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B5DKS8

- SWS_DROPS

UniProt

B5DKS8 - SWS_DROPS

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei977 – 9771By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 303128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi474 – 601128cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi590 – 717128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GA22927
    OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
    Taxonomic identifieri46245 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001819: Partially assembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0244329. Dpse\GA22927.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14941494Neuropathy target esterase swsPRO_0000389225Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei443 – 4431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiB5DKS8.

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7237.FBpp0273301.

    Structurei

    3D structure databases

    ProteinModelPortaliB5DKS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535LumenalSequence AnalysisAdd
    BLAST
    Topological domaini57 – 14941438CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini944 – 1110167PatatinSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    KOiK14676.
    OrthoDBiEOG7QRQT1.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5DKS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI     50
    GWFVYFKRLA RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR 100
    MLRKMKNVSG QMYSSGKGYK RRAVIRFARR ILQLRRENMP LEVRTVEPPA 150
    EYLEETMEGS DRVPPDALYM LQSIRIFGHF EKPIFLRLCK HTQLLELMGG 200
    DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK GESVTSLLSF 250
    IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI 300
    MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT 350
    GSASATASAA AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN 400
    LELSGDSVNT LFGEVNGGAR LNSYPPLYHQ RESDGNLSTR RGSITQQEQP 450
    EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ DAHIIDPFVE VREMEPNVTL 500
    ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI HYVHPGEIVG 550
    GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR 600
    RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG 650
    GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK 700
    LRYPIVVTKL ISFLSHRFLG SMQTRTTTGA PGAPVEANPV THKYSTVALV 750
    PITDDVPLTP FTYELYHSLC AIGPVLRLTS DLARKQLGMN IFDASNEYRL 800
    TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG LGDHSHLVGK 850
    FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV 900
    KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG 950
    ARGAAHIGML KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR 1000
    EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHETFGDV NIEDLWIPYF 1050
    TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK DGHLLLDGGY 1100
    VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT NNVPADVMHN 1150
    LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD 1200
    IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS FDEIRDVGYV 1250
    FGKNYFEGMA KAGRLGRFNQ WFSKEPPKRG NHASLNEYTF IDLAQIVCRL 1300
    PETYGLNPSD LFSEDEDCDG YISEPTTLNT DVRRYQVPRG GNSLSLSETE 1350
    MDMDSDVEMD LKMERKMDKA TQSTPPLQSK AQILRRKHSK EEARHEWEIK 1400
    REQKQELARE QELERERELS QKGTTAGATG YTPNAVIATQ TSLIFMDEED 1450
    EMDKKKTKDN DRDEVRGSAE DKGKEKEEDK ENRSNTNNET KNYL 1494
    Length:1,494
    Mass (Da):168,444
    Last modified:October 14, 2008 - v1
    Checksum:i6F53A60DFB6E7999
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379063 Genomic DNA. Translation: EDY72128.1.
    RefSeqiXP_002133500.1. XM_002133464.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0274863; FBpp0273301; FBgn0244329.
    GeneIDi6901966.
    KEGGidpo:Dpse_GA22927.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH379063 Genomic DNA. Translation: EDY72128.1 .
    RefSeqi XP_002133500.1. XM_002133464.1.

    3D structure databases

    ProteinModelPortali B5DKS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7237.FBpp0273301.

    Proteomic databases

    PRIDEi B5DKS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0274863 ; FBpp0273301 ; FBgn0244329 .
    GeneIDi 6901966.
    KEGGi dpo:Dpse_GA22927.

    Organism-specific databases

    FlyBasei FBgn0244329. Dpse\GA22927.

    Phylogenomic databases

    eggNOGi COG0664.
    KOi K14676.
    OrthoDBi EOG7QRQT1.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
      Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
      , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
      Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MV2-25 / Tucson 14011-0121.94.

    Entry informationi

    Entry nameiSWS_DROPS
    AccessioniPrimary (citable) accession number: B5DKS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3