Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B5EE39

- SYL_GEOBB

UniProt

B5EE39 - SYL_GEOBB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBEM404380:GHFR-756-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Gbem_0751
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000008825: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligasePRO_1000091321Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_0751.

Structurei

3D structure databases

ProteinModelPortaliB5EE39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5EE39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKYVPSAV EEKWQGYWAE HKSFKANEDP SRKKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VIARFKRMQG YNVLHPMGWD AFGMPAENAA IQHKSHPAKW
110 120 130 140 150
TYENIAYMRG QLKTLGLSYD WDRELATCDL DYYKWEQRIF LEMYKKGLAY
160 170 180 190 200
KKSSAVNWCP KCETVLANEQ VEDGCCWRCD SPVQQKELEQ WSFRITNYAQ
210 220 230 240 250
ELLDDTYKLT GWPERVLTMQ RNWIGRSTGC EIDFPLESGL GKIKVFTTRQ
260 270 280 290 300
DTLFGATFMS LAAEHPMALD LAGDAQKAEV AAFIDKVKKT DRIKRGAEDL
310 320 330 340 350
EKEGVFTGSY CINPVTNTKM PIYLANFVLM DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
AKKYNLPLKV VIQPEGETLD PATMTEAYTA EGIMVNSGRF DGMGNADAKE
410 420 430 440 450
AIADFLEKEG IGKKTVNFRL RDWGISRQRY WGNPIPVINC DLCGVVAVPE
460 470 480 490 500
ADLPVVLPMD AEFTGEGGNP LARVDSFTTC TCPQCGETAR RETDTMDTFV
510 520 530 540 550
QSSWYFLRYC SPKFSAGPLD REKVEAWMPV DQYIGGIEHA VLHLLYARFF
560 570 580 590 600
TKVLRDLGYC NVDEPFSNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWRLVY DVLPVIGDAG
660 670 680 690 700
AVNPGELGAE AKKLRRAVHK TIKKVSEDVE ERFHFNTAIA AVMELVNAIQ
710 720 730 740 750
AFSAKDAPEN VAVVREAVES VVRLLAPFVP NFAEELWFQL GHASVLEAAG
760 770 780 790 800
WPGYDAAAVV DEEVTVVIQV NGKLRSKLTV APDAKEEEVR AQALADDKIK
810 820
PYLEGKDVKK VVYVPGKLVS IVVA
Length:824
Mass (Da):92,622
Last modified:October 14, 2008 - v1
Checksum:i8D2FC08F5B069D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH37777.1.
RefSeqiWP_012529184.1. NC_011146.1.
YP_002137573.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH37777; ACH37777; Gbem_0751.
GeneIDi6783584.
KEGGigbm:Gbem_0751.
PATRICi21985175. VBIGeoBem56306_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH37777.1 .
RefSeqi WP_012529184.1. NC_011146.1.
YP_002137573.1. NC_011146.1.

3D structure databases

ProteinModelPortali B5EE39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404380.Gbem_0751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH37777 ; ACH37777 ; Gbem_0751 .
GeneIDi 6783584.
KEGGi gbm:Gbem_0751.
PATRICi 21985175. VBIGeoBem56306_0746.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GBEM404380:GHFR-756-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bem / ATCC BAA-1014 / DSM 16622.

Entry informationi

Entry nameiSYL_GEOBB
AccessioniPrimary (citable) accession number: B5EE39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3