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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciGBEM404380:G1GCH-401-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Gbem_0397
OrganismiGeobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
Taxonomic identifieri404380 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000008825 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324811 – 445Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST445

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi404380.Gbem_0397

Structurei

3D structure databases

ProteinModelPortaliB5EAW7
SMRiB5EAW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B5EAW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYCPNTPDE IREMLAVIGA GSIEELFAPI PAELRAKSFD LPPGMSEFEL
60 70 80 90 100
MRIMREKAAA GGAEIVPFIG GGIYDHIIPA AVDHLSSRAE FYTAYTPYQP
110 120 130 140 150
ECSQGTLQAL FEYQSVICRL TGMEASNASL YDGGTAVAEA ALMSLRITER
160 170 180 190 200
NRVVLDASIN PLHREIVTGY LHGLSAEAVE VAPDGCGSDL KRLIDSIDEE
210 220 230 240 250
TAAVIVQNPN FFGSVQDFSE LAVKAHEKGA LLIISGYPIA LGLVASPGEM
260 270 280 290 300
GADIAVGDGQ SLGNPLSFGG PYFGFIATRK RFIRNLPGRI VGETIDNQGR
310 320 330 340 350
RGYVLTLQAR EQHIKRHKAT SNICSNQSLC ALRGLIFCAS LGRKGFEELA
360 370 380 390 400
VLNYDKAQYA KSRLTGVKGV SVMNAGTTFN EFTLSLPKDA APVVEKLLAC
410 420 430 440
GVAAGVPLVQ YYPGMDNALT VTVTEKRSKA EIDRLAALLE EALCS
Length:445
Mass (Da):47,702
Last modified:October 14, 2008 - v1
Checksum:iDD7E0CC389BD4EFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001124 Genomic DNA Translation: ACH37426.1
RefSeqiWP_012528834.1, NC_011146.1

Genome annotation databases

EnsemblBacteriaiACH37426; ACH37426; Gbem_0397
KEGGigbm:Gbem_0397

Similar proteinsi

Entry informationi

Entry nameiGCSPA_GEOBB
AccessioniPrimary (citable) accession number: B5EAW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health