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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBEM404380:G1GCH-755-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Gbem_0751
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000008825 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913211 – 824Leucine--tRNA ligaseAdd BLAST824

Proteomic databases

PRIDEiB5EE39

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_0751

Structurei

3D structure databases

ProteinModelPortaliB5EE39
SMRiB5EE39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B5EE39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKYVPSAV EEKWQGYWAE HKSFKANEDP SRKKYYLLEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VIARFKRMQG YNVLHPMGWD AFGMPAENAA IQHKSHPAKW
110 120 130 140 150
TYENIAYMRG QLKTLGLSYD WDRELATCDL DYYKWEQRIF LEMYKKGLAY
160 170 180 190 200
KKSSAVNWCP KCETVLANEQ VEDGCCWRCD SPVQQKELEQ WSFRITNYAQ
210 220 230 240 250
ELLDDTYKLT GWPERVLTMQ RNWIGRSTGC EIDFPLESGL GKIKVFTTRQ
260 270 280 290 300
DTLFGATFMS LAAEHPMALD LAGDAQKAEV AAFIDKVKKT DRIKRGAEDL
310 320 330 340 350
EKEGVFTGSY CINPVTNTKM PIYLANFVLM DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
AKKYNLPLKV VIQPEGETLD PATMTEAYTA EGIMVNSGRF DGMGNADAKE
410 420 430 440 450
AIADFLEKEG IGKKTVNFRL RDWGISRQRY WGNPIPVINC DLCGVVAVPE
460 470 480 490 500
ADLPVVLPMD AEFTGEGGNP LARVDSFTTC TCPQCGETAR RETDTMDTFV
510 520 530 540 550
QSSWYFLRYC SPKFSAGPLD REKVEAWMPV DQYIGGIEHA VLHLLYARFF
560 570 580 590 600
TKVLRDLGYC NVDEPFSNLL TQGMVIKDGA KMSKSKGNVV DPNALIERYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWRLVY DVLPVIGDAG
660 670 680 690 700
AVNPGELGAE AKKLRRAVHK TIKKVSEDVE ERFHFNTAIA AVMELVNAIQ
710 720 730 740 750
AFSAKDAPEN VAVVREAVES VVRLLAPFVP NFAEELWFQL GHASVLEAAG
760 770 780 790 800
WPGYDAAAVV DEEVTVVIQV NGKLRSKLTV APDAKEEEVR AQALADDKIK
810 820
PYLEGKDVKK VVYVPGKLVS IVVA
Length:824
Mass (Da):92,622
Last modified:October 14, 2008 - v1
Checksum:i8D2FC08F5B069D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA Translation: ACH37777.1
RefSeqiWP_012529184.1, NC_011146.1

Genome annotation databases

EnsemblBacteriaiACH37777; ACH37777; Gbem_0751
KEGGigbm:Gbem_0751

Similar proteinsi

Entry informationi

Entry nameiSYL_GEOBB
AccessioniPrimary (citable) accession number: B5EE39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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