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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:SPG_1101
OrganismiStreptococcus pneumoniae serotype 19F (strain G54)
Taxonomic identifieri512566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001220941 – 446Exodeoxyribonuclease 7 large subunitAdd BLAST446

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5E4U5.
SMRiB5E4U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

B5E4U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYLSVTTL TKYLKMKFDK DPYLERVYLT GQVSNFRKRP THQYFSLKDD
60 70 80 90 100
HAVIQATIWS GIYQKLGFDL EEGMKINVIG RVQVYEPSGS YSIIIEKAEP
110 120 130 140 150
DGVGALAIQF EQLKKKLTEE GLFQERFKQA LPQFSKRIGV VTSRSGAVIR
160 170 180 190 200
DIITTVSRRF PGVDILLYPT KVQGEGAAEE IARNIARANQ RDDLDLLIIG
210 220 230 240 250
RGGGSIEDLW AFNEEIVVRA IFESRLPVIS SVGHETDVTL ADFVADRRAA
260 270 280 290 300
TPTAAAELAT PVTKLDVLAH LQNQEKRMVT AVRNVLSKKQ EALKKCSQSV
310 320 330 340 350
IFRQPERLYD GYLQRLDQLQ LRLKQSLRTR ISDNKQLVQA RTHQLVQLSP
360 370 380 390 400
VTKIQRYQDR LGQLDKLLGS QMALVYDAKV AEVKRLSEAL LMLDTSRIVA
410 420 430 440
RGYAIVKKEE SVVDSVESLK KKDQVTLLMR DGQVELEVKD VKTKEI
Length:446
Mass (Da):50,536
Last modified:October 14, 2008 - v1
Checksum:i9B2E1B8D25BBB991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001015 Genomic DNA. Translation: ACF56089.1.
RefSeqiWP_000417465.1. NC_011072.1.

Genome annotation databases

EnsemblBacteriaiACF56089; ACF56089; SPG_1101.
KEGGispx:SPG_1101.
PATRICi19687819. VBIStrPne77426_1161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001015 Genomic DNA. Translation: ACF56089.1.
RefSeqiWP_000417465.1. NC_011072.1.

3D structure databases

ProteinModelPortaliB5E4U5.
SMRiB5E4U5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACF56089; ACF56089; SPG_1101.
KEGGispx:SPG_1101.
PATRICi19687819. VBIStrPne77426_1161.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiENAQVRC.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_STRP4
AccessioniPrimary (citable) accession number: B5E4U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.