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B5EAW7 (GCSPA_GEOBB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Gbem_0397
OrganismGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622) [Complete proteome] [HAMAP]
Taxonomic identifier404380 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132481

Sequences

Sequence LengthMass (Da)Tools
B5EAW7 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: DD7E0CC389BD4EFF

FASTA44547,702
        10         20         30         40         50         60 
MGYCPNTPDE IREMLAVIGA GSIEELFAPI PAELRAKSFD LPPGMSEFEL MRIMREKAAA 

        70         80         90        100        110        120 
GGAEIVPFIG GGIYDHIIPA AVDHLSSRAE FYTAYTPYQP ECSQGTLQAL FEYQSVICRL 

       130        140        150        160        170        180 
TGMEASNASL YDGGTAVAEA ALMSLRITER NRVVLDASIN PLHREIVTGY LHGLSAEAVE 

       190        200        210        220        230        240 
VAPDGCGSDL KRLIDSIDEE TAAVIVQNPN FFGSVQDFSE LAVKAHEKGA LLIISGYPIA 

       250        260        270        280        290        300 
LGLVASPGEM GADIAVGDGQ SLGNPLSFGG PYFGFIATRK RFIRNLPGRI VGETIDNQGR 

       310        320        330        340        350        360 
RGYVLTLQAR EQHIKRHKAT SNICSNQSLC ALRGLIFCAS LGRKGFEELA VLNYDKAQYA 

       370        380        390        400        410        420 
KSRLTGVKGV SVMNAGTTFN EFTLSLPKDA APVVEKLLAC GVAAGVPLVQ YYPGMDNALT 

       430        440 
VTVTEKRSKA EIDRLAALLE EALCS 

« Hide

References

[1]"Complete sequence of Geobacter bemidjiensis BEM."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Lovley D., Richardson P.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bem / ATCC BAA-1014 / DSM 16622.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001124 Genomic DNA. Translation: ACH37426.1.
RefSeqYP_002137222.1. NC_011146.1.

3D structure databases

ProteinModelPortalB5EAW7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING404380.Gbem_0397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH37426; ACH37426; Gbem_0397.
GeneID6783223.
KEGGgbm:Gbem_0397.
PATRIC21984457. VBIGeoBem56306_0393.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMALPMHASE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycGBEM404380:GHFR-399-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEOBB
AccessionPrimary (citable) accession number: B5EAW7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families