Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fructose-bisphosphate aldolase A

Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in glycolysis and gluconeogenesis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.By similarity
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (G6PI)
  3. ATP-dependent 6-phosphofructokinase (K6PP)
  4. Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALF1), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase A, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (aldA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-PBy similarity
Binding sitei304 – 3041SubstrateBy similarity
Sitei363 – 3631Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase A1 Publication (EC:4.1.2.13By similarity)
Alternative name(s):
Muscle-type aldolaseBy similarity
Allergen: Sal s 3.01011 Publication
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei10151. Sal s 3.
10152. Sal s 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 363362Fructose-bisphosphate aldolase APRO_0000425073Add
BLAST

Interactioni

Subunit structurei

Tetramer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG002386.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5DGM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHAFPFLTP DQKKELSDIA LKIVAKGKGI LAADESTGSV AKRFQSINTE
60 70 80 90 100
NTEENRRLYR QLLFTADDRA GPCIGGVIFF HETLYQKTDA GKTFPEHVKS
110 120 130 140 150
RGWVVGIKVD KGVVPLAGTN GETTTQGLDG LYERCAQYKK DGCDFAKWRC
160 170 180 190 200
VLKITSTTPS RLAIMENCNV LARYASICQM HGIVPIVEPE ILPDGDHDLK
210 220 230 240 250
RTQYVTEKVL AAMYKALSDH HVYLEGTLLK PNMVTAGHSC SHKYTHQEIA
260 270 280 290 300
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SINLNVMNQC PLHRPWALTF
310 320 330 340 350
SYGRALQASA LKAWGGKPGN GKAAQEEFIK RALANSLACQ GKYVASGDSA
360
AAGDSLFVAN HAY
Length:363
Mass (Da):39,556
Last modified:October 14, 2008 - v1
Checksum:i97FF0EA19E1D1C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT043786 mRNA. Translation: ACH70901.1.
BT043787 mRNA. Translation: ACH70902.1.
BT043788 mRNA. Translation: ACH70903.1.
BT043789 mRNA. Translation: ACH70904.1.
BT044037 mRNA. Translation: ACH85353.1.
RefSeqiNP_001133180.1. NM_001139708.1.
NP_001133181.1. NM_001139709.1.
XP_014014713.1. XM_014159238.1.
XP_014014714.1. XM_014159239.1.
UniGeneiSsa.23672.
Ssa.31354.

Genome annotation databases

GeneIDi100194623.
100194624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT043786 mRNA. Translation: ACH70901.1.
BT043787 mRNA. Translation: ACH70902.1.
BT043788 mRNA. Translation: ACH70903.1.
BT043789 mRNA. Translation: ACH70904.1.
BT044037 mRNA. Translation: ACH85353.1.
RefSeqiNP_001133180.1. NM_001139708.1.
NP_001133181.1. NM_001139709.1.
XP_014014713.1. XM_014159238.1.
XP_014014714.1. XM_014159239.1.
UniGeneiSsa.23672.
Ssa.31354.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei10151. Sal s 3.
10152. Sal s 3.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100194623.
100194624.

Phylogenomic databases

HOVERGENiHBG002386.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of full-length sequenced cDNA inserts (FLIcs) from Atlantic salmon (Salmo salar)."
    Andreassen R., Lunner S., Hoyheim B.
    BMC Genomics 10:502-502(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: White muscleImported.
  2. "Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens."
    Kuehn A., Hilger C., Lehners-Weber C., Codreanu-Morel F., Morisset M., Metz-Favre C., Pauli G., de Blay F., Revets D., Muller C.P., Vogel L., Vieths S., Hentges F.
    Clin. Exp. Allergy 43:811-822(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14 AND 323-331, ALLERGEN, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Muscle1 Publication.

Entry informationi

Entry nameiALDOA_SALSA
AccessioniPrimary (citable) accession number: B5DGM7
Secondary accession number(s): B5DGM8, B5DGM9, B5RIB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: October 14, 2008
Last modified: January 20, 2016
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.