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B5EBF9

- PUR9_GEOBB

UniProt

B5EBF9 - PUR9_GEOBB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciGBEM404380:GHFR-3521-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Gbem_3458
    OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
    Taxonomic identifieri404380 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000008825: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Bifunctional purine biosynthesis protein PurHPRO_1000096065Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi404380.Gbem_3458.

    Structurei

    3D structure databases

    ProteinModelPortaliB5EBF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5EBF9-1 [UniParc]FASTAAdd to Basket

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    MAKIGRALIS VSEKTGVVEF SRALAGYGVE ILSTGGTAKL LREAGIAVKD    50
    VSEFTGFPEM LDGRVKTLHP KVHGGILGMR ENPAHVAKMQ EHGIEPIDMV 100
    VVNLYPFEAT VAKEDCTMED AIENIDIGGP TMLRSAAKNN RDVTVVVDHA 150
    DYAVVLDEMK NSGGSVSRET NFRLAVKVYQ HTAAYDGAIS NWLGARTGEG 200
    VAPFPDTLTM QYKLAQGMRY GENPHQSGAF YVEKGSRESS ISTARQIQGK 250
    ELSYNNIGDT DAALECVKQF TEPACVIVKH ANPCGVALGA NIMEAYDKAY 300
    KTDPESAFGG IIAFNRELDE STARAIVERQ FVEVIIAPKV TEAASEIVAA 350
    KKNVRLMECG FWPENPAPRF DYKRVNGGML VQDADLELFT ELKVVTKRAP 400
    TDKEMEDLLF TWRVAKFVKS NAIVYGRDNS TVGVGAGQMS RVNSARIAAI 450
    KAEHAGIPVQ GAVMASDAFF PFRDGLDNAA SVGVTAVIQP GGSMRDAEVI 500
    AAADEHGIAM VFTSMRHFRH 520
    Length:520
    Mass (Da):56,257
    Last modified:October 14, 2008 - v1
    Checksum:i73B466BAC5D3FB55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001124 Genomic DNA. Translation: ACH40451.1.
    RefSeqiWP_012531884.1. NC_011146.1.
    YP_002140247.1. NC_011146.1.

    Genome annotation databases

    EnsemblBacteriaiACH40451; ACH40451; Gbem_3458.
    GeneIDi6780320.
    KEGGigbm:Gbem_3458.
    PATRICi21990556. VBIGeoBem56306_3381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001124 Genomic DNA. Translation: ACH40451.1 .
    RefSeqi WP_012531884.1. NC_011146.1.
    YP_002140247.1. NC_011146.1.

    3D structure databases

    ProteinModelPortali B5EBF9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 404380.Gbem_3458.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH40451 ; ACH40451 ; Gbem_3458 .
    GeneIDi 6780320.
    KEGGi gbm:Gbem_3458.
    PATRICi 21990556. VBIGeoBem56306_3381.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci GBEM404380:GHFR-3521-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bem / ATCC BAA-1014 / DSM 16622.

    Entry informationi

    Entry nameiPUR9_GEOBB
    AccessioniPrimary (citable) accession number: B5EBF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3