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B5DKS8

- SWS_DROPS

UniProt

B5DKS8 - SWS_DROPS

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Protein
Neuropathy target esterase sws
Gene
sws, GA22927
Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei977 – 9771 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 303128cNMP 1
Add
BLAST
Nucleotide bindingi474 – 601128cNMP 2
Add
BLAST
Nucleotide bindingi590 – 717128cNMP 3
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GA22927
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0244329. Dpse\GA22927.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Lumenal Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Topological domaini57 – 14941438Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14941494Neuropathy target esterase sws
PRO_0000389225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei443 – 4431Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB5DKS8.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0273301.

Structurei

3D structure databases

ProteinModelPortaliB5DKS8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini944 – 1110167Patatin
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
KOiK14676.
OrthoDBiEOG7QRQT1.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DKS8-1 [UniParc]FASTAAdd to Basket

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MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI     50
GWFVYFKRLA RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR 100
MLRKMKNVSG QMYSSGKGYK RRAVIRFARR ILQLRRENMP LEVRTVEPPA 150
EYLEETMEGS DRVPPDALYM LQSIRIFGHF EKPIFLRLCK HTQLLELMGG 200
DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK GESVTSLLSF 250
IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI 300
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT 350
GSASATASAA AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN 400
LELSGDSVNT LFGEVNGGAR LNSYPPLYHQ RESDGNLSTR RGSITQQEQP 450
EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ DAHIIDPFVE VREMEPNVTL 500
ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI HYVHPGEIVG 550
GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR 600
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG 650
GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK 700
LRYPIVVTKL ISFLSHRFLG SMQTRTTTGA PGAPVEANPV THKYSTVALV 750
PITDDVPLTP FTYELYHSLC AIGPVLRLTS DLARKQLGMN IFDASNEYRL 800
TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG LGDHSHLVGK 850
FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV 900
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG 950
ARGAAHIGML KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR 1000
EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHETFGDV NIEDLWIPYF 1050
TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK DGHLLLDGGY 1100
VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT NNVPADVMHN 1150
LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD 1200
IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS FDEIRDVGYV 1250
FGKNYFEGMA KAGRLGRFNQ WFSKEPPKRG NHASLNEYTF IDLAQIVCRL 1300
PETYGLNPSD LFSEDEDCDG YISEPTTLNT DVRRYQVPRG GNSLSLSETE 1350
MDMDSDVEMD LKMERKMDKA TQSTPPLQSK AQILRRKHSK EEARHEWEIK 1400
REQKQELARE QELERERELS QKGTTAGATG YTPNAVIATQ TSLIFMDEED 1450
EMDKKKTKDN DRDEVRGSAE DKGKEKEEDK ENRSNTNNET KNYL 1494
Length:1,494
Mass (Da):168,444
Last modified:October 14, 2008 - v1
Checksum:i6F53A60DFB6E7999
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EDY72128.1.
RefSeqiXP_002133500.1. XM_002133464.1.

Genome annotation databases

EnsemblMetazoaiFBtr0274863; FBpp0273301; FBgn0244329.
GeneIDi6901966.
KEGGidpo:Dpse_GA22927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH379063 Genomic DNA. Translation: EDY72128.1 .
RefSeqi XP_002133500.1. XM_002133464.1.

3D structure databases

ProteinModelPortali B5DKS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0273301.

Proteomic databases

PRIDEi B5DKS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0274863 ; FBpp0273301 ; FBgn0244329 .
GeneIDi 6901966.
KEGGi dpo:Dpse_GA22927.

Organism-specific databases

FlyBasei FBgn0244329. Dpse\GA22927.

Phylogenomic databases

eggNOGi COG0664.
KOi K14676.
OrthoDBi EOG7QRQT1.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiSWS_DROPS
AccessioniPrimary (citable) accession number: B5DKS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: October 14, 2008
Last modified: February 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi