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Protein
Submitted name:

Tie1 protein

Gene

Tie1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tie1 proteinImported
Submitted name:
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1Imported
Gene namesi
Name:Tie1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621642. Tie1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei760 – 785HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501049245822 – 1137Sequence analysisAdd BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi247 ↔ 256PROSITE-ProRule annotation
Disulfide bondi269 ↔ 279PROSITE-ProRule annotation
Disulfide bondi294 ↔ 303PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000020173.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027414.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 257EGF-likeInterPro annotationAdd BLAST32
Domaini265 – 304EGF-likeInterPro annotationAdd BLAST40
Domaini312 – 346EGF-likeInterPro annotationAdd BLAST35
Domaini352 – 443Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST92
Domaini447 – 544Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini546 – 641Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini645 – 738Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini838 – 1117Protein kinaseInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137919.
HOGENOMiHOG000049232.
HOVERGENiHBG007316.
KOiK05120.
OMAiFENFTYA.
OrthoDBiEOG091G00RL.
TreeFamiTF317568.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF00041. fn3. 3 hits.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00060. FN3. 3 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 3 hits.
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DFD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWWGSPFLL PILFLASHVG ASVDLTLLAN LRITEPQRFF LTCVSGEAGA
60 70 80 90 100
GRSSDVWGPP LLLEKDDRIV RTFPPGQPLH LTRNGSHQVT LRGFSKPSDL
110 120 130 140 150
VGVFSCVGGA GTRRTRVLYV HNSPGAHLFP DKVTHTVNKG DTAVLSARVH
160 170 180 190 200
KEKQTDVIWK NNGSYFHTLD WHEAHDGRFQ LQLQNVQPPS SGIYSATYLE
210 220 230 240 250
ASPLGSAFFR LIVRGCEAGR WGPGCVKDCP GCLHGGVCHD HDGECVCPPG
260 270 280 290 300
FTGTRCEQAC REGRFGQSCQ EQCPGTAGCR GLTFCLPDPY GCSCGSGWRG
310 320 330 340 350
SQCQEACAPG HFGADCRLQC QCQNGGTCDR FSGCVCPSGW HGVHCEKSDR
360 370 380 390 400
IPQILNVATE LEFNLGTMPR INCAAAGNPF PVRGSMELRK PDGTMLLSTK
410 420 430 440 450
AIVEPDRTTA EFEVPRLTLG DSGFWECRVS TSGGQDSRRF KVNVKVPPVP
460 470 480 490 500
LTAPRLLAKQ SRQLVVSPLV SFGGDGPISS VRLHYRPQDS MITWSAIVVD
510 520 530 540 550
PSENVTLMNL KPRTGYNVRV QLSRPGEGGE GAWGPSTLMT TDCPEPLLQP
560 570 580 590 600
WVESWNVEGP DRLRVSWSLP SVPLSGDGFL LRLWDGARGQ ERRENISSPQ
610 620 630 640 650
ARTALLTGLT PGTHYQLDVR LYHCTLLGPA SPSAHVHLPL SGPPAPRHLR
660 670 680 690 700
AQALSDSEIR LMWQHPEAPP GPISKYIVEI QVAGGSGDPQ WMDVDKPEET
710 720 730 740 750
STTVRGLNAS TRYLFRVRAS VQGLGDWSNT VEETTLGNGL QSASPVQESR
760 770 780 790 800
VAEDGLDQQL VLAVVGSVSA TCLTILAALL ALVCIRRSCL HRRHTFTYQS
810 820 830 840 850
GSGEETILQF SSGTLTLTRR PKPQPEPLSY PVLEWEDITF EDLIGEGNFG
860 870 880 890 900
QVIRAMIKKD GLKMNAAIKM LKEYASENDH RDFAGELEVL CKLGHHPNII
910 920 930 940 950
NLLGACENRG YLYIAIEYAP YGNLLDFLRK SRVLETDPAF AREHGTASTL
960 970 980 990 1000
SSRQLLRFAS DAANGMQYLS EKQFIHRDLA ARNVLVGENL ASKIADFGLS
1010 1020 1030 1040 1050
RGEEVYVKKT MGRLPVRWMA IESLNYSVYT TKSDVWSFGV LLWEIVSLGG
1060 1070 1080 1090 1100
TPYCGMTCAE LYEKLPQGYR MEQPRNCDDE VYELMRQCWR DRPYERPPFA
1110 1120 1130
QIALQLGRML EARKAYVNMS LFENFTYAGI DATAEEA
Length:1,137
Mass (Da):125,210
Last modified:October 14, 2008 - v1
Checksum:iB0CA77DA59261E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049769 Genomic DNA. No translation available.
AABR07049770 Genomic DNA. No translation available.
AABR07049771 Genomic DNA. No translation available.
BC169020 mRNA. Translation: AAI69020.1.
RefSeqiNP_445997.1. NM_053545.1.
UniGeneiRn.13171.

Genome annotation databases

EnsembliENSRNOT00000027414; ENSRNOP00000027414; ENSRNOG00000020173.
GeneIDi89806.
KEGGirno:89806.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB5DFD6_RAT
AccessioniPrimary (citable) accession number: B5DFD6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported