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Protein

Probable Xaa-Pro aminopeptidase 3

Gene

Xpnpep3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi331Manganese 2By similarity1
Metal bindingi342Manganese 1By similarity1
Metal bindingi342Manganese 2By similarity1
Metal bindingi423Manganese 1By similarity1
Metal bindingi450Manganese 1By similarity1
Metal bindingi474Manganese 1By similarity1
Metal bindingi474Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Protein family/group databases

MEROPSiM24.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Xaa-Pro aminopeptidase 3 (EC:3.4.11.9)
Short name:
X-Pro aminopeptidase 3
Alternative name(s):
Aminopeptidase P3
Short name:
APP3
Gene namesi
Name:Xpnpep3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1589063. Xpnpep3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004012091 – 506Probable Xaa-Pro aminopeptidase 3Add BLAST506

Proteomic databases

PaxDbiB5DEQ3.
PeptideAtlasiB5DEQ3.
PRIDEiB5DEQ3.

PTM databases

iPTMnetiB5DEQ3.
PhosphoSitePlusiB5DEQ3.

Expressioni

Tissue specificityi

Expressed in the kidney, specifically in intercalated cells, but not in principal cells, of the distal convoluted tubule and cortical collecting duct (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061709.

Structurei

3D structure databases

ProteinModelPortaliB5DEQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Phylogenomic databases

eggNOGiKOG2414. Eukaryota.
COG0006. LUCA.
HOGENOMiHOG000008762.
HOVERGENiHBG057305.
InParanoidiB5DEQ3.
KOiK01262.
PhylomeDBiB5DEQ3.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR007865. Aminopep_P_N.
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000994. Pept_M24.
[Graphical view]
PfamiPF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SMARTiSM01011. AMP_N. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DEQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLLSTPRL VPVIARLRGL SGCMSCLQRR YSLQPVPVKE IPNRYLGQPS
60 70 80 90 100
PVTHPHLLRP GEVTPGLSQV EYALRRHKLM ALVHKEAQGH SGTDHTVVVL
110 120 130 140 150
SNPIHYMSND IPYTFHQDNS FLYLCGFQEP DSILVLQSCS GKQLPSHKAM
160 170 180 190 200
LFVPRRDPGR ELWDGPRSGT DGAIALTGVD DAYPLEEFQH LLPKLRAETN
210 220 230 240 250
MVWYDWMKPS HAQLHSDYMQ PLTEAKATSK NKVRSVQHLI QHLRLIKSPA
260 270 280 290 300
EIKRMQIAGK LTSEAFIETM FASKAPVDEA FLYAKFEFEC RARGADILAY
310 320 330 340 350
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN
360 370 380 390 400
GRFTAPQAEL YEAVLEIQKA CLTLCSPGTS LENIYSMMLT LMGQKLKDLG
410 420 430 440 450
IIKTSKESAF KAARKYCPHH VGHYLGMDVH DTPDMPRSLP LQPGMVITVE
460 470 480 490 500
PGIYIPEGDT DAPEKFRGLG VRIEDDVVVT QDSPLILSAD CPKEVNDIEQ

ICSRTS
Length:506
Mass (Da):56,455
Last modified:October 14, 2008 - v1
Checksum:i6B793744D67B09F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168759 mRNA. Translation: AAI68759.1.
RefSeqiNP_001124054.2. NM_001130582.2.
UniGeneiRn.224672.

Genome annotation databases

GeneIDi685823.
KEGGirno:685823.
UCSCiRGD:1589063. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168759 mRNA. Translation: AAI68759.1.
RefSeqiNP_001124054.2. NM_001130582.2.
UniGeneiRn.224672.

3D structure databases

ProteinModelPortaliB5DEQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061709.

Protein family/group databases

MEROPSiM24.026.

PTM databases

iPTMnetiB5DEQ3.
PhosphoSitePlusiB5DEQ3.

Proteomic databases

PaxDbiB5DEQ3.
PeptideAtlasiB5DEQ3.
PRIDEiB5DEQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi685823.
KEGGirno:685823.
UCSCiRGD:1589063. rat.

Organism-specific databases

CTDi63929.
RGDi1589063. Xpnpep3.

Phylogenomic databases

eggNOGiKOG2414. Eukaryota.
COG0006. LUCA.
HOGENOMiHOG000008762.
HOVERGENiHBG057305.
InParanoidiB5DEQ3.
KOiK01262.
PhylomeDBiB5DEQ3.

Miscellaneous databases

PROiB5DEQ3.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR007865. Aminopep_P_N.
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000994. Pept_M24.
[Graphical view]
PfamiPF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SMARTiSM01011. AMP_N. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXPP3_RAT
AccessioniPrimary (citable) accession number: B5DEQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.