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Protein
Submitted name:

Tie1 protein

Gene

Tie1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tie1 proteinImported
Submitted name:
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1Imported
Gene namesi
Name:Tie1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621642 Tie1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei760 – 785HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501430004922 – 1137Sequence analysisAdd BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi247 ↔ 256PROSITE-ProRule annotation
Disulfide bondi269 ↔ 279PROSITE-ProRule annotation
Disulfide bondi294 ↔ 303PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000020173

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027414

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 257EGF-likeInterPro annotationAdd BLAST32
Domaini265 – 304EGF-likeInterPro annotationAdd BLAST40
Domaini312 – 346EGF-likeInterPro annotationAdd BLAST35
Domaini352 – 443Ig-likeInterPro annotationAdd BLAST92
Domaini447 – 544Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini546 – 641Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini645 – 738Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini838 – 1117Protein kinaseInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00910000144091
HOGENOMiHOG000049232
HOVERGENiHBG007316
KOiK05120
OMAiFENFTYA
OrthoDBiEOG091G00RL
TreeFamiTF317568

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF00047 ig, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00060 FN3, 3 hits
SM00409 IG, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49265 SSF49265, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 3 hits
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

B5DFD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWWGSPFLL PILFLASHVG ASVDLTLLAN LRITEPQRFF LTCVSGEAGA
60 70 80 90 100
GRSSDVWGPP LLLEKDDRIV RTFPPGQPLH LTRNGSHQVT LRGFSKPSDL
110 120 130 140 150
VGVFSCVGGA GTRRTRVLYV HNSPGAHLFP DKVTHTVNKG DTAVLSARVH
160 170 180 190 200
KEKQTDVIWK NNGSYFHTLD WHEAHDGRFQ LQLQNVQPPS SGIYSATYLE
210 220 230 240 250
ASPLGSAFFR LIVRGCEAGR WGPGCVKDCP GCLHGGVCHD HDGECVCPPG
260 270 280 290 300
FTGTRCEQAC REGRFGQSCQ EQCPGTAGCR GLTFCLPDPY GCSCGSGWRG
310 320 330 340 350
SQCQEACAPG HFGADCRLQC QCQNGGTCDR FSGCVCPSGW HGVHCEKSDR
360 370 380 390 400
IPQILNVATE LEFNLGTMPR INCAAAGNPF PVRGSMELRK PDGTMLLSTK
410 420 430 440 450
AIVEPDRTTA EFEVPRLTLG DSGFWECRVS TSGGQDSRRF KVNVKVPPVP
460 470 480 490 500
LTAPRLLAKQ SRQLVVSPLV SFGGDGPISS VRLHYRPQDS MITWSAIVVD
510 520 530 540 550
PSENVTLMNL KPRTGYNVRV QLSRPGEGGE GAWGPSTLMT TDCPEPLLQP
560 570 580 590 600
WVESWNVEGP DRLRVSWSLP SVPLSGDGFL LRLWDGARGQ ERRENISSPQ
610 620 630 640 650
ARTALLTGLT PGTHYQLDVR LYHCTLLGPA SPSAHVHLPL SGPPAPRHLR
660 670 680 690 700
AQALSDSEIR LMWQHPEAPP GPISKYIVEI QVAGGSGDPQ WMDVDKPEET
710 720 730 740 750
STTVRGLNAS TRYLFRVRAS VQGLGDWSNT VEETTLGNGL QSASPVQESR
760 770 780 790 800
VAEDGLDQQL VLAVVGSVSA TCLTILAALL ALVCIRRSCL HRRHTFTYQS
810 820 830 840 850
GSGEETILQF SSGTLTLTRR PKPQPEPLSY PVLEWEDITF EDLIGEGNFG
860 870 880 890 900
QVIRAMIKKD GLKMNAAIKM LKEYASENDH RDFAGELEVL CKLGHHPNII
910 920 930 940 950
NLLGACENRG YLYIAIEYAP YGNLLDFLRK SRVLETDPAF AREHGTASTL
960 970 980 990 1000
SSRQLLRFAS DAANGMQYLS EKQFIHRDLA ARNVLVGENL ASKIADFGLS
1010 1020 1030 1040 1050
RGEEVYVKKT MGRLPVRWMA IESLNYSVYT TKSDVWSFGV LLWEIVSLGG
1060 1070 1080 1090 1100
TPYCGMTCAE LYEKLPQGYR MEQPRNCDDE VYELMRQCWR DRPYERPPFA
1110 1120 1130
QIALQLGRML EARKAYVNMS LFENFTYAGI DATAEEA
Length:1,137
Mass (Da):125,210
Last modified:October 14, 2008 - v1
Checksum:iB0CA77DA59261E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07049769 Genomic DNA No translation available.
AABR07049770 Genomic DNA No translation available.
AABR07049771 Genomic DNA No translation available.
BC169020 mRNA Translation: AAI69020.1
RefSeqiNP_445997.1, NM_053545.1
UniGeneiRn.13171

Genome annotation databases

EnsembliENSRNOT00000027414; ENSRNOP00000027414; ENSRNOG00000020173
GeneIDi89806
KEGGirno:89806

Similar proteinsi

Entry informationi

Entry nameiB5DFD6_RAT
AccessioniPrimary (citable) accession number: B5DFD6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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