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B5EDQ6

- GCH4_GEOBB

UniProt

B5EDQ6 - GCH4_GEOBB

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei154 – 1541May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciGBEM404380:GHFR-3761-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Gbem_3692
    OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
    Taxonomic identifieri404380 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000008825: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267GTP cyclohydrolase FolE2PRO_1000185153Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi404380.Gbem_3692.

    Structurei

    3D structure databases

    ProteinModelPortaliB5EDQ6.
    SMRiB5EDQ6. Positions 22-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5EDQ6-1 [UniParc]FASTAAdd to Basket

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    MIKEYLKKPS LSDVQLTRDT RNIPIGKVGV KDISYPIVVM DKNKSFQNTI    50
    ARINMYVDLP HHFKGTHMSR FVEILNEYRE EIALDKLELI LSTMKEKLGA 100
    SNAHLEMEFP YFVEKTAPVS RAKSLMEYTC TFSASLSDRF DFVLGIKVPV 150
    TSLCPCSKEL SSYGAHNQRS IMTVQVRYSE FIWIEDLIEI IEQCGSSPVY 200
    SLLKREDEKF VTERAYENPR FVEDMVREAT VRLLSMQNVT WFSVEAENFE 250
    SIHKHSAYAA IERSRES 267
    Length:267
    Mass (Da):30,890
    Last modified:October 14, 2008 - v1
    Checksum:i5D17AC8F29B962FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001124 Genomic DNA. Translation: ACH40684.1.
    RefSeqiWP_012532122.1. NC_011146.1.
    YP_002140480.1. NC_011146.1.

    Genome annotation databases

    EnsemblBacteriaiACH40684; ACH40684; Gbem_3692.
    GeneIDi6780556.
    KEGGigbm:Gbem_3692.
    PATRICi21991002. VBIGeoBem56306_3602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001124 Genomic DNA. Translation: ACH40684.1 .
    RefSeqi WP_012532122.1. NC_011146.1.
    YP_002140480.1. NC_011146.1.

    3D structure databases

    ProteinModelPortali B5EDQ6.
    SMRi B5EDQ6. Positions 22-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 404380.Gbem_3692.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH40684 ; ACH40684 ; Gbem_3692 .
    GeneIDi 6780556.
    KEGGi gbm:Gbem_3692.
    PATRICi 21991002. VBIGeoBem56306_3602.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci GBEM404380:GHFR-3761-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bem / ATCC BAA-1014 / DSM 16622.

    Entry informationi

    Entry nameiGCH4_GEOBB
    AccessioniPrimary (citable) accession number: B5EDQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3