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B5DKS8

- SWS_DROPS

UniProt

B5DKS8 - SWS_DROPS

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei977 – 9771By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 303128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi474 – 601128cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi590 – 717128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GA22927
OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)
Taxonomic identifieri46245 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001819: Partially assembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0244329. Dpse\GA22927.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535LumenalSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Topological domaini57 – 14941438CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14941494Neuropathy target esterase swsPRO_0000389225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei443 – 4431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB5DKS8.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7237.FBpp0273301.

Structurei

3D structure databases

ProteinModelPortaliB5DKS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini944 – 1110167PatatinSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB5DKS8.
KOiK14676.
OrthoDBiEOG7QRQT1.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DKS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI
60 70 80 90 100
GWFVYFKRLA RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR
110 120 130 140 150
MLRKMKNVSG QMYSSGKGYK RRAVIRFARR ILQLRRENMP LEVRTVEPPA
160 170 180 190 200
EYLEETMEGS DRVPPDALYM LQSIRIFGHF EKPIFLRLCK HTQLLELMGG
210 220 230 240 250
DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK GESVTSLLSF
260 270 280 290 300
IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI
310 320 330 340 350
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT
360 370 380 390 400
GSASATASAA AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN
410 420 430 440 450
LELSGDSVNT LFGEVNGGAR LNSYPPLYHQ RESDGNLSTR RGSITQQEQP
460 470 480 490 500
EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ DAHIIDPFVE VREMEPNVTL
510 520 530 540 550
ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI HYVHPGEIVG
560 570 580 590 600
GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR
610 620 630 640 650
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG
660 670 680 690 700
GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK
710 720 730 740 750
LRYPIVVTKL ISFLSHRFLG SMQTRTTTGA PGAPVEANPV THKYSTVALV
760 770 780 790 800
PITDDVPLTP FTYELYHSLC AIGPVLRLTS DLARKQLGMN IFDASNEYRL
810 820 830 840 850
TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG LGDHSHLVGK
860 870 880 890 900
FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV
910 920 930 940 950
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG
960 970 980 990 1000
ARGAAHIGML KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR
1010 1020 1030 1040 1050
EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHETFGDV NIEDLWIPYF
1060 1070 1080 1090 1100
TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK DGHLLLDGGY
1110 1120 1130 1140 1150
VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT NNVPADVMHN
1160 1170 1180 1190 1200
LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD
1210 1220 1230 1240 1250
IQSRLAYVSC VRQLEEVKNS DYCEYIRPPI DKYKTLAFGS FDEIRDVGYV
1260 1270 1280 1290 1300
FGKNYFEGMA KAGRLGRFNQ WFSKEPPKRG NHASLNEYTF IDLAQIVCRL
1310 1320 1330 1340 1350
PETYGLNPSD LFSEDEDCDG YISEPTTLNT DVRRYQVPRG GNSLSLSETE
1360 1370 1380 1390 1400
MDMDSDVEMD LKMERKMDKA TQSTPPLQSK AQILRRKHSK EEARHEWEIK
1410 1420 1430 1440 1450
REQKQELARE QELERERELS QKGTTAGATG YTPNAVIATQ TSLIFMDEED
1460 1470 1480 1490
EMDKKKTKDN DRDEVRGSAE DKGKEKEEDK ENRSNTNNET KNYL
Length:1,494
Mass (Da):168,444
Last modified:October 14, 2008 - v1
Checksum:i6F53A60DFB6E7999
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379063 Genomic DNA. Translation: EDY72128.1.
RefSeqiXP_002133500.1. XM_002133464.1.

Genome annotation databases

EnsemblMetazoaiFBtr0274863; FBpp0273301; FBgn0244329.
GeneIDi6901966.
KEGGidpo:Dpse_GA22927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379063 Genomic DNA. Translation: EDY72128.1 .
RefSeqi XP_002133500.1. XM_002133464.1.

3D structure databases

ProteinModelPortali B5DKS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7237.FBpp0273301.

Proteomic databases

PRIDEi B5DKS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0274863 ; FBpp0273301 ; FBgn0244329 .
GeneIDi 6901966.
KEGGi dpo:Dpse_GA22927.

Organism-specific databases

FlyBasei FBgn0244329. Dpse\GA22927.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B5DKS8.
KOi K14676.
OrthoDBi EOG7QRQT1.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution."
    Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S., Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F., Howells S.L.
    , Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F., Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M., Weinstock G.M., Gibbs R.A.
    Genome Res. 15:1-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MV2-25 / Tucson 14011-0121.94.

Entry informationi

Entry nameiSWS_DROPS
AccessioniPrimary (citable) accession number: B5DKS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3