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B5DKS8 (SWS_DROPS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GA22927
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly) [Reference proteome]
Taxonomic identifier46245 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14941494Neuropathy target esterase sws
PRO_0000389225

Regions

Topological domain1 – 3535Lumenal Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 14941438Cytoplasmic Potential
Domain944 – 1110167Patatin
Nucleotide binding176 – 303128cNMP 1
Nucleotide binding474 – 601128cNMP 2
Nucleotide binding590 – 717128cNMP 3

Sites

Active site9771 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4431Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B5DKS8 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 6F53A60DFB6E7999

FASTA1,494168,444
        10         20         30         40         50         60 
MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI GWFVYFKRLA 

        70         80         90        100        110        120 
RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR MLRKMKNVSG QMYSSGKGYK 

       130        140        150        160        170        180 
RRAVIRFARR ILQLRRENMP LEVRTVEPPA EYLEETMEGS DRVPPDALYM LQSIRIFGHF 

       190        200        210        220        230        240 
EKPIFLRLCK HTQLLELMGG DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK 

       250        260        270        280        290        300 
GESVTSLLSF IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI 

       310        320        330        340        350        360 
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT GSASATASAA 

       370        380        390        400        410        420 
AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN LELSGDSVNT LFGEVNGGAR 

       430        440        450        460        470        480 
LNSYPPLYHQ RESDGNLSTR RGSITQQEQP EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ 

       490        500        510        520        530        540 
DAHIIDPFVE VREMEPNVTL ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI 

       550        560        570        580        590        600 
HYVHPGEIVG GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR 

       610        620        630        640        650        660 
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG GKKEIVGEYG 

       670        680        690        700        710        720 
KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK LRYPIVVTKL ISFLSHRFLG 

       730        740        750        760        770        780 
SMQTRTTTGA PGAPVEANPV THKYSTVALV PITDDVPLTP FTYELYHSLC AIGPVLRLTS 

       790        800        810        820        830        840 
DLARKQLGMN IFDASNEYRL TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG 

       850        860        870        880        890        900 
LGDHSHLVGK FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV 

       910        920        930        940        950        960 
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG ARGAAHIGML 

       970        980        990       1000       1010       1020 
KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR EWSKKMTKWF LQLLDLTYPI 

      1030       1040       1050       1060       1070       1080 
TSMFSGREFN KTIHETFGDV NIEDLWIPYF TLTTDITASC HRIHTNGSLW RYVRSSMSLS 

      1090       1100       1110       1120       1130       1140 
GYMPPLCDPK DGHLLLDGGY VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT 

      1150       1160       1170       1180       1190       1200 
NNVPADVMHN LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD 

      1210       1220       1230       1240       1250       1260 
IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS FDEIRDVGYV FGKNYFEGMA 

      1270       1280       1290       1300       1310       1320 
KAGRLGRFNQ WFSKEPPKRG NHASLNEYTF IDLAQIVCRL PETYGLNPSD LFSEDEDCDG 

      1330       1340       1350       1360       1370       1380 
YISEPTTLNT DVRRYQVPRG GNSLSLSETE MDMDSDVEMD LKMERKMDKA TQSTPPLQSK 

      1390       1400       1410       1420       1430       1440 
AQILRRKHSK EEARHEWEIK REQKQELARE QELERERELS QKGTTAGATG YTPNAVIATQ 

      1450       1460       1470       1480       1490 
TSLIFMDEED EMDKKKTKDN DRDEVRGSAE DKGKEKEEDK ENRSNTNNET KNYL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH379063 Genomic DNA. Translation: EDY72128.1.
RefSeqXP_002133500.1. XM_002133464.1.

3D structure databases

ProteinModelPortalB5DKS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7237.FBpp0273301.

Proteomic databases

PRIDEB5DKS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0274863; FBpp0273301; FBgn0244329.
GeneID6901966.
KEGGdpo:Dpse_GA22927.

Organism-specific databases

FlyBaseFBgn0244329. Dpse\GA22927.

Phylogenomic databases

eggNOGCOG0664.
KOK14676.
OrthoDBEOG7QRQT1.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROPS
AccessionPrimary (citable) accession number: B5DKS8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase