B5E747 (B5E747_STRP4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Ordered Locus Names:

SPG_1606

Organism

Streptococcus pneumoniae serotype 19F (strain G54) [Complete proteome] [HAMAP] EMBL ACF54826.1

Taxonomic identifier

512566 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5E747 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 573CC7A2595C9EED	FASTA	343	38,739
	10 20 30 40 50 60 MAFIEKGQEI DMEVIKAETQ LSAEALRLKE SRDRELADII SGEDDRILLV IGPCSSDNEE 70 80 90 100 110 120 AVLEYARRLS ALQKKVADKI FMVMRVYTAK PRTNGDGYKG LVHQPDTSKA PSLINGLQAV 130 140 150 160 170 180 RQLHYRVITE TGLTTADEML YPSNLILVDD LVSYHAVGAR SVEDQEHRFV ASGIDAPVGM 190 200 210 220 230 240 KNPTSGNLGV MFNAIYAAQN KQTFLYHGQE VETSGNPLAH VILRGAVNEY GNYMPNYYYE 250 260 270 280 290 300 NLLQAIERYE TMGLENPFIL IDTNHDNSGK QYMEQIRIVR QTLQNRDWNE KIKKTVRGFM 310 320 330 340 IESYLADGRQ NQPEVFGCSI TDPCLGWENT EALVEEIYVT LTK

References

[1]

"Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate." Dopazo J., Mendoza A., Herrero J., Caldara F., Humbert Y., Friedli L., Guerrier M., Grand-Schenk E., Gandin C., de Francesco M., Polissi A., Buell G., Feger G., Garcia E., Peitsch M., Garcia-Bustos J.F. Microb. Drug Resist. 7:99-125(2001) [PubMed: 11442348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: G54 EMBL ACF54826.1.

[2]

"Pneumococcal beta glucoside metabolism investigated by whole genome comparison." Mulas L., Trappetti C., Hakenbeck R., Iannelli F., Pozzi G., Davidsen T.M., Tettelin H., Oggioni M. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: G54 EMBL ACF54826.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001015 Genomic DNA. Translation: ACF54826.1.
RefSeq	YP_002038311.1. NC_011072.1.
3D structure databases
ProteinModelPortal	B5E747.
ModBase	Search...
Protein-protein interaction databases
STRING	B5E747.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000022484; EBSTRP00000021650; EBSTRG00000022484.
GeneID	6479024.
GenomeReviews	Gene locus SPG_1606 in contig CP001015_GR.
KEGG	spx:SPG_1606.
PATRIC	19688859. VBIStrPne77426_1681.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000028141.
HOGENOM	HBG670536.
OMA	MDNSFKL.
ProtClustDB	PRK09261.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5E747_STRP4

Accession

Primary (citable) accession number: B5E747

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)