B5E4S5 (B5E4S5_STRP4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phospho-beta-galactosidase 2 HAMAP MF_01574
EC=3.2.1.85 HAMAP MF_01574

Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 2 HAMAP MF_01574
P-beta-Gal 2 HAMAP MF_01574

Gene names

Name:	lacG EMBL ACF55578.1
Synonyms:	lacG2 HAMAP MF_01574
Ordered Locus Names:	SPG_1081

Organism

Streptococcus pneumoniae serotype 19F (strain G54) [Complete proteome] [HAMAP] EMBL ACF55578.1

Taxonomic identifier

512566 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574
Pathway	Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574
Sequence similarities	Belongs to the glycosyl hydrolase 1 family. HAMAP MF_01574

Ontologies

Keywords
Molecular function	Glycosidase HAMAP MF_01574 EMBL ACF55578.1 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	6-phospho-beta-galactosidase activity Inferred from electronic annotation. Source: HAMAP cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	160	1	Proton donor By similarity HAMAP MF_01574
	Active site	375	1	Nucleophile By similarity HAMAP MF_01574

Sequences

	Sequence		Length	Mass (Da)
	B5E4S5 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 50371C80745EFF17	FASTA	468	53,932
	10 20 30 40 50 60 MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS DFYNRYPVDL 70 80 90 100 110 120 KLAEEYGVNG IRISIAWSRI FPTGYGQVNA KGVEFYHNLF AECHKRHVEP FVTLHHFDTP 130 140 150 160 170 180 EALHSNGDFL NRENIEHFVD YAAFCFEEFP EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY 190 200 210 220 230 240 DLAKVFQSHH NMMVSHARAV KLYKEKGYKG EIGVVHALPT KYPLDPENPA DVRAAELEDI 250 260 270 280 290 300 IHNKFILDAT YLGRYSAETM EGVNHILSVN GGSLDLREED FTTLEAAKDL NDFLGINYYM 310 320 330 340 350 360 SDWMEAFDGE TEIIHNGKGE KGSSKYQIKG VGRRVAPDYV PRTDWDWIIY PQGLYDQIMR 370 380 390 400 410 420 VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ HLEILSDAIA DGANVKGYFI 430 440 450 460 WSLMDVFSWS NGYEKRYGLF YVDFETQERY PKKSAHWYKK VAETQIID

References

[1]

"Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate." Dopazo J., Mendoza A., Herrero J., Caldara F., Humbert Y., Friedli L., Guerrier M., Grand-Schenk E., Gandin C., de Francesco M., Polissi A., Buell G., Feger G., Garcia E., Peitsch M., Garcia-Bustos J.F. Microb. Drug Resist. 7:99-125(2001) [PubMed: 11442348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: G54 EMBL ACF55578.1.

[2]

"Pneumococcal beta glucoside metabolism investigated by whole genome comparison." Mulas L., Trappetti C., Hakenbeck R., Iannelli F., Pozzi G., Davidsen T.M., Tettelin H., Oggioni M. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: G54 EMBL ACF55578.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001015 Genomic DNA. Translation: ACF55578.1.
RefSeq	YP_002037791.1. NC_011072.1.
3D structure databases
ProteinModelPortal	B5E4S5.
ModBase	Search...
Protein-protein interaction databases
STRING	B5E4S5.
Protein family/group databases
CAZy	GH1. Glycoside Hydrolase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000021911; EBSTRP00000021077; EBSTRG00000021911.
GeneID	6479739.
GenomeReviews	Gene locus SPG_1081 in contig CP001015_GR.
KEGG	spx:SPG_1081.
PATRIC	19687777. VBIStrPne77426_1140.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027409.
HOGENOM	HBG316462.
OMA	PTGYGEV.
ProtClustDB	PRK13511.
Family and domain databases
HAMAP	MF_01574. LacG. [Tree]
InterPro	IPR005928. 6P-beta-galactosidase. IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K01220.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMs	TIGR01233. LacG. 1 hit.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5E4S5_STRP4

Accession

Primary (citable) accession number: B5E4S5

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)