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Protein

Homeobox protein Hox-D9

Gene

Hoxd9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi276 – 335HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D9
Gene namesi
Name:Hoxd9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1582908. Hoxd9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003638621 – 343Homeobox protein Hox-D9Add BLAST343

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059218.

Structurei

3D structure databases

SMRiB5DFK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 142Gly-richAdd BLAST31
Compositional biasi165 – 176Ser/Thr-richAdd BLAST12

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG016849.
InParanoidiB5DFK3.
KOiK09294.
PhylomeDBiB5DFK3.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR006711. Hox9_activation_N.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DFK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAA
60 70 80 90 100
EFASCSFAPK SSVFSASWSA VAAQPPAAAT MSGLYHPYVS PPPLAAAEPG
110 120 130 140 150
RYVRSWMEPL PGFPGGAGGG GGSGGGGGGG SGGPGPVPSP GGPANGRHYG
160 170 180 190 200
IKPETGAAPA PSAASTSSST SSSSSSKRTE CSAARESQGS GGPEFPCNSF
210 220 230 240 250
LRDKAAAAAA AAAGNGPGVG IGTGPGTGGS SEPSACSDHP SPGCPLKEEE
260 270 280 290 300
KQPPQPPQQQ LDPNNPAANW IHARSTRKKR CPYTKYQTLE LEKEFLFNMY
310 320 330 340
LTRDRRYEVA RILNLTERQV KIWFQNRRMK MKKMSKEKCP KGD
Length:343
Mass (Da):35,186
Last modified:October 14, 2008 - v1
Checksum:i8D70DBB1459DC920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC169092 mRNA. Translation: AAI69092.1.
RefSeqiNP_001166940.1. NM_001173469.1.
UniGeneiRn.224625.

Genome annotation databases

GeneIDi688999.
KEGGirno:688999.

Similar proteinsi

Entry informationi

Entry nameiHXD9_RAT
AccessioniPrimary (citable) accession number: B5DFK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families