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B5E5J9

- PUR9_STRP4

UniProt

B5E5J9 - PUR9_STRP4

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, SPG_0056
Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSPNE512566:GCA3-56-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SPG_0056
OrganismiStreptococcus pneumoniae serotype 19F (strain G54)
Taxonomic identifieri512566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008334: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000096100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi512566.SPG_0056.

Structurei

3D structure databases

ProteinModelPortaliB5E5J9.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B5E5J9-1 [UniParc]FASTAAdd to Basket

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MTKRVLISVS DKAGIVEFAQ ELKKLGWEII STGGTKVALD NAGVDTIAID    50
DMTGFPEMMD GRVKTLHPNI HGGLLARRDL DSHLEAAKDN KIELIDLVVV 100
NLYPFKETIL KPDVTYADAV ENIDIGGPSM LRSAAKNHAS VTVVVDPADY 150
AVVLDELSAN GETTYETRQR LAAKVFRHTA AYDALIAEYF TAQVGESKPE 200
KLTLTYDLKQ AMRYGENPQQ DADFYQKALP TDYSIASAKQ LNGKELSFNN 250
IRDADAAIRI IRDFKDRPTV VALKHMNPCG IGQADNIETA WDYAYESDPV 300
SIFGGIVVLN REVDAATAEK MHGVFLEIII APSYTDEALA ILINKKKNLR 350
ILALPFNAQE ASEVEAEYTG VVGGLLVQNQ DVVKESPADW QVVTKRQPTE 400
TEATALEFAW KAIKYVKSNG IIVTNDHMTL GVGPGQTNRV ASVRLAIDQA 450
KDRLNGAVLA SDAFFPFADN VEEIAKAGIK AIIQPGGSVR DQESIEAADK 500
YGLTMVFTGV RHFRH 515
Length:515
Mass (Da):56,397
Last modified:October 14, 2008 - v1
Checksum:iE46354F9CEAC886C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001015 Genomic DNA. Translation: ACF55031.1.
RefSeqiYP_002036771.1. NC_011072.1.

Genome annotation databases

EnsemblBacteriaiACF55031; ACF55031; SPG_0056.
GeneIDi6479017.
KEGGispx:SPG_0056.
PATRICi19685597. VBIStrPne77426_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001015 Genomic DNA. Translation: ACF55031.1 .
RefSeqi YP_002036771.1. NC_011072.1.

3D structure databases

ProteinModelPortali B5E5J9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 512566.SPG_0056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACF55031 ; ACF55031 ; SPG_0056 .
GeneIDi 6479017.
KEGGi spx:SPG_0056.
PATRICi 19685597. VBIStrPne77426_0053.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SPNE512566:GCA3-56-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G54.
  2. "Pneumococcal beta glucoside metabolism investigated by whole genome comparison."
    Mulas L., Trappetti C., Hakenbeck R., Iannelli F., Pozzi G., Davidsen T.M., Tettelin H., Oggioni M.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G54.

Entry informationi

Entry nameiPUR9_STRP4
AccessioniPrimary (citable) accession number: B5E5J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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