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B5E320

- THIM1_STRP4

UniProt

B5E320 - THIM1_STRP4

Protein

Hydroxyethylthiazole kinase 1

Gene

thiM1

Organism
Streptococcus pneumoniae serotype 19F (strain G54)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391Substrate; via amide nitrogenUniRule annotation
    Binding sitei115 – 1151ATPUniRule annotation
    Binding sitei160 – 1601ATPUniRule annotation
    Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE512566:GCA3-650-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinase 1UniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase 1UniRule annotation
    Short name:
    TH kinase 1UniRule annotation
    Short name:
    Thz kinase 1UniRule annotation
    Gene namesi
    Name:thiM1UniRule annotation
    Ordered Locus Names:SPG_0650
    OrganismiStreptococcus pneumoniae serotype 19F (strain G54)
    Taxonomic identifieri512566 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000008334: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Hydroxyethylthiazole kinase 1PRO_1000100427Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi512566.SPG_0650.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiTISESTY.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5E320-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLKLLKKK APLVICITND VVKNFTANGL VALGASPAMS EFPADLEDLL    50
    KYAGGLLINI GTLTDENWKL YQAALKIAEK YNVPAVLDPV ACGAGEYRKK 100
    VADDLINNYK LAAIRGNAGE IASLVGIDVA SKGVDSAGVD NIDEIALAAN 150
    EKFNIPIVVT GEVDAIAVNG EVVTIHNGSA MMPKVIGTGC LLGAVVASFI 200
    GLEKGQELKS LETAMLVYNI AGEMAEKRPN GHLPGTFKVE FINALYEITD 250
    EDVKEFKRVK 260
    Length:260
    Mass (Da):27,606
    Last modified:October 14, 2008 - v1
    Checksum:iFA3C8552508049BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001015 Genomic DNA. Translation: ACF54849.1.
    RefSeqiYP_002037365.1. NC_011072.1.

    Genome annotation databases

    EnsemblBacteriaiACF54849; ACF54849; SPG_0650.
    GeneIDi6479907.
    KEGGispx:SPG_0650.
    PATRICi19686861. VBIStrPne77426_0690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001015 Genomic DNA. Translation: ACF54849.1 .
    RefSeqi YP_002037365.1. NC_011072.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 512566.SPG_0650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACF54849 ; ACF54849 ; SPG_0650 .
    GeneIDi 6479907.
    KEGGi spx:SPG_0650.
    PATRICi 19686861. VBIStrPne77426_0690.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi TISESTY.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci SPNE512566:GCA3-650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G54.
    2. "Pneumococcal beta glucoside metabolism investigated by whole genome comparison."
      Mulas L., Trappetti C., Hakenbeck R., Iannelli F., Pozzi G., Davidsen T.M., Tettelin H., Oggioni M.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G54.

    Entry informationi

    Entry nameiTHIM1_STRP4
    AccessioniPrimary (citable) accession number: B5E320
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3