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Protein
Submitted name:

Protein Tie1

Gene

Tie1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tie1Imported
Submitted name:
Tie1 proteinImported
Gene namesi
Name:Tie1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621642. Tie1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei760 – 78526HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 11371116Sequence analysisPRO_5007308370Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027414.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini226 – 25732EGF-likeInterPro annotationAdd
BLAST
Domaini265 – 30440EGF-likeInterPro annotationAdd
BLAST
Domaini312 – 34635EGF-likeInterPro annotationAdd
BLAST
Domaini352 – 44392Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini447 – 54498Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini546 – 64196Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini645 – 73894Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini838 – 1117280Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00830000128295.
HOGENOMiHOG000049232.
HOVERGENiHBG007316.
KOiK05120.
OMAiHNSPGAH.
OrthoDBiEOG7966FR.
TreeFamiTF317568.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF12661. hEGF. 1 hit.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5DFD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWWGSPFLL PILFLASHVG ASVDLTLLAN LRITEPQRFF LTCVSGEAGA
60 70 80 90 100
GRSSDVWGPP LLLEKDDRIV RTFPPGQPLH LTRNGSHQVT LRGFSKPSDL
110 120 130 140 150
VGVFSCVGGA GTRRTRVLYV HNSPGAHLFP DKVTHTVNKG DTAVLSARVH
160 170 180 190 200
KEKQTDVIWK NNGSYFHTLD WHEAHDGRFQ LQLQNVQPPS SGIYSATYLE
210 220 230 240 250
ASPLGSAFFR LIVRGCEAGR WGPGCVKDCP GCLHGGVCHD HDGECVCPPG
260 270 280 290 300
FTGTRCEQAC REGRFGQSCQ EQCPGTAGCR GLTFCLPDPY GCSCGSGWRG
310 320 330 340 350
SQCQEACAPG HFGADCRLQC QCQNGGTCDR FSGCVCPSGW HGVHCEKSDR
360 370 380 390 400
IPQILNVATE LEFNLGTMPR INCAAAGNPF PVRGSMELRK PDGTMLLSTK
410 420 430 440 450
AIVEPDRTTA EFEVPRLTLG DSGFWECRVS TSGGQDSRRF KVNVKVPPVP
460 470 480 490 500
LTAPRLLAKQ SRQLVVSPLV SFGGDGPISS VRLHYRPQDS MITWSAIVVD
510 520 530 540 550
PSENVTLMNL KPRTGYNVRV QLSRPGEGGE GAWGPSTLMT TDCPEPLLQP
560 570 580 590 600
WVESWNVEGP DRLRVSWSLP SVPLSGDGFL LRLWDGARGQ ERRENISSPQ
610 620 630 640 650
ARTALLTGLT PGTHYQLDVR LYHCTLLGPA SPSAHVHLPL SGPPAPRHLR
660 670 680 690 700
AQALSDSEIR LMWQHPEAPP GPISKYIVEI QVAGGSGDPQ WMDVDKPEET
710 720 730 740 750
STTVRGLNAS TRYLFRVRAS VQGLGDWSNT VEETTLGNGL QSASPVQESR
760 770 780 790 800
VAEDGLDQQL VLAVVGSVSA TCLTILAALL ALVCIRRSCL HRRHTFTYQS
810 820 830 840 850
GSGEETILQF SSGTLTLTRR PKPQPEPLSY PVLEWEDITF EDLIGEGNFG
860 870 880 890 900
QVIRAMIKKD GLKMNAAIKM LKEYASENDH RDFAGELEVL CKLGHHPNII
910 920 930 940 950
NLLGACENRG YLYIAIEYAP YGNLLDFLRK SRVLETDPAF AREHGTASTL
960 970 980 990 1000
SSRQLLRFAS DAANGMQYLS EKQFIHRDLA ARNVLVGENL ASKIADFGLS
1010 1020 1030 1040 1050
RGEEVYVKKT MGRLPVRWMA IESLNYSVYT TKSDVWSFGV LLWEIVSLGG
1060 1070 1080 1090 1100
TPYCGMTCAE LYEKLPQGYR MEQPRNCDDE VYELMRQCWR DRPYERPPFA
1110 1120 1130
QIALQLGRML EARKAYVNMS LFENFTYAGI DATAEEA
Length:1,137
Mass (Da):125,210
Last modified:October 14, 2008 - v1
Checksum:iB0CA77DA59261E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049769 Genomic DNA. No translation available.
AABR07049770 Genomic DNA. No translation available.
AABR07049771 Genomic DNA. No translation available.
BC169020 mRNA. Translation: AAI69020.1.
RefSeqiNP_445997.1. NM_053545.1.
UniGeneiRn.13171.

Genome annotation databases

EnsembliENSRNOT00000027414; ENSRNOP00000027414; ENSRNOG00000020173.
GeneIDi89806.
KEGGirno:89806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049769 Genomic DNA. No translation available.
AABR07049770 Genomic DNA. No translation available.
AABR07049771 Genomic DNA. No translation available.
BC169020 mRNA. Translation: AAI69020.1.
RefSeqiNP_445997.1. NM_053545.1.
UniGeneiRn.13171.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027414; ENSRNOP00000027414; ENSRNOG00000020173.
GeneIDi89806.
KEGGirno:89806.

Organism-specific databases

CTDi7075.
RGDi621642. Tie1.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00830000128295.
HOGENOMiHOG000049232.
HOVERGENiHBG007316.
KOiK05120.
OMAiHNSPGAH.
OrthoDBiEOG7966FR.
TreeFamiTF317568.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF12661. hEGF. 1 hit.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB5DFD6_RAT
AccessioniPrimary (citable) accession number: B5DFD6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.