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Protein

BTB/POZ domain-containing protein KCTD5

Gene

Kctd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD5
Gene namesi
Name:Kctd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304990. Kctd5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 234233BTB/POZ domain-containing protein KCTD5PRO_0000390463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB5DEL1.

Expressioni

Gene expression databases

GenevisibleiB5DEL1. RN.

Interactioni

Subunit structurei

Homopentamer (By similarity). Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007850.

Structurei

3D structure databases

ProteinModelPortaliB5DEL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 146103BTBAdd
BLAST

Domaini

The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118 (By similarity).By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiB5DEL1.
OMAiYGTNSEP.
OrthoDBiEOG7JDQZF.
PhylomeDBiB5DEL1.
TreeFamiTF313754.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5DEL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENHCELLP PAPSGLGAGL GGGLCRRCSA GIGALAQRPS GVSKWVRLNV
60 70 80 90 100
GGTYFLTTRQ TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG
110 120 130 140 150
PVLNYLRHGK LVINRDLAEE GVLEEAEFYN ITSLIKLVKD KIRERDSKTS
160 170 180 190 200
QMPVKHVYRV LQCQEEELTQ MVSTMSDGWK FEQLVSIGSS YNYGNEDQAE
210 220 230
FLCVVSKELH NTPYGTTSEP SEKAKILQER GSRM
Length:234
Mass (Da):26,164
Last modified:October 14, 2008 - v1
Checksum:i05CCF56632DE4F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473948 Genomic DNA. Translation: EDM03804.1.
BC168712 mRNA. Translation: AAI68712.1.
RefSeqiNP_001099238.1. NM_001105768.1.
UniGeneiRn.161259.

Genome annotation databases

EnsembliENSRNOT00000084991; ENSRNOP00000073503; ENSRNOG00000057186.
GeneIDi287109.
KEGGirno:287109.
UCSCiRGD:1304990. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473948 Genomic DNA. Translation: EDM03804.1.
BC168712 mRNA. Translation: AAI68712.1.
RefSeqiNP_001099238.1. NM_001105768.1.
UniGeneiRn.161259.

3D structure databases

ProteinModelPortaliB5DEL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007850.

Proteomic databases

PaxDbiB5DEL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084991; ENSRNOP00000073503; ENSRNOG00000057186.
GeneIDi287109.
KEGGirno:287109.
UCSCiRGD:1304990. rat.

Organism-specific databases

CTDi54442.
RGDi1304990. Kctd5.

Phylogenomic databases

eggNOGiKOG2715. Eukaryota.
ENOG410XT4J. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000231167.
HOVERGENiHBG053302.
InParanoidiB5DEL1.
OMAiYGTNSEP.
OrthoDBiEOG7JDQZF.
PhylomeDBiB5DEL1.
TreeFamiTF313754.

Miscellaneous databases

PROiB5DEL1.

Gene expression databases

GenevisibleiB5DEL1. RN.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCTD5_RAT
AccessioniPrimary (citable) accession number: B5DEL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.