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B5EAW7

- GCSPA_GEOBB

UniProt

B5EAW7 - GCSPA_GEOBB

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciGBEM404380:GHFR-399-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Gbem_0397
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000008825: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000132481Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi404380.Gbem_0397.

Structurei

3D structure databases

ProteinModelPortaliB5EAW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiLPMHASE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B5EAW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYCPNTPDE IREMLAVIGA GSIEELFAPI PAELRAKSFD LPPGMSEFEL
60 70 80 90 100
MRIMREKAAA GGAEIVPFIG GGIYDHIIPA AVDHLSSRAE FYTAYTPYQP
110 120 130 140 150
ECSQGTLQAL FEYQSVICRL TGMEASNASL YDGGTAVAEA ALMSLRITER
160 170 180 190 200
NRVVLDASIN PLHREIVTGY LHGLSAEAVE VAPDGCGSDL KRLIDSIDEE
210 220 230 240 250
TAAVIVQNPN FFGSVQDFSE LAVKAHEKGA LLIISGYPIA LGLVASPGEM
260 270 280 290 300
GADIAVGDGQ SLGNPLSFGG PYFGFIATRK RFIRNLPGRI VGETIDNQGR
310 320 330 340 350
RGYVLTLQAR EQHIKRHKAT SNICSNQSLC ALRGLIFCAS LGRKGFEELA
360 370 380 390 400
VLNYDKAQYA KSRLTGVKGV SVMNAGTTFN EFTLSLPKDA APVVEKLLAC
410 420 430 440
GVAAGVPLVQ YYPGMDNALT VTVTEKRSKA EIDRLAALLE EALCS
Length:445
Mass (Da):47,702
Last modified:October 14, 2008 - v1
Checksum:iDD7E0CC389BD4EFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH37426.1.
RefSeqiYP_002137222.1. NC_011146.1.

Genome annotation databases

EnsemblBacteriaiACH37426; ACH37426; Gbem_0397.
GeneIDi6783223.
KEGGigbm:Gbem_0397.
PATRICi21984457. VBIGeoBem56306_0393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA. Translation: ACH37426.1 .
RefSeqi YP_002137222.1. NC_011146.1.

3D structure databases

ProteinModelPortali B5EAW7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404380.Gbem_0397.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH37426 ; ACH37426 ; Gbem_0397 .
GeneIDi 6783223.
KEGGi gbm:Gbem_0397.
PATRICi 21984457. VBIGeoBem56306_0393.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi LPMHASE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci GBEM404380:GHFR-399-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bem / ATCC BAA-1014 / DSM 16622.

Entry informationi

Entry nameiGCSPA_GEOBB
AccessioniPrimary (citable) accession number: B5EAW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3