Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-like protein

Gene

Dpse\GA26655

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dpse\GA26655Imported
ORF Names:Dpse_GA26655Imported, GA26655Imported
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001819 Componenti: Chromosome 2

Organism-specific databases

FlyBaseiFBgn0248028. Dpse\GA26655.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini214 – 25845DSLInterPro annotationAdd
BLAST
Domaini259 – 29234EGF-likeInterPro annotationAdd
BLAST
Domaini326 – 36439EGF-likeInterPro annotationAdd
BLAST
Domaini465 – 50137EGF-likeInterPro annotationAdd
BLAST
Domaini551 – 58838EGF-likeInterPro annotationAdd
BLAST
Domaini590 – 62536EGF-likeInterPro annotationAdd
BLAST
Domaini627 – 66337EGF-likeInterPro annotationAdd
BLAST
Domaini665 – 70036EGF-likeInterPro annotationAdd
BLAST
Domaini744 – 78037EGF-likeInterPro annotationAdd
BLAST
Domaini782 – 81837EGF-likeInterPro annotationAdd
BLAST
Domaini820 – 86041EGF-likeInterPro annotationAdd
BLAST
Domaini862 – 89837EGF-likeInterPro annotationAdd
BLAST
Domaini900 – 93637EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.UniRule annotation
Contains 14 EGF-like domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

InParanoidiB5DWT5.
KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DWT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTTTTTTQ RQRQRQRQRP RQREFSALPS TISDCRSLKS ACNLIALILI
60 70 80 90 100
LLVHKISAAG NFELEILEIS NTNSHLLSGY CCGMPPELRA TKTTGCSPCT
110 120 130 140 150
TAFRLCLKEY QTTEQGASIS TGCSFGNSTT KILGGSSFVL SDPGVGAIVL
160 170 180 190 200
PFTFRWTKSF TLILQALDMY NTSYPDAERL IEETSYSGVI LPSPEWKTLD
210 220 230 240 250
HIGRNARITY RVRVQCAVTY YNTTCTTFCR PRDDQFGHYA CGSEGQKLCL
260 270 280 290 300
NGWQGVNCEE AICKTGCDPV HGKCDRPGEC ECRPGWRGPL CNECMVYPGC
310 320 330 340 350
KHGSCNGSAW KCVCDTNWGG ILCDQDLNYC GTHEPCKHGG TCENTAPDQY
360 370 380 390 400
RCTCAEGLSG EQCEIVEHPC ATQPCRNGGT CTLKPMNATR PPVYRIMRGM
410 420 430 440 450
STSMGKPISR RNSIRSLANL RQESQNGSSN GGALGSSPGL PLTPLAAEFT
460 470 480 490 500
CGCAAGWTGP TCEINIDECA GGPCEHGGTC VDLIGGFRCE CPPEWRGDVC
510 520 530 540 550
QVDVNECEVP HAAQAVSANT LLTTTMASAA IGSNLSSSAA LLAALTSAVA
560 570 580 590 600
ASNAASTIGP CINARECINE PGSFSCQCLE GWGGATCAEN LDDCMGQCKN
610 620 630 640 650
GASCIDLVND YRCACGPGYT GRDCETDIDE CATSPCRNGG ECVDMIGKFN
660 670 680 690 700
CICPLGYSGS LCEEAKDHCT PSPCLQGRCL NTPGSYYCHC PPDRAGKHCE
710 720 730 740 750
QLRPLCSQPP CNEGCFANVS SIATGTAAAA AAAASAGTTT TTTTMTTPSG
760 770 780 790 800
LPCSGHGSCE MSDVGTFCKC HVGHTGTFCE HNLNECSPNP CRNGGICLDG
810 820 830 840 850
DGDFTCECMS GWTGKRCSER ATGCYAGQCQ NGGTCMPGAP DKALQPHCRC
860 870 880 890 900
APGWTGLFCA ESIDQCRGQP CHNGGTCESG AGWFRCLCAQ GFSGPDCRIN
910 920 930 940 950
VNECSPQPCQ GGATCIDGIG GYSCICPPGR HGLRCEILLS DPKSACLNAS
960 970 980 990 1000
NTISPYAALN QSQNWLDTAL SGRSEDDEHC NACVCENGTS RCTNLWCGLP
1010 1020 1030 1040 1050
NCYKLDPLSK SSNLSGVCKQ HEVCVPALSE TCLSPPCNVR GDCRALEPSR
1060 1070 1080 1090 1100
RVAPPSLPAK ASCWPNQALV NENCARLTIL LDLERVGRGA SVEGLCSLVR
1110 1120 1130 1140 1150
VLLAAQLVKQ PPSAPSQEPG LLMVLCDLKS GSNDTVELTV SSSKLNDPQL
1160 1170 1180 1190 1200
PVAVALLGEL LSSRQLNGIQ RRKELELQHA KLAALTSILE VKLETARVAD
1210 1220 1230 1240 1250
GSGHSLLIGV LCGVFIVLVG FSIFISLYWK QRLAYRSSSG MNLTPSLDAL
1260 1270 1280 1290 1300
RHEEEKSNNL QNEENLRRYT NPIKGSTSSL RSTTGMELSL NPAPELAATA
1310 1320 1330 1340 1350
ASSSALHRSQ PLFPPCDFER ELDSSTGLKQ AHKRGSQILL HKTQNLDMKK
1360 1370 1380 1390
NTVGSLDSPR KDFGKRSINC KSLPPPACDD GVDVLTTVMV
Length:1,390
Mass (Da):148,008
Last modified:January 20, 2016 - v2
Checksum:i7C0A7D3FBB219D83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EDY67819.2.
RefSeqiXP_002137261.2. XM_002137225.2.

Genome annotation databases

EnsemblMetazoaiFBtr0283950; FBpp0282388; FBgn0248028.
GeneIDi6897077.
KEGGidpo:Dpse_GA26655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000070 Genomic DNA. Translation: EDY67819.2.
RefSeqiXP_002137261.2. XM_002137225.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0283950; FBpp0282388; FBgn0248028.
GeneIDi6897077.
KEGGidpo:Dpse_GA26655.

Organism-specific databases

FlyBaseiFBgn0248028. Dpse\GA26655.

Phylogenomic databases

InParanoidiB5DWT5.
KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94Imported.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 Genomes Consortium
    Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.
    , Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94Imported.

Entry informationi

Entry nameiB5DWT5_DROPS
AccessioniPrimary (citable) accession number: B5DWT5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: January 20, 2016
Last modified: June 8, 2016
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.