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Protein

Alpha/beta hydrolase domain-containing protein 17C

Gene

Abhd17c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95.By similarity

Catalytic activityi

Palmitoyl-[protein] + H2O = palmitate + [protein].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202Charge relay systemBy similarity1
Active sitei267Charge relay systemBy similarity1
Active sitei296Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha/beta hydrolase domain-containing protein 17CCurated (EC:3.1.2.22By similarity)
Short name:
Abhydrolase domain-containing protein 17CImported
Gene namesi
Name:Abhd17cImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1308210. Abhd17c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004431111 – 320Alpha/beta hydrolase domain-containing protein 17CAdd BLAST320

Post-translational modificationi

Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ3B7U5.
PeptideAtlasiB5DFK7.

Expressioni

Tissue specificityi

Expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000012683.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017362.

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD17 family.Curated

Phylogenomic databases

eggNOGiKOG1552. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007142.
HOVERGENiHBG061270.
OMAiVRCAPNS.
OrthoDBiEOG091G0EV3.
TreeFamiTF314365.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
PfamiView protein in Pfam
PF12146. Hydrolase_4. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DFK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR
60 70 80 90 100
APAPAATPAP APAAQPAPAE EGAGPGACSL HLSERADWQY SQRELDAVEV
110 120 130 140 150
FFSRTARDNR LGCMFVRCAP SSRYTLLFSH GNAVDLGQMC SFYIGLGSRI
160 170 180 190 200
NCNIFSYDYS GYGVSSGKPS EKNLYADIDA AWQALRTRYG VSPENIILYG
210 220 230 240 250
QSIGTVPTVD LASRYECAAV ILHSPLMSGL RVAFPDTRKT YCFDAFPSID
260 270 280 290 300
KISKVTSPVL VIHGTEDEVI DFSHGLAMYE RCPRAVEPLW VEGAGHNDIE
310 320
LYAQYLERLK QFISHELPNS
Length:320
Mass (Da):35,098
Last modified:October 14, 2008 - v1
Checksum:i756E2E43EF5399A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07004495 Genomic DNA. No translation available.
CH473980 Genomic DNA. Translation: EDM08764.1.
BC107461 mRNA. Translation: AAI07462.1.
BC169098 mRNA. Translation: AAI69098.1.
RefSeqiNP_001094206.1. NM_001100736.1.
UniGeneiRn.198511.

Genome annotation databases

EnsembliENSRNOT00000017362; ENSRNOP00000017362; ENSRNOG00000012683.
GeneIDi361601.
KEGGirno:361601.

Similar proteinsi

Entry informationi

Entry nameiAB17C_RAT
AccessioniPrimary (citable) accession number: B5DFK7
Secondary accession number(s): Q3B7U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome