B5DEK8 (VOPP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vesicular, overexpressed in cancer, prosurvival protein 1

Alternative name(s):
EGFR-coamplified and overexpressed protein
Short name=ECop

Gene names

Name:	Vopp1
Synonyms:	Ecop

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the VOPP1/ECOP family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasmic vesicle Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endosome Inferred from electronic annotation. Source: Compara integral to organelle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 172	150	Vesicular, overexpressed in cancer, prosurvival protein 1		PRO_0000417668
Regions
	Topological domain	23 – 60	38	Extracellular Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Topological domain	82 – 172	91	Cytoplasmic Potential
	Compositional bias	87 – 164	78	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	B5DEK8 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 21B3D8D7A9BA0774	FASTA	172	19,411
	10 20 30 40 50 60 MARPLGRVAA LLLGLLMECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL 70 80 90 100 110 120 WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPTFNVSY TRQPPNPAPG AQQMGPPYYT 130 140 150 160 170 DPGGPGMNPV GNTMAMAFQV QPNSPHGGTT YPPPPSYCNT PPPPYEQVVK DK

References

[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryonic brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC126722 Genomic DNA. No translation available. CH474011 Genomic DNA. Translation: EDL88042.1. BC168709 mRNA. Translation: AAI68709.1.
IPI	IPI00358221.
RefSeq	NP_001102100.1. NM_001108630.1.
UniGene	Rn.154707.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000008885; ENSRNOP00000008885; ENSRNOG00000006646.
GeneID	362374.
KEGG	rno:362374.
Organism-specific databases
CTD	81552.
RGD	1306494. Vopp1.
Phylogenomic databases
eggNOG	NOG79107.
GeneTree	ENSGT00390000015821.
HOGENOM	HOG000065719.
HOVERGEN	HBG104569.
OMA	MAFHVQP.
OrthoDB	EOG48GW4N.
Gene expression databases
ArrayExpress	B5DEK8.
Genevestigator	B5DEK8.
Family and domain databases
InterPro	IPR026229. VOPP1. [Graphical view]
PRINTS	PR02068. VOPPROTEIN1.
ProtoNet	Search...
Other
NextBio	679687.

Entry information

Entry name

VOPP1_RAT

Accession

Primary (citable) accession number: B5DEK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2012
Last sequence update:	October 14, 2008
Last modified:	March 6, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program