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Protein

RNA-binding protein 8A

Gene

rbm8a

Organism
Salmo salar (Atlantic salmon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Nonsense-mediated mRNA decay, Translation regulation, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 8A
Alternative name(s):
RNA-binding motif protein 8A
Ribonucleoprotein RBM8A
Gene namesi
Name:rbm8a
Synonyms:rbm8
OrganismiSalmo salar (Atlantic salmon)
Taxonomic identifieri8030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeSalmo

Subcellular locationi

  • Nucleus By similarity
  • Nucleus speckle By similarity
  • Cytoplasm By similarity

  • Note: Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003785651 – 175RNA-binding protein 8AAdd BLAST175

Interactioni

Subunit structurei

Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a.By similarity

Structurei

3D structure databases

ProteinModelPortaliB5DGI7.
SMRiB5DGI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 151RRMPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the RBM8A family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK12876.

Family and domain databases

CDDicd12324. RRM_RBM8. 1 hit.
Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR008111. RNA-bd_8.
IPR000504. RRM_dom.
IPR033744. RRM_RBM8.
[Graphical view]
PANTHERiPTHR23139:SF72. PTHR23139:SF72. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR01738. RNABINDINGM8.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DGI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVLDLHEA GGEDFAMDED GDDSIHKLKE KAKRRKGRGF GSEEGARSRV
60 70 80 90 100
REDYDTVEQD GDEPGPQRSV EGWILFVTGV HEEATEEDIH DKFAEFGEIK
110 120 130 140 150
NLHLNLDRRT GYLKGYALVE YETYKEAQAA MEGLNGQDMM GQPISVDWGF
160 170
VRGPPKSKRR GGGRRRSRSP DRRRR
Length:175
Mass (Da):19,898
Last modified:October 14, 2008 - v1
Checksum:iA626B6CA99B7D961
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 21Missing in ACM09407 (PubMed:20433749).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT043746 mRNA. Translation: ACH70861.1.
BT057056 mRNA. Translation: ACM08928.1.
BT057535 mRNA. Translation: ACM09407.1.
BT060093 mRNA. Translation: ACN12453.1.
RefSeqiNP_001135168.1. NM_001141696.1.
XP_014056156.1. XM_014200681.1.
UniGeneiSsa.42001.
Ssa.7643.

Genome annotation databases

GeneIDi100196667.
KEGGisasa:100196667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT043746 mRNA. Translation: ACH70861.1.
BT057056 mRNA. Translation: ACM08928.1.
BT057535 mRNA. Translation: ACM09407.1.
BT060093 mRNA. Translation: ACN12453.1.
RefSeqiNP_001135168.1. NM_001141696.1.
XP_014056156.1. XM_014200681.1.
UniGeneiSsa.42001.
Ssa.7643.

3D structure databases

ProteinModelPortaliB5DGI7.
SMRiB5DGI7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100196667.
KEGGisasa:100196667.

Organism-specific databases

CTDi9939.

Phylogenomic databases

KOiK12876.

Family and domain databases

CDDicd12324. RRM_RBM8. 1 hit.
Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR008111. RNA-bd_8.
IPR000504. RRM_dom.
IPR033744. RRM_RBM8.
[Graphical view]
PANTHERiPTHR23139:SF72. PTHR23139:SF72. 1 hit.
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR01738. RNABINDINGM8.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM8A_SALSA
AccessioniPrimary (citable) accession number: B5DGI7
Secondary accession number(s): B9EPG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.