV PTHDQRDFEF 350
AKKYNLPLKV VIQPEGETLD PATMTEAYTA EGIMVNSGRF DGMGNADAKE 400
AIADFLEKEG IGKKTVNFRL RDWGISRQRY WGNPIPVINC DLCGVVAVPE 450
ADLPVVLPMD AEFTGEGGNP LARVDSFTTC TCPQCGETAR RETDTMDTFV 500
QSSWYFLRYC SPKFSAGPLD REKVEAWMPV DQYIGGIEHA VLHLLYARFF 550
TKVLRDLGYC NVDEPFSNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG 600
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWRLVY DVLPVIGDAG 650
AVNPGELGAE AKKLRRAVHK TIKKVSEDVE ERFHFNTAIA AVMELVNAIQ 700
AFSAKDAPEN VAVVREAVES VVRLLAPFVP NFAEELWFQL GHASVLEAAG 750
WPGYDAAAVV DEEVTVVIQV NGKLRSKLTV APDAKEEEVR AQALADDKIK 800
PYLEGKDVKK VVYVPGKLVS IVVA 824
Length:824
Mass (Da):92,622
Last modified:October 14, 2008 - v1
Checksum:i8D2FC08F5B069D1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001124 Genomic DNA. Translation: ACH37777.1.
RefSeqiWP_012529184.1. NC_011146.1.
YP_002137573.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH37777; ACH37777; Gbem_0751.
GeneIDi6783584.
KEGGigbm:Gbem_0751.
PATRICi21985175. VBIGeoBem56306_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001124 Genomic DNA. Translation: ACH37777.1 .
RefSeqi WP_012529184.1. NC_011146.1.
YP_002137573.1. NC_011146.1.

3D structure databases

ProteinModelPortali B5EE39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404380.Gbem_0751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH37777 ; ACH37777 ; Gbem_0751 .
GeneIDi 6783584.
KEGGi gbm:Gbem_0751.
PATRICi 21985175. VBIGeoBem56306_0746.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GBEM404380:GHFR-756-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bem / ATCC BAA-1014 / DSM 16622.

Entry informationi

Entry nameiSYL_GEOBB
AccessioniPrimary (citable) accession number: B5EE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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