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Protein

Alpha-mannosidase

Gene

Man2b2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  • alpha-mannosidase activity Source: RGD
  • carbohydrate binding Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • mannose metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
Gene namesi
Name:Man2b2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1308840. Man2b2.

Subcellular locationi

GO - Cellular componenti

  • lysosome Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 1004983Alpha-mannosidaseSequence analysisPRO_5002829155Add
BLAST

Proteomic databases

PaxDbiB5DEJ3.
PRIDEiB5DEJ3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062052.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini356 – 43984Alpha-mann_midInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1959. Eukaryota.
ENOG410XQMZ. LUCA.
HOGENOMiHOG000113450.
HOVERGENiHBG052392.
KOiK12312.
PhylomeDBiB5DEJ3.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR013780. Glyco_hydro_b.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

B5DEJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLRWLPLL GQLLLLWPLA ARPASPIRAF VVPHSHMDVG WVYTVQESMR
60 70 80 90 100
AYAANVYTTV VEELVRGRQR RFIAVEQEFF RLWWDGVASE QQKQQVRQLL
110 120 130 140 150
DEGCLEFVLG GQVMHDEAVT HLDDQILQLT EGHGFLYETF GIRPQFSWHV
160 170 180 190 200
DPFGASATTP TLFSLAGFNA HLISRIDYDL KDAMQEAQGL QFVWHGSPSL
210 220 230 240 250
SEQQEIYTHV MDLYSYCTPS HIPFSNRSGF YWNGVAVFPE PPPDGVYPNM
260 270 280 290 300
SEPVTVDNIH LYAEALVANI KQRAAWFRTP HVLWPWGCDK QFFNASVQFD
310 320 330 340 350
NMDPLLEYIN NRSAQFGISV QYATLNDYFQ ALHDFNVTWD IRDHHDFLPY
360 370 380 390 400
SSEPQQAWTG FYTSRSTLKG LARQASALLY AGESMFTRYM WPHPRGTLDP
410 420 430 440 450
TWALQQLQQL RWAVSEVQHH DAITGTESPK VKNMYMEHLS MGMRGVHKLM
460 470 480 490 500
ASIALDRSPG SGTDTRPVGY SASVYNPLAW KITTIITLTV AFPSVSVTDE
510 520 530 540 550
LGRPVSAQIQ NSTKDPSAYD LLILTTIPGL SYRYYKVRRI LGDQAGTREL
560 570 580 590 600
VTPRANTLKF SRKLRNQTSQ EGKLLVPVMN DCYTLLFDQD TNMLHSIQDR
610 620 630 640 650
QSNRTVHMTQ EFLEYRANGD VKQGPISDNY LFASNDTAEP SWEAVGMEMV
660 670 680 690 700
VGTLATDVRQ YFYRNITDQG YIYSIHTRLA HVHPSLAGEL LCRRIEQQYQ
710 720 730 740 750
VGPLDLNREA ILRTSSDLNS QQVLYSDNNG YQMQRRPYKA FKSNPIPRNY
760 770 780 790 800
YPMVQSAFIE DDKSRLVLLA ERPHGVSSQE NGQVEVMLHR RLWNNLVWDL
810 820 830 840 850
NYNLTLNDTS VVHPVLWLLL GPKSTTTALR PRSGVALQHR PVVLLKELTD
860 870 880 890 900
EEETAIHRPH HPWPVTLPPS LHLQVLSLRG WQYSRNHAQH LKNLQRGHPE
910 920 930 940 950
KPQVNLQRVL LRLHHLYEAG EDPVLSRPAT VDLKIALRGL GSVVAVEERS
960 970 980 990 1000
LTGTWDVQTL QRWHWRTKIG QLKGHPTSPP RSPGGSIITV YPKEIRTFFI

YLQQ
Length:1,004
Mass (Da):114,896
Last modified:October 14, 2008 - v1
Checksum:i2FE55B964226DAF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168692 mRNA. Translation: AAI68692.1.
RefSeqiNP_001128443.1. NM_001134971.2.
UniGeneiRn.139036.

Genome annotation databases

GeneIDi360955.
KEGGirno:360955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168692 mRNA. Translation: AAI68692.1.
RefSeqiNP_001128443.1. NM_001134971.2.
UniGeneiRn.139036.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062052.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Proteomic databases

PaxDbiB5DEJ3.
PRIDEiB5DEJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360955.
KEGGirno:360955.

Organism-specific databases

CTDi23324.
RGDi1308840. Man2b2.

Phylogenomic databases

eggNOGiKOG1959. Eukaryota.
ENOG410XQMZ. LUCA.
HOGENOMiHOG000113450.
HOVERGENiHBG052392.
KOiK12312.
PhylomeDBiB5DEJ3.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
IPR013780. Glyco_hydro_b.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB5DEJ3_RAT
AccessioniPrimary (citable) accession number: B5DEJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.