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B5EDQ6

- GCH4_GEOBB

UniProt

B5EDQ6 - GCH4_GEOBB

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Gbem_3692
Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGBEM404380:GHFR-3761-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Gbem_3692
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000008825: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267GTP cyclohydrolase FolE2UniRule annotationPRO_1000185153Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404380.Gbem_3692.

Structurei

3D structure databases

ProteinModelPortaliB5EDQ6.
SMRiB5EDQ6. Positions 22-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EDQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MIKEYLKKPS LSDVQLTRDT RNIPIGKVGV KDISYPIVVM DKNKSFQNTI    50
ARINMYVDLP HHFKGTHMSR FVEILNEYRE EIALDKLELI LSTMKEKLGA 100
SNAHLEMEFP YFVEKTAPVS RAKSLMEYTC TFSASLSDRF DFVLGIKVPV 150
TSLCPCSKEL SSYGAHNQRS IMTVQVRYSE FIWIEDLIEI IEQCGSSPVY 200
SLLKREDEKF VTERAYENPR FVEDMVREAT VRLLSMQNVT WFSVEAENFE 250
SIHKHSAYAA IERSRES 267
Length:267
Mass (Da):30,890
Last modified:October 14, 2008 - v1
Checksum:i5D17AC8F29B962FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001124 Genomic DNA. Translation: ACH40684.1.
RefSeqiWP_012532122.1. NC_011146.1.
YP_002140480.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH40684; ACH40684; Gbem_3692.
GeneIDi6780556.
KEGGigbm:Gbem_3692.
PATRICi21991002. VBIGeoBem56306_3602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001124 Genomic DNA. Translation: ACH40684.1 .
RefSeqi WP_012532122.1. NC_011146.1.
YP_002140480.1. NC_011146.1.

3D structure databases

ProteinModelPortali B5EDQ6.
SMRi B5EDQ6. Positions 22-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404380.Gbem_3692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH40684 ; ACH40684 ; Gbem_3692 .
GeneIDi 6780556.
KEGGi gbm:Gbem_3692.
PATRICi 21991002. VBIGeoBem56306_3602.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci GBEM404380:GHFR-3761-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bem / ATCC BAA-1014 / DSM 16622.

Entry informationi

Entry nameiGCH4_GEOBB
AccessioniPrimary (citable) accession number: B5EDQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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