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Protein

Homeobox protein Hox-D9

Gene

Hoxd9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi276 – 33560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D9
Gene namesi
Name:Hoxd9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1582908. Hoxd9.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Homeobox protein Hox-D9PRO_0000363862Add
BLAST

Expressioni

Gene expression databases

BgeeiENSRNOG00000001580.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi112 – 14231Gly-richAdd
BLAST
Compositional biasi165 – 17612Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG016849.
InParanoidiB5DFK3.
KOiK09294.
PhylomeDBiB5DFK3.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DFK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAA
60 70 80 90 100
EFASCSFAPK SSVFSASWSA VAAQPPAAAT MSGLYHPYVS PPPLAAAEPG
110 120 130 140 150
RYVRSWMEPL PGFPGGAGGG GGSGGGGGGG SGGPGPVPSP GGPANGRHYG
160 170 180 190 200
IKPETGAAPA PSAASTSSST SSSSSSKRTE CSAARESQGS GGPEFPCNSF
210 220 230 240 250
LRDKAAAAAA AAAGNGPGVG IGTGPGTGGS SEPSACSDHP SPGCPLKEEE
260 270 280 290 300
KQPPQPPQQQ LDPNNPAANW IHARSTRKKR CPYTKYQTLE LEKEFLFNMY
310 320 330 340
LTRDRRYEVA RILNLTERQV KIWFQNRRMK MKKMSKEKCP KGD
Length:343
Mass (Da):35,186
Last modified:October 14, 2008 - v1
Checksum:i8D70DBB1459DC920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC169092 mRNA. Translation: AAI69092.1.
RefSeqiNP_001166940.1. NM_001173469.1.
UniGeneiRn.224625.

Genome annotation databases

GeneIDi688999.
KEGGirno:688999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC169092 mRNA. Translation: AAI69092.1.
RefSeqiNP_001166940.1. NM_001173469.1.
UniGeneiRn.224625.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi688999.
KEGGirno:688999.

Organism-specific databases

CTDi3235.
RGDi1582908. Hoxd9.

Phylogenomic databases

HOVERGENiHBG016849.
InParanoidiB5DFK3.
KOiK09294.
PhylomeDBiB5DFK3.

Miscellaneous databases

PROiB5DFK3.

Gene expression databases

BgeeiENSRNOG00000001580.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR006711. Hox9_activation_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF04617. Hox9_act. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXD9_RAT
AccessioniPrimary (citable) accession number: B5DFK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.