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Protein

NAD kinase

Gene

nadK

Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei50Proton acceptorUniRule annotation1
Binding sitei152NADUniRule annotation1
Binding sitei154NADUniRule annotation1
Binding sitei189NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 51NADUniRule annotation2
Nucleotide bindingi126 – 127NADUniRule annotation2
Nucleotide bindingi165 – 170NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE512566:G1GBM-1073-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:SPG_1018
OrganismiStreptococcus pneumoniae serotype 19F (strain G54)
Taxonomic identifieri512566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001208901 – 272NAD kinaseAdd BLAST272

Proteomic databases

PRIDEiB5E4L2

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B5E4L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTGKRIDL IANRKPQXQR VLYELRDRLK RNQFILNXTN PDIVISIGGD
60 70 80 90 100
GMLLSAFHKY ENQLDKVRFI GLHTGHLGFY TDYRDFELDK LVTNLQLDTG
110 120 130 140 150
ARVSYPVLNV KVFLENGEVK IFRALNEASI RRSDRTMVAD IVINGVPFER
160 170 180 190 200
FRGDGLTVST PTGSTAYNKS LGGAVLHPTI EALQLTEIAS LNNRVYRTLG
210 220 230 240 250
SSIIVPKKDK IELIPTRNDY HTISVDNSVY SFRNIERIEY QIDHHKIHFV
260 270
ATPSHTSFWN RVKDAFIGEV DE
Length:272
Mass (Da):31,056
Last modified:October 14, 2008 - v1
Checksum:i39C8FC194A1E794B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001015 Genomic DNA Translation: ACF55804.1
RefSeqiWP_000799061.1, NC_011072.1

Genome annotation databases

EnsemblBacteriaiACF55804; ACF55804; SPG_1018
KEGGispx:SPG_1018

Similar proteinsi

Entry informationi

Entry nameiNADK_STRP4
AccessioniPrimary (citable) accession number: B5E4L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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