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Protein
Submitted name:

Vasp protein

Gene

Vasp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Vasp proteinImported
Gene namesi
Name:VaspImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1311542 Vasp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projectionUniRule annotation, Cytoplasm, CytoskeletonUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiB5DEX4

PTM databases

iPTMnetiB5DEX4
PhosphoSitePlusiB5DEX4

Expressioni

Gene expression databases

GenevisibleiB5DEX4 RN

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114WH1InterPro annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili341 – 368Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the Ena/VASP family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4590 Eukaryota
ENOG41101TS LUCA
HOGENOMiHOG000013015
HOVERGENiHBG006655
KOiK06274
PhylomeDBiB5DEX4
TreeFamiTF321411

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR034367 VASP
IPR017354 VASP/EVL
IPR038023 VASP_sf
IPR014885 VASP_tetra
IPR000697 WH1/EVH1_dom
PANTHERiPTHR11202:SF12 PTHR11202:SF12, 1 hit
PfamiView protein in Pfam
PF08776 VASP_tetra, 1 hit
PF00568 WH1, 1 hit
PIRSFiPIRSF038010 Vasodilator_Phospo, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
SUPFAMiSSF118370 SSF118370, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

Sequencei

Sequence statusi: Complete.

B5DEX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNETVICSS RATVMLYDDS NKRWLPAGTG PQAFSRVQIY HNPTANSFRV
60 70 80 90 100
VGRKLQPDQQ VVINCAIIRG VKYNQATPIF HQWRDARQVW GLNFGSKEDA
110 120 130 140 150
AQFAIGMANA LEALEGGGPP PAPAPPAWST QNGPSPEELE QQKRQPEHLE
160 170 180 190 200
RRVSNAGGPP APPAGGPPPP PGPPPPPGPP PPPGLPPSGV SGAGHGTGVA
210 220 230 240 250
PPPAPPLPTA QGPSSGGSGA PGLAAAIAGA KLRKVSKEEA SGGPLAPKAE
260 270 280 290 300
NSRGTGGGLM EEMNAMLARR RKATQVGEKP PKDESASQEE SEARIPAQSE
310 320 330 340 350
PVRRPWEKNS TTLPRMKSSS SVTTSEAHPS VPSSSDDSDL ERVKQELVEE
360 370
VRKELQKMKE EIIEVFVQEL RKRGSP
Length:376
Mass (Da):39,724
Last modified:October 14, 2008 - v1
Checksum:i1C082BB7AE1C0DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168841 mRNA Translation: AAI68841.1
RefSeqiNP_001101945.2, NM_001108475.2
UniGeneiRn.98750

Genome annotation databases

GeneIDi361517
KEGGirno:361517
UCSCiRGD:1311542 rat

Similar proteinsi

Entry informationi

Entry nameiB5DEX4_RAT
AccessioniPrimary (citable) accession number: B5DEX4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health