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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:SPG_0005
OrganismiStreptococcus pneumoniae serotype 19F (strain G54)
Taxonomic identifieri512566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000929911 – 189Peptidyl-tRNA hydrolaseAdd BLAST189

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5E572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004797.
KOiK01056.
OMAiKSLDAHC.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5E572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLLVGLGN PGDKYFETKH NVGFMLIDQL AKKQNVTFTH DKIFQADLAS
60 70 80 90 100
FFLNGEKIYL VKPTTFMNES GKAVHALLTY YGLDIDDLLI IYDDLDMEVG
110 120 130 140 150
KIRLRAKGSA GGHNGIKSII QHIGTQVFNR VKIGIGRPKN GMSVVHHVLS
160 170 180
KFDRDDYIGI LQSVDKVDDS VNYYLQEKNF EKTMQRYNG
Length:189
Mass (Da):21,391
Last modified:October 14, 2008 - v1
Checksum:i68BE01DCA04BEB12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001015 Genomic DNA. Translation: ACF56061.1.
RefSeqiWP_000163932.1. NC_011072.1.

Genome annotation databases

EnsemblBacteriaiACF56061; ACF56061; SPG_0005.
KEGGispx:SPG_0005.
PATRICi19685489. VBIStrPne77426_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001015 Genomic DNA. Translation: ACF56061.1.
RefSeqiWP_000163932.1. NC_011072.1.

3D structure databases

ProteinModelPortaliB5E572.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF56061; ACF56061; SPG_0005.
KEGGispx:SPG_0005.
PATRICi19685489. VBIStrPne77426_0005.

Phylogenomic databases

HOGENOMiHOG000004797.
KOiK01056.
OMAiKSLDAHC.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiIPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
[Graphical view]
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiPF01195. Pept_tRNA_hydro. 1 hit.
[Graphical view]
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiPS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_STRP4
AccessioniPrimary (citable) accession number: B5E572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.